Biologically Active and Antimicrobial Peptides from Plants

Salas, Carlos; Badillo-Corona, Jesús Agustín; Ramírez-Sotelo, Guadalupe; Oliver-Salvador, Carmen

doi:10.1155/2015/102129

Cited by 139 publications

(78 citation statements)

References 131 publications

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“…HSV-1 virucidal activity observed in a 2 kDa antiviral peptide isolated from Sorghum bicolor seeds may be explained by the capacity of the peptide to bind and mask essential viral envelope proteins [67]. In fact, modulation in the activity of enzymes involved in viral infection and replication appears to be one of the most prominent mechanisms utilized by plant peptides to inhibit viral proliferation [68].…”

Section: Avps Derived From Plantsmentioning

confidence: 99%

Antiviral peptides as promising therapeutic drugs

Boas

Campos

Berlanda

et al. 2019

Cell. Mol. Life Sci.

251

175

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While scientific advances have led to large-scale production and widespread distribution of vaccines and antiviral drugs, viruses still remain a major cause of human diseases today. The ever-increasing reports of viral resistance and the emergence and re-emergence of viral epidemics pressure the health and scientific community to constantly find novel molecules with antiviral potential. This search involves numerous different approaches, and the use of antimicrobial peptides has presented itself as an interesting alternative. Even though the number of antimicrobial peptides with antiviral activity is still low, they already show immense potential to become pharmaceutically available antiviral drugs. Such peptides can originate from natural sources, such as those isolated from mammals and from animal venoms, or from artificial sources, when bioinformatics tools are used. This review aims to shed some light on antimicrobial peptides with antiviral activities against human viruses and update the data about the already well-known peptides that are still undergoing studies, emphasizing the most promising ones that may become medicines for clinical use.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Section: Avps Derived From Plantsmentioning

confidence: 99%

Antiviral peptides as promising therapeutic drugs

Boas

Campos

Berlanda

et al. 2019

Cell. Mol. Life Sci.

251

175

View full text Add to dashboard Cite

show abstract

“…Considering the high similarity between different AMPs in terms of their toxicity and antimicrobial activity, only two major groups of antimicrobial peptides, in particular thionins and cyclotides, are discussed below. For more information with respect to the antimicrobial activity of AMPs we refer to some recent review papers (Goyal and Mattoo, 2014;Salas et al, 2015).…”

Section: Antimicrobial Peptidesmentioning

confidence: 99%

Toxic proteins in plants

2015

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Plants have evolved to synthesize a variety of noxious compounds to cope with unfavorable circumstances, among which a large group of toxic proteins that play a critical role in plant defense against predators and microbes. Up to now, a wide range of harmful proteins have been discovered in different plants, including lectins, ribosome-inactivating proteins, protease inhibitors, ureases, arcelins, antimicrobial peptides and pore-forming toxins. To fulfill their role in plant defense, these proteins exhibit various degrees of toxicity towards animals, insects, bacteria or fungi. Numerous studies have been carried out to investigate the toxic effects and mode of action of these plant proteins in order to explore their possible applications. Indeed, because of their biological activities, toxic plant proteins are also considered as potentially useful tools in crop protection and in biomedical applications, such as cancer treatment. Genes encoding toxic plant proteins have been introduced into crop genomes using genetic engineering technology in order to increase the plant's resistance against pathogens and diseases. Despite the availability of ample information on toxic plant proteins, very few publications have attempted to summarize the research progress made during the last decades. This review focuses on the diversity of toxic plant proteins in view of their toxicity as well as their mode of action. Furthermore, an outlook towards the biological role(s) of these proteins and their potential applications is discussed.

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“…More than 7000 natural peptides have been identified until today (Fosgerau and Hoffmann 2015) and AMPs can be found virtually in all living organisms, from plants and insects to animals (Salas et al 2015). Table 4.1 lists selected examples of these AMPs with anticancer activity.…”

Section: Targeting Cancer Cells Using Natural Peptidesmentioning

confidence: 99%

Anticancer Peptides: Prospective Innovation in Cancer Therapy

Gaspar

Castanho

2016

Host Defense Peptides and Their Potential as Therapeutic Agents

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Current cancer treatments require improvements in selectivity and efficacy. Surgery, radiation, and chemotherapy approaches result in patient's suffering over time due to the development of severe side-effects that simultaneously condition adherence to therapy. Biologically active peptides, in particular antimicrobial peptides (AMPs), are versatile molecules in terms of biological activities. The cytotoxic activities of several AMPs turn this group of molecules into an amazing pool of new templates for anticancer drug development. However, several unmet challenges limit application of peptides in cancer therapy. The mechanism(s) of action of the peptides need better description and understanding, and innovative targets have to be discovered and explored, facilitating drug design and development. In this chapter, we explore the natural occurring AMPs as potential new anticancer peptides (ACPs) for cancer prevention and treatment. Their modes of action, selectivity to tumor compared to normal cells, preferential targets, and applications, but also their weaknesses, are described and discussed.

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Biologically Active and Antimicrobial Peptides from Plants

Cited by 139 publications

References 131 publications

Antiviral peptides as promising therapeutic drugs

Antiviral peptides as promising therapeutic drugs

Toxic proteins in plants

Anticancer Peptides: Prospective Innovation in Cancer Therapy

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