2024
DOI: 10.1182/bloodadvances.2023011425
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Biological signatures of the International Prognostic Index in diffuse large B-cell lymphoma

Yue Wang,
Qing Shi,
Zi-Yang Shi
et al.

Abstract: Diffuse large B-cell lymphoma (DLBCL) is a highly aggressive subtype of lymphoma with clinical and biological heterogeneity. The International Prognostic Index (IPI) shows great prognostic capability in the era of rituximab, but the biological signatures of IPI remains to be discovered. In this study, we analyzed the clinical data in a large cohort of 2592 newly diagnosed patients with DLBCL. Among them, 1233 underwent DNA sequencing for oncogenic mutations, and 487 patients underwent RNA sequencing for lympho… Show more

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