Biological responses to terahertz radiation with different power density in primary hippocampal neurons

Zhao, Li; Yi, Ruhan; Sun, Liguang; Chi, Yunliang; Tan, Shengzhi; Dong, Ji; Wang, Hui; Zhang, Jing; Wang, Haoyu; Xu, Xinping; Yao, Binwei; Wang, Bo; Peng, Ruiyun

doi:10.1371/journal.pone.0267064

Cited by 9 publications

(5 citation statements)

References 30 publications

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“…The relationship between temperature and microtubule assembly was analyzed, and it was determined that this phenomenon is associated with the increased temperature of the neuron [ 71 , 72 ]. Additionally, higher radiation powers (0.12 THz, 10 mW; 0.157 THz, 50 mW) have been shown to induce neuronal apoptosis, along with mitochondrial damage and increased lysosomes [ 73 ].…”

Section: The Impact Of Terahertz Radiation On Neuronal Morphology And...mentioning

confidence: 99%

“…The above studies have shown that high-power terahertz radiation disrupts actin structural disassembly and causes neuronal death, mitochondrial damage, and increased lysosomes and that there is a significant increase in neuronal temperature [ 71 , 72 , 73 ]. It is evident that high-power terahertz radiation causes thermal effects on neurons and can negatively affect them [ 74 , 75 ].…”

Section: The Impact Of Terahertz Radiation On Neuronal Morphology And...mentioning

confidence: 99%

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Terahertz Radiation Modulates Neuronal Morphology and Dynamics Properties

Ma,

Ding,

Zhou

et al. 2024

Brain Sciences

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Terahertz radiation falls within the spectrum of hydrogen bonding, molecular rotation, and vibration, as well as van der Waals forces, indicating that many biological macromolecules exhibit a strong absorption and resonance in this frequency band. Research has shown that the terahertz radiation of specific frequencies and energies can mediate changes in cellular morphology and function by exciting nonlinear resonance effects in proteins. However, current studies have mainly focused on the cellular level and lack systematic studies on multiple levels. Moreover, the mechanism and law of interaction between terahertz radiation and neurons are still unclear. Therefore, this paper analyzes the mechanisms by which terahertz radiation modulates the nervous system, and it analyzes and discusses the methods by which terahertz radiation modulates neurons. In addition, this paper reviews the laws of terahertz radiation’s influence on neuronal morphology and kinetic properties and discusses them in detail in terms of terahertz radiation frequency, energy, and time. In the future, the safety of the terahertz radiation system should be considered first to construct the safety criterion of terahertz modulation, and the spatial resolution of the terahertz radiation system should be improved. In addition, the systematic improvement of the laws and mechanisms of terahertz modulation of the nervous system on multiple levels is the key to applying terahertz waves to neuroscience. This paper can provide a platform for researchers to understand the mechanism of the terahertz–nervous system interaction, its current status, and future research directions.

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Section: The Impact Of Terahertz Radiation On Neuronal Morphology And...mentioning

confidence: 99%

Section: The Impact Of Terahertz Radiation On Neuronal Morphology And...mentioning

confidence: 99%

Terahertz Radiation Modulates Neuronal Morphology and Dynamics Properties

Ma,

Ding,

Zhou

et al. 2024

Brain Sciences

View full text Add to dashboard Cite

show abstract

“…Nervous tissue cells in particular have been found to release their intracellular proteolytic enzymes and suffer membrane protein changes under THz. No great morphological changes such as axon number or size have been recorded [56,57]. Various types of neurons also show different reactions to T-rays as seen by their marked changes in neurotransmitter production [58].…”

Section: Curative and Toxic Propertiesmentioning

confidence: 99%

Introduction to the Biological Effects of Terahertz Radiation

Bucur-Portase¹

2023

Trends in Terahertz Technology

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Terahertz (THz) radiation has been noted to affect biological organisms to a unique degree with various effects ranging from modifications brought to protein activity to epigenetic changes that lead to altered metabolism or reproduction. These effects are classified into thermal and non-thermal, with the former being caused by THz’s capacity to induce localised thermal changes while the latter involves more complex interactions with cells’ macromolecules which are poorly understood. Terahertz’s ability to enhance actin polymerisation and alter gene expression leads to a number of possible applications in agriculture, as it has been observed that certain plant species have higher growth speeds post-exposure, and medicine, with cancer’s rapid division being possibly slowed down.

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“… 14 The 0.12 THz wave with a power of 10 mW or the 0.157 THz wave with a power of 50 mW could also induce significant apoptosis in primary hippocampal neurons. 15 Hence, the alleged biosafety of THz does not necessarily mean there is no negative impact at all. More research is needed to understand the potential benefits or drawbacks associated with the exposure to THz waves.…”

Section: Introductionmentioning

confidence: 99%

0.263 terahertz irradiation induced genes expression changes in Caenorhabditis elegans

Shang,

Gao,

Zhang

et al. 2024

iScience

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Biological responses to terahertz radiation with different power density in primary hippocampal neurons

Cited by 9 publications

References 30 publications

Terahertz Radiation Modulates Neuronal Morphology and Dynamics Properties

Terahertz Radiation Modulates Neuronal Morphology and Dynamics Properties

Introduction to the Biological Effects of Terahertz Radiation

0.263 terahertz irradiation induced genes expression changes in Caenorhabditis elegans

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