Biological tailoring of adjuvant radiotherapy in head and neck and oral malignancies – The potential role of p53 and eIF4E as predictive parameters

Joseph, Bindhu; Kumar, Rekha V.; Champaka, G; Shenoy, Ashok M.; Sabitha, K.S.; Lokesh, V.; Ramesh, C.; Vijay, C R

doi:10.4103/ijc.ijc_56_18

Cited by 5 publications

(7 citation statements)

References 10 publications

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“…This occurs mainly through the action of carcinogenic agents from smoking and alcohol consumption [20,25]. TP53 mutations are considered an early event in carcinogenesis of head and neck SCC [19][20][21][25][26][27]. TP53 mutations have been identified in 70.4% of head and neck cancer tumors [21][22][23].…”

Section: Discussionmentioning

confidence: 99%

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P53 And P16 Protein Expression and Survival in Patients with Squamous Cell Carcinoma of the Oral Cavity

C Vidal

2024

OJOR

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Section: Discussionmentioning

confidence: 99%

“…Nevertheless, favorable results with good treatment response have been reported in the presence of increased expression of p53 protein [24]. Increased p53 expression in SCC is closely related to smoking and alcohol consumption [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

P53 And P16 Protein Expression and Survival in Patients with Squamous Cell Carcinoma of the Oral Cavity

C Vidal

2024

OJOR

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“…Radiation delivery technique and the type of energy use are not the only factors which are responsible in determining the response of a tumour to the treatment given. Apart from tumour stage, there are some other factors, influencing the response of tumour to the radiation treatment viz radiobiological behaviour of the tumour, degree of differentiation, mitotic activity, hypoxia and expression of growth factors [14]. However, 3DCRT technique is relatively easy to be implemented and is cost effective as well [15].…”

Section: Discussionmentioning

confidence: 99%

Correlation of 3DCRT and Open Field Treatment Techniques in Advanced Head and Neck Cancer Patients Treated by Chemoradiation

2022

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Background: Multimodality treatment is required for the management of head and neck cancer. Functional impairment and toxicities associated with surgery and radiation accentuate the need to develop innovative therapeutic strategies in the management of these patients to improve survival and reduce toxicity. In this study, we have compared treatment effects in patients of advanced head and neck squamous cell cancer treated by open field and 3DCRT treatment planning techniques.Objective: This study aims to evaluate open field and 3DCRT treatment planning techniques in advanced head and neck squamous cell cancer patients managed by chemoradiation in the scenario of limited resources. Material and Methods:In this analytical study, 40 histologically proven unresectable advanced squamous cell carcinoma patients of oropharynx and larynx were allocated in two groups to receive 70 Gy in 35 fractions in 7 weeks with concurrent cisplatinum35 mg/m 2 weekly either with open-field technique or three dimensional conformal radiotherapy (3DCRT) by ElektaSynergy linear accelerator. Target volume coverage and dose received by organ at risk (OARs) were compared. Clinical outcome in terms of response and toxicities is also evaluated in this study. Results:Plans with best possible coverage of the target volume were obtained.No significant difference was found in the dose received by the spinal cord; however, it was possible to prevent higher dose to brain stem with 3DCRTin node negative patients of oropharynx cancer and larynx cancer. Skin toxicities were significantly lower in 3DCRT arm. Conclusion:In low resource settings with increased burden of locally advanced disease, both open-field and 3DCRT treatment techniques are comparable in terms of target coverage, OARs preservation, toxicity and treatment response.

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“…The EIF-4F complex binds to the cap structure at the 5' end of target mRNA, which promotes the initiation of translation. EIF-4E may regulate the translation of numerous proteins, including cyclin D-MYC and RAS, which are closely associated with cancer cell growth, proliferation and cell cycle regulation, thereby affecting cancer progression ( 37 , 38 ). S6K1 is a serine/threonine kinase with multiple phosphorylation sites that is directly or indirectly regulated by mTORC1 and participates in the regulation of autophagy ( 30 ).…”

Section: Signaling Pathways In Autophagy and Tumorsmentioning

confidence: 99%

Autophagy-related signaling pathways are involved in cancer (Review)

Chen

Gao

2021

Exp Ther Med

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Autophagy is a self-digestion process in cells that can maintain energy homeostasis under normal circumstances. However, misfolded proteins, damaged mitochondria and other unwanted components in cells can be decomposed and reused via autophagy in some specific cases (including hypoxic stress, low energy states or nutrient deprivation). Therefore, autophagy serves a positive role in cell survival and growth. However, excessive autophagy may lead to apoptosis. Furthermore, abnormal autophagy may lead to carcinogenesis and promote tumorigenesis in normal cells. In tumor cells, autophagy may provide the energy required for excessive proliferation, promote the growth of cancer cells, and evade apoptosis caused by certain treatments, including radiotherapy and chemotherapy, resulting in increased treatment resistance and drug resistance. On the other hand, autophagy leads to an insufficient nutrient supply in cancer cells and the destruction of energy homeostasis, thereby inducing cancer cell apoptosis. Therefore, understanding the mechanism of the double-edged sword of autophagy is crucial for the treatment of cancer. The present review summarizes the signaling pathways and key factors involved in autophagy and cancer to provide possible strategies for treating tumors.

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Biological tailoring of adjuvant radiotherapy in head and neck and oral malignancies – The potential role of p53 and eIF4E as predictive parameters

Cited by 5 publications

References 10 publications

P53 And P16 Protein Expression and Survival in Patients with Squamous Cell Carcinoma of the Oral Cavity

P53 And P16 Protein Expression and Survival in Patients with Squamous Cell Carcinoma of the Oral Cavity

Correlation of 3DCRT and Open Field Treatment Techniques in Advanced Head and Neck Cancer Patients Treated by Chemoradiation

Autophagy-related signaling pathways are involved in cancer (Review)

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