Biological significance of liver cell polyploidy: an hypothesis

Uryvaeva, I. V.

doi:10.1016/0022-5193(81)90028-x

Cited by 33 publications

(15 citation statements)

References 37 publications

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“…1B). Normally, the proliferation was realizing due to these cells dividing and this checkpoint of the cell cycle does not inhibit cell functions [3]. Thus, we suggest that a high number of binucleated hepatocytes could be produced as a result of the cell dividing damage (acytokinesis) that could lead to adaptive response to low-dose rate radiation.…”

Section: Resultsmentioning

confidence: 96%

Histologic assessment of regenerating rat liver under low-dose rate radiation exposure

Guryev

2005

International Congress Series

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Section: Resultsmentioning

confidence: 96%

Histologic assessment of regenerating rat liver under low-dose rate radiation exposure

Guryev

2005

International Congress Series

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“…Van Noorden et al [18] remarked that the heterogeneity of the parenchymal cell population should be taken into account with regard not only to the metabolic zona tion but also to the ploidy classes. The phe nomenon of polyploidization of the liver cells has been interpreted as protection against deleterious consequences resulting from aberrant mitoses which could occur during aging and drug metabolism [19].…”

Section: Nucleimentioning

confidence: 99%

Liver Architecture

Sasse

Spornitz

Maly

1992

Enzyme

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The development of liver parenchyma starts from entodermal cells which grow out from the gut into the mesenchyma of the septum transversum. In the definitive organ this close association of epithelial cells (hepatocytes) and mesenchyma-derived nonparenchymal cells is maintained. The liver, and with it each hepatocyte, acts in two directions; the vascular poles of the hepatocytes serve in an ingestive sense, while at their biliary poles secretory functions are exerted. Hepatic microvascularization comprises two afferent vessels (arterial and portal terminal branches), the sinusoids and the terminal hepatic venule. Sinusoidal cells surround the capillaries but also have highly specialized functions with regard to filtration, phagocytosis, fat storage and defense. The autonomic innervation plays an important role in the regulation of metabolic functions. Above the cellular level the proper architecture of the liver parenchyma has been the object of controversial discussions for centuries. The concept of the liver lobule, the portal unit, the liver acinus and other structures are presented and discussed. Finally, the liver parenchyma is described as an irregular interdigitating system of regions related to the terminal blood vessels.

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“…The variability in Feulgen-DNA values found in the fixed, nonlysed nuclei is assumed to occur because of the well-known variability in DNA content due to various ploidy degrees occurring in the adult liver (20)(21)(22)(23)(24)(25)(26). Indeed, the results obtained here revealed for the fixed nuclei a very high standard deviation even surpassing the half the IOD arithmetic means (X 5 38.20; S 5 19.80) ( Table 2), which is in agreement with more than one ploidy degree being present (20)(21)(22)(23)(24)(25)(26). The variation in DNA content retained in the hepatocyte nuclear remnants may be due to a structural constraint imposed by part of the chromatin organization possibly because the examined nuclei were engaged into different functional activities (8,9).…”

Section: Resultsmentioning

confidence: 99%

Nucleus image properties assessed by video image analysis in mouse hepatocytes under a short lysis for extended chromatin fiber formation

2006

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Background: How much DNA remains in mouse hepatocyte nuclei after extended chromatin fiber (ECF) formation or whether this content varies within the nuclear population is not known. This information could be relevant to understanding chromatin extensibility as related to chromatin organization, possibly associated with variable nuclear activities in hepatocytes. Methods: A protocol for ECF formation under the gravity action, image analysis of Feulgen-stained unfixed mouse hepatocyte remnants, and DAPI fluorescence were used. Results: Areas, shape, Feulgen-DNA amounts, and chromatin texture were affected in unfixed, lysed nuclei. The Feulgen-DNA values in nuclear remnants represented 37% of the content in fixed, nonlysed nuclei in terms of median values; the coefficient of variation of Feulgen-DNA values in the nuclear remnants was much higher than those in controls. Enhancement in DAPI fluorescence was

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Biological significance of liver cell polyploidy: an hypothesis

Cited by 33 publications

References 37 publications

Histologic assessment of regenerating rat liver under low-dose rate radiation exposure

Histologic assessment of regenerating rat liver under low-dose rate radiation exposure

Liver Architecture

Nucleus image properties assessed by video image analysis in mouse hepatocytes under a short lysis for extended chromatin fiber formation

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