Biological Scaffolds for Congenital Heart Disease

Harris, Amy G.; Salih, Tasneem; Ghorbel, Mohamed; Caputo, Massimo; Biglino, Giovanni; Carrabba, Michele

doi:10.3390/bioengineering10010057

Cited by 7 publications

(3 citation statements)

References 173 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ETR is another very attractive concept that relies on the fact that bioabsorbable material (a polymer as scaffold) may be replaced by own body tissue with all advantages of avoiding foreign body material. ETR combines three scientific disciplines: supramolecular chemistry, electrospinning, and regenerative medicine (41)(42)(43)(44)(45)(46)(47)(48)(49)(50). Nowadays, different tunable supramolecular polymers are available and they are characterized by different degrees of mechanical strength and rates of bioabsorption.…”

Section: The Future Polymer Scaffolds With the Potential For Endogeno...mentioning

confidence: 99%

Past, present, and future options for right ventricular outflow tract reconstruction

Carrel

2023

Front. Surg.

View full text Add to dashboard Cite

The pulmonary valve is the most frequently replaced cardiac valve in congenital heart diseases. Whether the valve alone or part of the right ventricular outflow tract have to be repaired or replaced depends on the specific pathological anatomy of the malformation. Once the decision to replace the pulmonary valve has been made, two options are available: the isolated transcatheter pulmonary valve replacement and the surgical implantation of a prosthetic valve either isolated or in combination with a procedure on the right ventricular outflow tract. In this paper, we will focus on the different past and present surgical options and present a new concept called “endogenous tissue restoration,” a promising alternative to the hitherto existing implants. From a general point of view, neither the transcatheter nor the surgical valvular implants are magic bullets in the arsenal for the management of valvular diseases. Smaller valves have to be frequently replaced because of outgrowth of the patients, larger tissue valves may present late structural valve deterioration, while xenograft and homograft conduits may calcify and therefore become narrowed within unpredictable incidence and interval following implantation. Based on long-term research efforts combining the knowledge of supramolecular chemistry, electrospinning, and regenerative medicine, endogenous tissue restoration has emerged most recently as a promising option to create long-term functioning implants. This technology is appealing because following resorption of the polymer scaffold and timely replacement through autologous tissue, no foreign material remain at all in the cardiovascular system. Proof-of-concept studies as well as small first-in-man series have been completed and have demonstrated favorable anatomic and hemodynamic results, comparable to currently available implants in the short term. Based on the initial experience, important modifications to improve the pulmonary valve function have been initiated.

show abstract

Section: The Future Polymer Scaffolds With the Potential For Endogeno...mentioning

confidence: 99%

Past, present, and future options for right ventricular outflow tract reconstruction

Carrel

2023

Front. Surg.

View full text Add to dashboard Cite

show abstract

Section: The Futurementioning

confidence: 99%

Emerging opportunities in congenital cardiac surgery

2023

Frontiers Research Topics

View full text Add to dashboard Cite

Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

show abstract

“…Adult stem cells and pluripotent stem cells are typically administered via intravascular injections, injections into the pericardium, or infusion of cardiac patches [81]. Moreover, these cells can be employed to repopulate synthetic and natural scaffolds, allowing for various recellularization methods ranging from simple manual cell seeding to sophisticated controllable systems [82,83].…”

Section: Stem Cell Therapymentioning

confidence: 99%

The Long and Winding Road to Cardiac Regeneration

Sacco,

Castaldo,

Di Meglio

et al. 2023

Applied Sciences

View full text Add to dashboard Cite

Cardiac regeneration is a critical endeavor in the treatment of heart diseases, aimed at repairing and enhancing the structure and function of damaged myocardium. This review offers a comprehensive overview of current advancements and strategies in cardiac regeneration, with a specific focus on regenerative medicine and tissue engineering-based approaches. Stem cell-based therapies, which involve the utilization of adult stem cells and pluripotent stem cells hold immense potential for replenishing lost cardiomyocytes and facilitating cardiac tissue repair and regeneration. Tissue engineering also plays a prominent role employing synthetic or natural biomaterials, engineering cardiac patches and grafts with suitable properties, and fabricating upscale bioreactors to create functional constructs for cardiac recovery. These constructs can be transplanted into the heart to provide mechanical support and facilitate tissue healing. Additionally, the production of organoids and chips that accurately replicate the structure and function of the whole organ is an area of extensive research. Despite significant progress, several challenges persist in the field of cardiac regeneration. These include enhancing cell survival and engraftment, achieving proper vascularization, and ensuring the long-term functionality of engineered constructs. Overcoming these obstacles and offering effective therapies to restore cardiac function could improve the quality of life for individuals with heart diseases.

show abstract

Biological Scaffolds for Congenital Heart Disease

Cited by 7 publications

References 173 publications

Past, present, and future options for right ventricular outflow tract reconstruction

Past, present, and future options for right ventricular outflow tract reconstruction

Emerging opportunities in congenital cardiac surgery

The Long and Winding Road to Cardiac Regeneration

Contact Info

Product

Resources

About