Biological Responses of Young Rats Fed Diets Containing Genistin and Genistein

Magee, A. C.

doi:10.1093/jn/80.2.151

Cited by 20 publications

(8 citation statements)

References 20 publications

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“…However, from studies on other animals it is known that trypsin inhibitors from raw soybeans increase the cell proliferation in pancreatic tissue of chicken and rats (Chernick, Lepkovsky & Chaikkoff 1948; Yanatori & Fujita 1976). Phytoestrogens are reported to stimulate growth of different target organs (Magee 1963). Lectins, another group of anti‐nutritional factors in soybeans, are reported to interact with the epithelial surface of the intestine causing hyperplasia of the basal cells of the intestinal folds (Grant, Watt, Stewart & Pusztai 1987).…”

Section: Discussionmentioning

confidence: 99%

An examination of the intestinal tract of Atlantic salmon, Salmo salar L., parr fed different varieties of soy and maize

Sanden¹,

Berntssen²,

Krogdahl

et al. 2005

Journal of Fish Diseases

106

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This study was conducted to investigate the long-term effects of feeding plant products from both traditional breeding and from biotechnology on intestinal somatic indices, histology and cell proliferation in first-feeding Atlantic salmon, Salmo salar L. (initial weight 0.21 +/- 0.02 g). A standard fishmeal diet (standard fishmeal) was formulated to contain fishmeal as the sole protein source and suprex maize as the main starch source. Six experimental diets were then developed: two in which some of the fishmeal was replaced with commercially available, genetically modified Roundup Ready full-fat soybean meal (GM-soy) or commercially available, non-GM full-fat soybean meal (nGM-soy) at a level of 12.5% of the total diet, and four diets in which the suprex maize was replaced with two lines of GM-maize (Dekalb 1; D1 and Pioneer 1; P1), both products of event MON810, and their half-sibling non-GM counterparts (Dekalb 2; D2 and Pioneer 2; P2), at a level of 12.1% of total diet. Each diet was fed to fish in triplicate tanks and the experiment lasted for 8 months, during which the fish reached a final weight of 101-116 g. There was no significant effect of diet on the intestinal indices, nor were histological changes observed in the pyloric caeca or mid intestine. In the distal intestine, one of nine sampled fish fed nGM-soy showed moderate changes, two of nine sampled fish fed GM-soy showed changes, one with moderate and one with severe changes, and two of nine fish fed nGM-maize D2 had moderate changes. Using a monoclonal antibody against proliferating cell nuclear antigen (PCNA), cell proliferative responses to the experimental diets were assessed. In fish fed both soy diets, a significantly higher (P < 0.05) cell proliferation response was observed in the distal intestine concomitant with an increased localization of PCNA positive cells along the whole distal intestinal folds. The PCNA response among the nGM-soy group was significantly higher compared with all the other diet groups. In contrast, for fish exposed to dietary maize (type D) compared with fish fed the standard fishmeal, the soy-diets (GM-soy and nGM-soy) and maize (type P), a significantly lower (P < 0.05) cell proliferation response was observed in the distal intestine. Results indicated that the GM plant products investigated in this study, at about 12% inclusion level, were as safe as commercially available non-GM products, at least in terms of their effect on indices and histological parameters of the Atlantic salmon intestinal tract.

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Section: Discussionmentioning

confidence: 99%

An examination of the intestinal tract of Atlantic salmon, Salmo salar L., parr fed different varieties of soy and maize

Sanden¹,

Berntssen²,

Krogdahl

et al. 2005

Journal of Fish Diseases

106

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“…In a test of 16 vegetables, 13 contained coumestrol, with the highest levels in sprouted alfalfa and soybean seeds (Knuckels et al, 1976). High levels of estrogenic substances in forage crops fed to cattle, sheep, hogs, and mice result in severe biological effects, including increased teat length, gestation time, and uterine weight, as well as prolapsed vagina, cervix, and rectum (Bradbury and White, 1954;Bickoff et al, 1960Bickoff et al, ,1962Magee, 1963;Braden et al, 1964;Cox and Braden, 1974;Trenkle and Burroughs, 1978). Beneficial effects of such substances have also been reported and include increased rate of growth and milk production (Cheng et al, 1953;Bradbury and White, 1954;Livingston et al, 1961;Bickoff et al, 1962;Oldfield et al, 1966;Trenkle and Burroughs, 1978).…”

Section: Communicationsmentioning

confidence: 99%

Analysis of coumestrol, a plant estrogen, in animal feeds by high-performance liquid chromatography

Gl¹

1980

J. Agric. Food Chem.

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“…No significant adverse effects were noted in rats fed 0.1% genistein (equivalent to 0.16% genistin) in a 19% casein diet for 4 weeks. To obtain an effect from soybean meal equivalent to that observed in the experiments of Magee (184), soybean meal would have to be the sole constituent of the diet. The isoflavone content of soy protein isolates is extremely low.…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Biological and physiological factors in soybeans

Rackis

1974

J Americ Oil Chem Soc

203

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There are limitations to which one is justified in drawing broad generalizations concerning the diverse biological and physiological effects of soy protein products. Nevertheless, there appear to be two distinct situations: (A.) Proper heat treatment exerts TI activity b 66-233 c Hemagglutinating activity 60-426 d Protein efficiency ratio 0.88-1.60 e Protein efficiency ratio 0.74-1.74 f aSee ref. 9. bTI = trypsin inhibitor. CExpressed as trypsin units inhibited/rag protein.162A

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Biological Responses of Young Rats Fed Diets Containing Genistin and Genistein

Cited by 20 publications

References 20 publications

An examination of the intestinal tract of Atlantic salmon, Salmo salar L., parr fed different varieties of soy and maize

An examination of the intestinal tract of Atlantic salmon, Salmo salar L., parr fed different varieties of soy and maize

Analysis of coumestrol, a plant estrogen, in animal feeds by high-performance liquid chromatography

Biological and physiological factors in soybeans

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