Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic cells specifically lyse allogeneic target cells.

Finberg, Robert W.; Burakoff, Steven J.; Cantor, Harvey; Benacerraf, Baruj

doi:10.1073/pnas.75.10.5145

Cited by 137 publications

(60 citation statements)

References 14 publications

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“…Generation of SV-specific CTL with cross-reactive activity on allogeneic target cells has been described [38,39]. We found even generation of alloreactive CTL without cross-reactive properties indicating polyclonal T cell activation by SV (U.…”

Section: Discussionmentioning

confidence: 52%

Generation of virus‐specific cytotoxic T cells in vitro I. Induction conditions of primary and secondary Sendai virus‐specific cytotoxic T cells

Koszinowski

Simon

1979

Eur J Immunol

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Heidelberg H-Zrestricted cytotoxic T cells specific for Sendai virus were generated in vitro in a primary response from normal mouse lymphocytes cultured in the presence of infective as well as inactivated Sendai virus. Antigen-presenting cells of different origin, including T cells, were found to be effective stimulators. Antibodies to Sendai virus were shown to inhibit the activation of specific precursor killer cells when added to cultures before, but not after, the addition of viral antigen. Data obtained by Lyt phenotyping, revealed that precursor killer cells specific for Sendai virus reside in the Lyt-2,3+ T cell population and that Lyt-1,2,3+ T cells are not required for the generation of cytotoxic lymphocytes. Different activation kinetics were demonstrated for primary and secondary antiviral cytotoxic responses, and the analysis of the proliferation and stimulation requirements suggests qualitative differences.

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Section: Discussionmentioning

confidence: 52%

Generation of virus‐specific cytotoxic T cells in vitro I. Induction conditions of primary and secondary Sendai virus‐specific cytotoxic T cells

Koszinowski

Simon

1979

Eur J Immunol

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“…1). It has been known for some time that T cells reactive to a wide variety of alloantigens may be activated during an immune response to a virus in rodents (32)(33)(34). Since then, broad-based cross-reactivity has been described in more detail in LCMV-immune B6 (H-2 b ) mice; four unique LCMV epitopes that were stained by tetramer were found to have a subset of alloresponsive T cells against either H-2 d or H-2 k (35).…”

Section: The Cross-reactive Immune Response: Virus Infection-mediatedmentioning

confidence: 99%

Patients, Pathogens, and Protective Immunity: The Relevance of Virus-Induced Alloreactivity in Transplantation

Koehn

Gangappa

Miller

et al. 2006

The Journal of Immunology

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Successful transplantation requires the establishment of an ongoing state in which there is simultaneous inhibition of the undesired T cell-dependent rejection response and yet retention of the ability to develop effective cell-mediated primary and memory responses to pathogens. The complexity of attaining such a precarious state is underscored by the growing body of evidence that alloreactivity can be profoundly influenced by infections that occur before, concurrent with, or subsequent to an organ transplant. In this review, we explore the growing list of mechanisms that have been identified by which pathogen-host interactions might influence rejection, including the degeneracy of TCR recognition leading to cross-reactive immune responses, the effects of pathogens on innate immune mechanisms, and the potential impact of virally induced lymphopenia.

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“…Nevertheless, it is also quite possible that a single TCR can find multiple different MHC molecules as compatible partners. In fact, T cell clones specific for a protein Ag presented by a self MHC molecule frequently show cross-reactivity to allogeneic MHC (ϩ peptide) (5)(6)(7)(8)(9). TCR may well show similar cross-reactivity (multiple specificity) at the level of positive selection in which lower affinity interaction is crucial.…”

mentioning

confidence: 99%

Cross-Positive Selection of Thymocytes Expressing a Single TCR by Multiple Major Histocompatibility Complex Molecules of Both Classes: Implications for CD4+ versus CD8+ Lineage Commitment

Eshima

Suzuki

Shinohara

2006

The Journal of Immunology

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This study has investigated the cross-reactivity upon thymic selection of thymocytes expressing transgenic TCR derived from a murine CD8+ CTL clone. The Idhigh+ cells in this transgenic mouse had been previously shown to mature through positive selection by class I MHC, Dq or Lq molecule. By investigating on various strains, we found that the transgenic TCR cross-reacts with three different MHCs, resulting in positive or negative selection. Interestingly, in the TCR-transgenic mice of H-2q background, mature Idhigh+ T cells appeared among both CD4+ and CD8+ subsets in periphery, even in the absence of RAG-2 gene. When examined on β2-microglobulin−/− background, CD4+, but not CD8+, Idhigh+ T cells developed, suggesting that maturation of CD8+ and CD4+ Idhigh+ cells was MHC class I (Dq/Lq) and class II (I-Aq) dependent, respectively. These results indicated that this TCR-transgenic mouse of H-2q background contains both classes of selecting MHC ligands for the transgenic TCR simultaneously. Further genetic analyses altering the gene dosage and combinations of selecting MHCs suggested novel asymmetric effects of class I and class II MHC on the positive selection of thymocytes. Implications of these observations in CD4+/CD8+ lineage commitment are discussed.

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Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic cells specifically lyse allogeneic target cells.

Cited by 137 publications

References 14 publications

Generation of virus‐specific cytotoxic T cells in vitro I. Induction conditions of primary and secondary Sendai virus‐specific cytotoxic T cells

Generation of virus‐specific cytotoxic T cells in vitro I. Induction conditions of primary and secondary Sendai virus‐specific cytotoxic T cells

Patients, Pathogens, and Protective Immunity: The Relevance of Virus-Induced Alloreactivity in Transplantation

Cross-Positive Selection of Thymocytes Expressing a Single TCR by Multiple Major Histocompatibility Complex Molecules of Both Classes: Implications for CD4+ versus CD8+ Lineage Commitment

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