Biological versus chronological ovarian age: implications for assisted reproductive technology

Alviggi, Carlo; Humaıdan, Peter; Howles, Colin M.; Tredway, Donald R.; Hillier, Stephen G.

doi:10.1186/1477-7827-7-101

Cited by 138 publications

(107 citation statements)

References 140 publications

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“…However IVF makes no sense at all as a treatment for age-dependent female infertility. In keeping with this conclusion, live births following assisted conception therapy show exactly the same agedependent decline with maternal age as we see in the naturally conceived population (Alviggi et al 2009). …”

Section: Age and Reproduction: The Female Perspectivesupporting

confidence: 72%

Age, the environment and our reproductive future: bonking baby boomers and the future of sex

Aitken

2014

Reproduction

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There has never been a greater need for scientists trained in reproductive science. Most developed countries are witnessing unprecedented rates of recourse to assisted conception sitting cheek-by-jowl with high rates of induced abortion. This article addresses these two incongruous faces of reproductive healthcare. Every year at least 44 million abortions are performed worldwide, many under unsafe and insanitary conditions that carry a significant risk to the lives of women deprived of safe, effective methods for controlling their fertility. Although birth control is a complex issue involving myriad social and political factors, the technical vacuum in this area is significant. Through no fault of the family planning authorities, there have been no radically new methods of fertility control since the oral contraceptive pill was introduced in 1960 and even this contribution to planned parenthood has its roots in the biochemistry of the 1920s and 1930s. Moreover, the pharmaceutical industry has, by and large, turned its back on fundamental research activities in this area. At present, our major investment in reproductive healthcare involves treating ever-increasing numbers of couples with assisted reproductive technologies (ART). However, these treatments are often delivered without critically considering the underlying causes of this condition or seriously contemplating the long-term consequences of the current enthusiasm for such therapy. Significantly, the clinical factors underpinning the commitment of couples to ART include advanced maternal age and a variety of lifestyle factors, such as smoking and obesity, which are known to compromise the developmental potential of the oocyte and DNA integrity in spermatozoa.

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Section: Age and Reproduction: The Female Perspectivesupporting

confidence: 72%

Age, the environment and our reproductive future: bonking baby boomers and the future of sex

Aitken

2014

Reproduction

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“…By the onset of puberty, the number of primordial follicles declines to only 300,000 to 400,000 (6,7). At child-bearing age, the number of primordial follicles decreases steadily at a rate of about 1,000 follicles per month and drops below 1,000 at the average age of 51 years (menopause) (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

The protective effects of human umbilical cord mesenchymal stem cells on damaged ovarian function: A comparative study

Zhang

Xiong

et al. 2016

BST

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“…Studies have shown that ovarian ageing affecting oocyte quality and fecundity can occur independently of chronological age [17,18]. Advancing age in women is associated with reduced oocyte quality, however biological age, which can be defined as a woman's specific reproductive competence or ovarian reserve, can be entirely separate to her chronological age.…”

Section: Biological Ageing Vs Chronological Ageingmentioning

confidence: 99%

What is the best treatment option for infertile women aged 40 and over?

Armstrong

Akande

2013

J Assist Reprod Genet

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Purpose To summarise the causes of decreased fecundity with age and review chronological vs biological ovarian ageing. To explore the clinician's means of assessing a woman's ovarian reserve. To review the recent literature on the effectiveness of different assisted reproductive technology (ART) techniques for women aged 40 and over and offer a single best treatment option. Methods Pubmed and google scholar were searched for relevant articles using key words. Data were extracted based on authors, year, aims, sample and results. Results Success rates for women aged 40 or over with clomiphene, IUI, IUI with FSH are all extremely low, at less than 1 % live birth per cycle. However, IVF offers a success rate of around 13.7 % per cycle. Conclusion An exploration of the effectiveness of available treatment options for older infertile women using their own gametes suggests that IVF offers the best prospects of success. Attempting treatments other than IVF will delay conception unnecessarily.

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Biological versus chronological ovarian age: implications for assisted reproductive technology

Cited by 138 publications

References 140 publications

Age, the environment and our reproductive future: bonking baby boomers and the future of sex

Age, the environment and our reproductive future: bonking baby boomers and the future of sex

The protective effects of human umbilical cord mesenchymal stem cells on damaged ovarian function: A comparative study

What is the best treatment option for infertile women aged 40 and over?

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