Biological screening of Amaranthus retroflexus L. (Amaranthaceae)

Amoli, J Salar; Sadighara, Parisa; Barin, Abbas; Yazdani, Amirnaser; Satari, Saeed

doi:10.1590/s0102-695x2009000400019

Cited by 13 publications

(5 citation statements)

References 16 publications

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“…Antiproliferative activity of SF-1.5v was determined as previously described by Amoli et al [ 24 ]. Briefly, HeLa cells were grown in 75 cm 3 flasks in DMEM medium plus 10% FCS.…”

Section: Methodsmentioning

confidence: 99%

Heterofucan from Sargassum filipendula Induces Apoptosis in HeLa Cells

et al. 2011

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Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated l-fucose. Heterofucan SF-1.5v was extracted from the brown seaweed Sargassum filipendula by proteolytic digestion followed by sequential acetone precipitation. This fucan showed antiproliferative activity on Hela cells and induced apoptosis. However, SF-1.5v was not able to activate caspases. Moreover, SF-1.5v induced glycogen synthase kinase (GSK) activation, but this protein is not involved in the heterofucan SF-1.5v induced apoptosis mechanism. In addition, ERK, p38, p53, pAKT and NFκB were not affected by the presence of SF-1.5v. We determined that SF-1.5v induces apoptosis in HeLa mainly by mitochondrial release of apoptosis-inducing factor (AIF) into cytosol. In addition, SF-1.5v decreases the expression of anti-apoptotic protein Bcl-2 and increased expression of apoptogenic protein Bax. These results are significant in that they provide a mechanistic framework for further exploring the use of SF-1.5v as a novel chemotherapeutics against human cervical cancer.

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“…Antiproliferative activity of SF-1.5v was determined as previously described by Amoli et al [ 24 ]. Briefly, HeLa cells were grown in 75 cm 3 flasks in DMEM medium plus 10% FCS.…”

Section: Methodsmentioning

confidence: 99%

Heterofucan from Sargassum filipendula Induces Apoptosis in HeLa Cells

et al. 2011

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“…Plants are unique in their ability to produce extraordinary effects 25 .The hogweed plant has therapeutic and nutritional properties. In Europe, it is used to treat diarrhea.…”

Section: Discussionmentioning

confidence: 99%

The effect of flavorings on PAHs level in the roasted sunflower seeds

Shavali-gilani,

Yazdanfar,

Jahed-khaniki

et al. 2023

Sci Rep

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The amount of polycyclic aromatic hydrocarbons (PAHs) can be reduced by food additives. In this study, the impact of various flavors was investigated on the formation of PAHs in roasted sunflower seeds. PAHs was measured in the shell and kernel of sunflower with the flavors of lemon, golpar (hogweed), salt, ketchup and raw sunflower. Measuring the amount of PAHs was analyzed by Gas chromatography–mass spectrometry (GC–MS). PAHs with low molecular weight were detected. The total of PAHs of sunflower seeds were in the range of 0.4–3.2 mg kg−1. The lowest amount was related to the hogweed kernel, and the highest amount was related to the lemon. High molecular weight PAHs were not detected because the temperature did not rise above 100 °C during roasting. Some flavors, such as hogweed can reduce the amount of PAHs because of their antioxidant properties. On the contrary, the PAHs level with lemon juice was higher than other flavors.

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“…The toxic compound that causes tubular nephrosis is, to date, unknown, although extracts of A . retroflexus have been shown in vitro to be toxic to bovine renal cells, suggesting a specific renal toxicity . Phenolic compounds similar to those found to cause tubular necrosis in oak species have been identified in the leaves of Amaranthus spp .…”

Section: Discussionmentioning

confidence: 99%