1982
DOI: 10.1002/1520-6866(1990)2:1<19::aid-tcm1770020104>3.0.co;2-3
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Biological responsiveness to the phorbol esters and specific binding of [3H]phorbol 12,13-dibutyrate in the nematodeCaenorhabditis elegans, a manipulable genetic system

Abstract: Because of its suitability for genetic studies, the nematode Caenorhabditis elegans was examined for its responsiveness to the phorbol esters. Phorbol 12-myristate 13-acetate had three effects. It inhibited the increase in animal size during growth; it decreased the yield of progeny; and it caused uncoordinated movement of the adult. The effects on nematode size, progeny yield, and movement were quantitated. Concentrations of phorbol 12-myristate 13-acetate yielding half-maximal responses were 440, 460, and 17… Show more

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Cited by 16 publications
(3 citation statements)
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“…The structure activity requirements for binding are consistent with the receptor mediating a number of the biological responses to the phorbol esters. Binding studies indicate that phorbol ester receptors are found in all tissues and that they are highly conserved over evolution (14,15). The highest level of specific binding, 30 (17).…”
mentioning
confidence: 99%
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“…The structure activity requirements for binding are consistent with the receptor mediating a number of the biological responses to the phorbol esters. Binding studies indicate that phorbol ester receptors are found in all tissues and that they are highly conserved over evolution (14,15). The highest level of specific binding, 30 (17).…”
mentioning
confidence: 99%
“…[3H]PBt2 (specific activity, [13][14][15][16][17] Ci/mmol; 1 Ci = 3.7 x 1010 Bq) and [20-3H] (Fig. 1).…”
mentioning
confidence: 99%
“…This laboratory has demonstrated specific, saturable binding of the phorbol esters to tissue particulate preparations and intact cells from a variety of organisms (5)(6)(7)(8)(9)(10). The structure-activity requirements for binding are consistent with the receptors mediating the biological responses to the phorbol esters.…”
mentioning
confidence: 99%