Biological studies on Brazilian plants used in wound healing

Schmidt, Cleber Alberto; Fronza, Márcio; Goettert, Márcia Inês; Geller, Fabiana Cristina; Luik, Sabine; Flores, Érico M.M.; Bittencourt, Celso Figueiredo; Zanetti, Gilberto Dolejal; Heinzmann, Berta Maria; Laufer, Stefan; Merfort, Irmgard

doi:10.1016/j.jep.2009.01.022

Cited by 131 publications

(123 citation statements)

References 60 publications

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“…The results observed in this work for the trumpet extract corroborate with Schmidt et al (2009) who found that the ethanolic and hexanic extracts of this plant did not inhibit the growth of Bacillus subtilis in the agar diffusion test. The main compounds found in B. suaveolens are tropanic alkaloids (e.g., scopolamine) that act in defense against herbivores (ALVES et al, 2007), and show a hallucinogenic effect on humans.…”

Section: Activity Of Aqueous Plant Extracts On Crystals Of B Thuringsupporting

confidence: 90%

Activity of plant aqueous extracts on Bacillus thuringiensis and their interactions on Anticarsia gemmatalis (Lepidoptera: Erebinae)

Vilani

Lozano

Potrich

et al. 2017

SCA

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The association of plant extracts and B. thuringiensis may be important in situations that control of different insects species is required and/or control of insects in various development stages. However, extracts may have different effects on B. thuringiensis, compromising their mode of action. Thus, the objective of this study was to evaluate the activity of aqueous plant extracts on Bacillus thuringiensis subsp. kurstaki (Btk) and their interactions on Anticarsia gemmatalis (Lepidoptera: Erebinae). Cherry plant extracts (Eugenia uniflora), pepper (Capsicum baccatum), trumpet (Brugmansia suaveolens) and grape japan (Hovenia dulcis), were used at 5% concentrations. For compatibility studies, the extracts were mixed with Thuricide® (Btk) and the parameters evaluated were Colony Formation Units (CFU mL-1) for spores and, the A. gemmatalis mortality for crystals. The cherry extracts, pepper, and japan grape completely inhibited the CFU ml-1 of Btk and the cherry extract alone negatively affected the toxicity of Btk crystals, with significantly lower mortality of A. gemmatalis (20.40%) than that observed in the control with only Btk (79.44%). In the association between cherry, pepper, and grape japan extracts with B. thuringiensis, the extracts exhibited a negative effect in the formation of CFU. The cherry extract demonstrated a negative effect on crystals action.

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Section: Activity Of Aqueous Plant Extracts On Crystals Of B Thuringsupporting

confidence: 90%

Activity of plant aqueous extracts on Bacillus thuringiensis and their interactions on Anticarsia gemmatalis (Lepidoptera: Erebinae)

Vilani

Lozano

Potrich

et al. 2017

SCA

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“…Schmidt and coworkers (Schmidt et al, 2009) reported these aspects on screening studies focusing on 24 extracts prepared from twelve plants which are used in traditional South Brazilian medicine. The plant species belong to different families and are expected to contain different effective compounds.…”

Section: Discussionmentioning

confidence: 99%

In vitro evaluation of antioxidant, anxiolytic and antidepressant-like effects of the Bellis perennis extract

Marques¹,

Melo²,

Freitas³

2012

Rev. bras. farmacogn.

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Acute toxicity, antioxidant activity in vitro and general pharmacological effects of the fl ower crude ethanolic extract of Bellis perennis L., Asteraceae, a popular medicine used in South America, were investigated in mice. The oral route LD50 value was found 2.31 g/kg. Oral administration at doses 50, 100 and 150 mg/ kg of the extract neither caused significant changes in general behavior nor led to toxic symptoms. Anxiolytic-like properties were studied in the open fi eld test and the possible antidepressant-like actions were evaluated in the forced swimming test (FST). There is a signifi cant decrease in the number of crossings at all dosages mentioned above, but no sedative effects at any dosages when compared to controls. In the FST, the extract dosage of 150 mg/kg was effective in reducing immobility, along with a signifi cant increase in swimming time. The ethanolic extract showed strong antioxidant potential in vitro, through the removal capacity against hydroxyl radicals and nitric oxide as well as prevented the formation of reactive substances to thiobarbituric acid (TBARS). Together, these results indicate that the ethanolic extract has effect on central nervous system, which might due to its antioxidant property, as demonstrated in vitro methods used. These results suggest that some of the components in ethanolic extract of B. perennis, such as alkaloids, phenolic compounds and fl avonoids may have antioxidant, anxiolytic and antidepressant-like properties. Additional investigations are in progress.

