Biological response of Schiff base metal complexes incorporating amino acids – a short review

Arunadevi, Alagarraj; Raman, Natarajan

doi:10.1080/00958972.2020.1824293

Cited by 58 publications

(21 citation statements)

References 37 publications

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“…Schiff bases derived from dipropylenetriamine and 2-thiophene-carboxaldehyde have been tested for their anti-inflammatory activity 51 . Schiff bases derived from 3-(4-(benzylideneamino) phenylimino) 4-fluoroindolin-2-one have been tested for their anti-inflammatory properties and found to possess significant activity comparable to diclofenac 52 .…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Medicinal Utility of Some Schiff Bases and their Complexes with First Transition Series Metals: A Review

Khan

Zehra²,

Alvi³

et al. 2021

Orient. J. Chem

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Schiff based ligands and their complexes have emerged as potential drug candidates. Owing to their excellent chelating tendency, they easily coordinate with transition metals which have vacant orbitals. Transition metal complexes have several advantages because of their better acceptability and low toxicity in biological systems. These metals also serve as micronutrients and as co-factors of various metallo-enzymes which justifies the need of their designing and synthesis. Many modifications have been suggested in the ligand moiety for the purpose of activity enhancement and some of them have been described in the present review. These modifications have enhanced better potency against a number of diseases and resulting in low toxicity and better solubility in vivo. The transition metal complexes with Schiff based complexes have exhibited an array of activities including anticancer, antioxidant and antimicrobial. Their analytical applications have also been reported. The present review summarizes some of the recent advances in the field of synthesis and designing of new Schiff based complexes particularly with first transition series metals and their medicinal applications.

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Medicinal Utility of Some Schiff Bases and their Complexes with First Transition Series Metals: A Review

Khan

Zehra²,

Alvi³

et al. 2021

Orient. J. Chem

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“…[6,7] In the FT-IR characterization studies of the Schiff bases, a strong absorption band is shown around 1608 cm À 1 , which corresponds to the azomethine group, while in its metal complexes the band changes to higher values. In 1 H and 13 C NMR spectroscopy, the chemical shifts of the azomethine group are at 8 ppm and 165 ppm, respectively. In UV-Vis spectra, their complexes reveal a strong intra-ligand charge transfer transition absorption at 400 nm and a broadband d-d transition at 500 nm.…”

Section: Introductionmentioning

confidence: 99%

Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity

et al. 2022

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Although it is known that the first case of cancer was recorded in ancient Egypt around 1600 BC, it was not until 1917 during the First World War and the development of mustard gas that chemotherapy against cancer became relevant; however, its properties were not recognised until 1946 to later be used in patients. In this sense, the use of metallopharmaceuticals in cancer therapy was extensively explored until the 1960s with the discovery of cisplatin and its anticancer activity. From that date to the present, the search for more effective, more selective metallodrugs with fewer side effects has been an area of continuous exploration. Efforts have led to considering a wide variety of metals from the periodic table, mainly from the d-block, as well as a wide variety of organic ligands, preferably with proven biological activity. In this sense, various research groups have found an ideal binder in Schiff bases, since their raw materials are easily accessible, their synthesis conditions are friendly and their denticity can be manipulated. Therefore, in this review, we have explored the anticancer and antitumor activity reported in the literature for coordination complexes of d-block metals coordinated with tridentate Schiff bases (O N O and O N N) derived from salicylaldehyde. For this work, we have used the main scientific databases CCDC® and SciFinder®.

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“…Schiff bases were discovered by Hugo Schiff, and their metal complex derivatives were largely synthesized, for example, incorporating amino acids [1]. Their fields of application are varied and concern, for example, environmental sensors [2], catalysis [3,4], and anticancer [5,6] or antioxidant agents, but they also serve as antimicrobial agents, particularly against bacterial and fungal pathogens, showing that, compared to Co(II), Ni(II) or Zn(II), Cu(II) complexes show lower MIC values, revealing that these complexes present a better growth inhibitory activity [7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Identification and Antibacterial Activities of Amino Acid Schiff Base Cu(II) Complexes with Chlorinated Aromatic Moieties

Otani

Fayeulle

Nakane

et al. 2022

Applied Microbiology

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Amino acid Schiff base Cu(II) complexes were synthesized under microwave irradiation using methanol as a solvent, to maximize the best conditions to obtain the attained compounds, containing aromatics possessing no, one or two chlorine atoms. The compounds’ antibacterial activities were tested against Gram-positive and Gram-negative bacteria, and the most active were tested for their antioxidant activities, and as E. coli, in particular, was found to be sensitive to these compounds, their interaction with this bacterium was investigated. It was found that, depending on the amino acid used for the formation of the Schiff base ligand, its LogPo/w mono-chlorinated or bis-chlorinated compounds are the most efficient against the tested bacteria.

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Biological response of Schiff base metal complexes incorporating amino acids – a short review

Cited by 58 publications

References 37 publications

Medicinal Utility of Some Schiff Bases and their Complexes with First Transition Series Metals: A Review

Medicinal Utility of Some Schiff Bases and their Complexes with First Transition Series Metals: A Review

Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity

Synthesis, Identification and Antibacterial Activities of Amino Acid Schiff Base Cu(II) Complexes with Chlorinated Aromatic Moieties

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