2024
DOI: 10.1159/000535560
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Biological Roles of 5-Oxo-6,8,11,14-Eicosatetraenoic Acid and the OXE Receptor in Allergic Diseases: Collegium Internationale Allergologicum Update 2024

Lin Lin,
Fei Dai,
Jinjin Wei
et al.

Abstract: <b><i>Background:</i></b> 5-Oxo-6,8,11,14-eicosatetraenoic acid (5-Oxo-ETE) is a metabolite of arachidonic acid shown to promote biological activities in different cell types. <b><i>Summary:</i></b> 5-Oxo-ETE is synthesized from the 5-lipoxygenase product 5S-HETE (5S-hydroxy-6,8,11,14-eicosatetraenoic acid) in the presence of the nicotinamide adenine dinucleotide phosphate (NADP)<sup>+</sup>-dependent enzyme 5-hydroxyeicosanoid dehydrogenase (5-HEDH).… Show more

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