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“…As feridas resultam de uma agressão física à pele que causa uma abertura ou ruptura da mesma originando uma lesão tecidual (SCHMIDT et al, 2009). Logo após a lesão tem início o processo de cicatrização, um processo fisiológico que envolve uma complexa sequência de interações entre vários tipos celulares e citocinas com o objetivo de devolver ao tecido danificado sua função e integridade (SCHMIDT et al, 2009;PATHER et al, 2010).…”

Section: Introductionunclassified

“…Logo após a lesão tem início o processo de cicatrização, um processo fisiológico que envolve uma complexa sequência de interações entre vários tipos celulares e citocinas com o objetivo de devolver ao tecido danificado sua função e integridade (SCHMIDT et al, 2009;PATHER et al, 2010).…”

Section: Introductionunclassified

Influência do Extrato Hidroetanólico das Folhas de Tropaeolum majus na Restauração Tecidual em Lesões Cutâneas

Correa¹,

Monteiro²,

Pavanelli³

et al. 2016

SaudPesq

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RESUMO:O presente estudo teve como objetivo avaliar a ação cicatrizante do extrato hidroetanólico de folhas de Tropaeolum majus em lesões cutâneas em ratos. Para isso foram utilizados 15 ratos Wistar distribuídos em 3 grupos denominados de G7, G14 e G21, de acordo com o período de observação em 7, 14 e 21 dias após o procedimento cirúrgico. Na região dorsal de cada animal foram realizadas duas feridas de 1 cm de diâmetro, sendo a da esquerda tratada com gel base de Carbopol, e a da direita com gel de Tropaeolum majus. Os tratamentos nas lesões ocorreram diariamente nos períodos citados. Realizou-se estudo comparativo entre os dois grupos por meio da análise micro e macroscópica. Observou-se formação de crosta em todas as feridas até o sétimo dia. Na avaliação histológica, as lesões tratadas com o extrato de Tropaeolum majus apresentaram uma menor quantidade de infiltrado inflamatório e de proliferação fibloblástica com relação às lesões tratadas com o gel base e uma maior colageneização bem como mais acentuada angiogênese no 7º, 14º e 21º dia do pós-operatório. Conclui-se que o extrato hidroetanólico de folhas de Tropaeolum majus promoveu melhora do processo de cicatrização por aumento da formação de neovasos e colageneização. PALAVRAS-CHAVE:Cicatrização; Plantas Medicinais; Tropaeolum majus. INFLUENCE OF HYDROETHANOLIC EXTRACT FROM THE LEAVES OF Tropaeolum majus FOR TISSUE RESTORATION OF SKIN LESIONS ABSTRACT:The healing activity of the hydroethanolic extract of Tropaeolum majus leaves on rats´ skin lesions is provided. Fifteen Wistar rats were used, distributed in three groups, G7, G14 and G21, according to observation period 7, 14 and 21 days after surgery. Two wounds, diameter 1 cm, on the dorsal region of each animal, were treated with Carbopol gel on the left side and by Tropaeolum majus on the right side. Lesions were treated daily during the periods above. A comparative study was undertaken between the two groups by microand macroscopy. The formation of a wound scab on all wounds up to the seventh day was observed. Histological assessment revealed that lesions treated with Tropaeolum majus extract had a lower inflammatory infiltrate rate and fibroblastic proliferation when compared to lesions treated with gel, coupled to a greater collagenization and deeper angiogenesis on the 7 th , 14 th and 21 st day after surgery. Results showed that hydroethanolic extract of Tropaeolum majus leaves caused a better improvement in the healing process through the increase in the formation of neo-vases and collagenization.

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Biological studies on Brazilian plants used in wound healing

Cited by 131 publications

References 60 publications

Activity of plant aqueous extracts on Bacillus thuringiensis and their interactions on Anticarsia gemmatalis (Lepidoptera: Erebinae)

Activity of plant aqueous extracts on Bacillus thuringiensis and their interactions on Anticarsia gemmatalis (Lepidoptera: Erebinae)

In vitro evaluation of antioxidant, anxiolytic and antidepressant-like effects of the Bellis perennis extract

Influência do Extrato Hidroetanólico das Folhas de Tropaeolum majus na Restauração Tecidual em Lesões Cutâneas

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