Biological role of mannose binding lectin: From newborns to centenarians

Scorza, Manuela; Liguori, Renato; Elce, Ausilia; Salvatore, Francesco; Castaldo, Giuseppe

doi:10.1016/j.cca.2015.03.007

Cited by 29 publications

(28 citation statements)

References 41 publications

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“…Many studies showed that a low or high serum MBL level is involved in several immune mediated diseases (e.g., RA, Crohn’s disease, Sjögren disease and diabetic retinopathy 22–24 ). Immune defense function of MBL is associated with its serum level and oligomeric type 23 . Five SNPs of the MBL2 gene, including three structure variants, codon 52 (rs5030737), 54 (rs1800450), 57 (rs1800451) and two promoter variants, −550 (rs11003125) and −221(rs7096206) are thought to be responsible for reducing MBL2 serum levels and influencing the formation as well as the stability of oligomeric MBL2 25–27 .…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms of C-type lectin receptors in Behcet’s disease in a Chinese Han population

Yang

Tan

Deng

et al. 2017

Sci Rep

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C-type lectin receptors (CLRs) have been demonstrated to be involved in several autoimmune diseases. The role of CLRs in Behcet’s disease (BD) is unknown and thus was the purpose of this study. A two-stage association study was carried out and a total of 766 BD patients and 1674 healthy controls were recruited. Genotyping of 14 SNPs of 13 genes in CLRs was carried out by iPLEX Gold genotyping or polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The expression of mannose binding lectin 2 (MBL2) and killer cell lectin like receptor C4 (KLRC4) was measured by Real-time PCR. Significantly increased frequencies of the A allele as well as AA genotype of rs1800450 in MBL2 (Pc = 2.50 × 10−6, OR = 1.494; Pc = 2.24 × 10−6,OR = 2.899; respectively) and TT genotype of rs2617170 in KLRC4 (Pc = 2.53 × 10−6, OR = 1.695) and decreased frequencies of GG genotype of rs1800450 (Pc = 1.56 × 10−3, OR = 0.689) and C allele as well as CC genotype of rs2617170 (Pc = 2.05 × 10−9,OR = 0.664; Pc = 1.20 × 10−5, OR = 0.585; respectively) were observed in BD. Two variants, p.Gly54Asp (rs1800450) and p.Asn104Ser (rs2617170) affect MBL2 and KLRC4 protein stability and expression. Our study demonstrates that the MBL2/rs1800450 and KLRC4/rs2617170 are susceptibility factors for BD in a Chinese Han population.

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Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms of C-type lectin receptors in Behcet’s disease in a Chinese Han population

Yang

Tan

Deng

et al. 2017

Sci Rep

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“…99 Low MBL levels appear to predispose persons to bacterial infectious diseases, particularly in neonatal age and early childhood. 93 observed. 101 These results suggested that MBL may contribute to the first-line host defense against SARS-CoV and that MBL deficiency is a susceptibility factor for the acquisition of SARS.…”

Section: Mbl Is Polymorphic and Low Levels Predispose To Sars-cov mentioning

confidence: 94%

The first, holistic immunological model of COVID‐19: Implications for prevention, diagnosis, and public health measures

Matricardi

Negro²,

Nisini

2020

Pediatric Allergy Immunology

187

210

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“…A genetic predisposition to maintain a vaginal microbiota dominated by BV‐associated bacteria has been investigated in a number of studies. Mannose‐binding lectin (MBL) is an antimicrobial protein that binds to carbohydrate antigens on bacterial surfaces and activates the complement system, resulting in the lysis or opsonisation of microorganisms . A link between a polymorphism in the MBL2 gene and recurrent BV in Brazilian women has been noted .…”

Section: Vaginal Epitheliummentioning

confidence: 99%

“…Mannose-binding lectin (MBL) is an antimicrobial protein that binds to carbohydrate antigens on bacterial surfaces and activates the complement system, resulting in the lysis or opsonisation of microorganisms. 81 A link between a polymorphism in the MBL2 gene and recurrent BV in Brazilian women has been noted. 82 A second study that evaluated the MBL polymorphism-BV connection in Italian women with recurrent BV failed to confirm this finding.…”

Section: Genetic Variationmentioning

confidence: 99%

Bacterial vaginosis: a critical analysis of current knowledge

Nasioudis

Linhares

Ledger

et al. 2016

BJOG

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Bacterial vaginosis (BV), the change from a Lactobacillusdominant vaginal microbiota to an anaerobic and facultative bacterial dominance, is associated with pathological sequelae. In many BV-positive women their microbiota is in fact normal and unrelated to pathology. Whether or not the dominance of BVassociated bacteria persists depends upon interactions between host and bacterial factors. Inconsistencies in diagnosis and erroneous associations with pathology may be due to a failure to differentiate between sub-populations of women. It is only in those women with a BV diagnosis in which the identified bacteria are atypical and persist that BV may be a clinical problem requiring intervention.Tweetable abstract Improved diagnosis of bacterial vaginosis is needed to accurately determine its role in pathology.

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Biological role of mannose binding lectin: From newborns to centenarians

Cited by 29 publications

References 41 publications

Genetic polymorphisms of C-type lectin receptors in Behcet’s disease in a Chinese Han population

Genetic polymorphisms of C-type lectin receptors in Behcet’s disease in a Chinese Han population

The first, holistic immunological model of COVID‐19: Implications for prevention, diagnosis, and public health measures

Bacterial vaginosis: a critical analysis of current knowledge

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