Biologically Active Acetylenic Amino Alcohol and <i>N</i>-Hydroxylated 1,2,3,4-Tetrahydro-β-carboline Constituents of the New Zealand Ascidian <i>Pseudodistoma opacum</i>

Wang, Jiayi; Pearce, A. Norrie; Chan, Sy; Taylor, Richard B.; Page, Michael; Valentin, Alexis; Bourguet‐Kondracki, Marie‐Lise; Dalton, James; Wiles, Siouxsie; Copp, Brent R.

doi:10.1021/acs.jnatprod.5b00770

Cited by 34 publications

(59 citation statements)

References 22 publications

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“…M. tuberculosis reference strain ATCC 27294 and M. tuberculosis clinical isolate Rangipo N were similarly tagged and designated BSG001 and BSG002, respectively (Colangeli et al, 2014; Wang et al, 2016). All strains were grown at 37 °C, with 200 rpm agitation where appropriate.…”

Section: Methodsmentioning

confidence: 99%

The tuberculocidal activity of polyaniline and functionalised polyanilines

Robertson

Dalton

Wiles

et al. 2016

PeerJ

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Tuberculosis is considered a leading cause of death worldwide. More than 95% of cases and deaths occur in low-and middle-income countries. In resource-limited countries, hospitals often lack adequate facilities to manage and isolate patients with infectious tuberculosis (TB), relying instead on personal protective equipment, such as facemasks, to reduce nosocomial transmission of the disease. Facemasks impregnated with an antimicrobial agent may be a cost-effective way of adding an extra level of protection against the spread of TB by reducing the risk of disease transmission. Conducting polymers, such as polyaniline (PANI), and their functionalised derivatives are a novel class of antimicrobial agents with potential as non-leaching additives to provide contamination resistant surfaces. We have investigated the antimicrobial action of PANI and a functionalised derivative, poly-3-aminobenzoic acid (P3ABA), against mycobacteria and have determined the optimal treatment time and concentration to achieve significant knockdown of Mycobacterium smegmatis and Mycobacterium tuberculosis on an agar surface. Results indicated that P3ABA is a potential candidate for use as an anti-tuberculoid agent in facemasks to reduce TB transmission.

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Section: Methodsmentioning

confidence: 99%

The tuberculocidal activity of polyaniline and functionalised polyanilines

Robertson

Dalton

Wiles

et al. 2016

PeerJ

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“…In this study we used M. tuberculosis BSG001 (Wang et al, 2016), a stable bioluminescent derivative of H37Rv transformed with the integrating plasmid pMV306hspLuxABG13CDE (Andreu et al, 2010). Cultures of BSG001 were grown at 37 °C with gentle shaking (100 rpm) in Middlebrook 7H9 broth (Fort Richard, Auckland) supplemented with 10% Middlebrook ADC enrichment media (Fort Richard) and 0.5% glycerol (Sigma-Aldrich), or on 7H11 agar (Fort Richard) supplemented with 10% Middlebrook OADC enrichment media (Fort Richard) and 0.5% glycerol.…”

Section: Methodsmentioning

confidence: 99%

Effect of common and experimental anti-tuberculosis treatments onMycobacterium tuberculosisgrowing as biofilms

Dalton

Phummarin

et al. 2016

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Much is known regarding the antibiotic susceptibility of planktonic cultures of Mycobacterium tuberculosis, the bacterium responsible for the lung disease tuberculosis (TB). As planktonically-grown M. tuberculosis are unlikely to be entirely representative of the bacterium during infection, we set out to determine how effective a range of anti-mycobacterial treatments were against M. tuberculosis growing as a biofilm, a bacterial phenotype known to be more resistant to antibiotic treatment. Light levels from bioluminescently-labelled M. tuberculosis H37Rv (strain BSG001) were used as a surrogate for bacterial viability, and were monitored before and after one week of treatment. After treatment, biofilms were disrupted, washed and inoculated into fresh broth and plated onto solid media to rescue any surviving bacteria. We found that in this phenotypic state M. tuberculosis was resistant to the majority of the compounds tested. Minimum inhibitory concentrations (MICs) increased by 20-fold to greater than 1,000-fold, underlying the potential of this phenotype to cause significant problems during treatment.

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“…Wang et al actioned the isolation and identification of a new N-hydroxy-1, 2, 3, 4-tetrahydroβ-carboline, together with the first example of an acetylenic 1-amino-2-alcohol lipid, distaminolyne A (1) from ascidian, Pseudodistoma opacum. The compounds showed moderate activity against pathogens and compound 2 displayed antimalarial activity against a chloroquine-resistant strain (FcB1) of P. falciparum (IC 50 3.82 ± 0.2 µM) [125]. Another chloroquine-resistant Dd2 strain of P. falciparum was very susceptible to known antimalarial sesquiterpenoids (Table 2) produced by marine sponge, Hyrtios erectus [4].…”

Section: Marine-derived Antimicrobial Compounds From Invertebratesmentioning

confidence: 99%

Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa

et al. 2020

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As the search for new antibiotics continues, the resistance to known antimicrobial compounds continues to increase. Many researchers around the world, in response to antibiotics resistance, have continued to search for new antimicrobial compounds in different ecological niches such as the marine environment. Marine habitats are one of the known and promising sources for bioactive compounds with antimicrobial potentials against currently drug-resistant strains of pathogenic microorganisms. For more than a decade, numerous antimicrobial compounds have been discovered from marine environments, with many more antimicrobials still being discovered every year. So far, only very few compounds are in preclinical and clinical trials. Research in marine natural products has resulted in the isolation and identification of numerous diverse and novel chemical compounds with potency against even drug-resistant pathogens. Some of these compounds, which mainly came from marine bacteria and fungi, have been classified into alkaloids, lactones, phenols, quinones, tannins, terpenes, glycosides, halogenated, polyketides, xanthones, macrocycles, peptides, and fatty acids. All these are geared towards discovering and isolating unique compounds with therapeutic potential, especially against multidrug-resistant pathogenic microorganisms. In this review, we tried to summarize published articles from 2015 to 2019 on antimicrobial compounds isolated from marine sources, including some of their chemical structures and tests performed against drug-resistant pathogens.

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Biologically Active Acetylenic Amino Alcohol and N-Hydroxylated 1,2,3,4-Tetrahydro-β-carboline Constituents of the New Zealand Ascidian Pseudodistoma opacum

Cited by 34 publications

References 22 publications

The tuberculocidal activity of polyaniline and functionalised polyanilines

The tuberculocidal activity of polyaniline and functionalised polyanilines

Effect of common and experimental anti-tuberculosis treatments onMycobacterium tuberculosisgrowing as biofilms

Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa

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