Biologically active branched-chain aminocyclopentane tetraols from d-galactose

Schalli, Michael; Weber, Patrick; Nasseri, Seyed A.; Gomez, Ana Torvisco; Müller, Philipp; Stütz, Arnold; Withers, Stephen G.; Wolfsgruber, Andreas; Wrodnigg, Tanja

doi:10.1007/s00706-019-02428-0

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…Among all contaminants of the water distribution system, such as inorganic and organic compounds, microbial contamination can lead to severe consequences for public health [ 61 , 62 , 63 , 64 , 65 ]. The intake of bacteria during the process of filling and capping bottles may lead to a reduced quality of bottled water, which is of interest to consumers as well as to its producers [ 29 , 66 ].…”

Section: Discussionmentioning

confidence: 99%

Dissolved Carbon Dioxide: The Lifespan of Staphylococcus aureus and Enterococcus faecalis in Bottled Carbonated Mineral Water

Schalli

Platzer

Schmutz

et al. 2023

Biology

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During the process of mineral water production, many possible contamination settings can influence the quality of bottled water. Microbial contamination can originate from different sources, for example, the ambient air, the bottles, the caps, and from the bottling machine itself. The aim of this study was to investigate the influence of three different carbon dioxide (CO2) concentrations (3.0 g/L, 5.5 g/L, and 7.0 g/L; 20 bottles each) in bottled mineral water on the bacterial growth of Staphylococcus aureus (S. aureus) and Enterococcus faecalis (Ent. faecalis). The examined mineral water was artificially contaminated before capping the bottles inside the factory. After a specific number of days, water samples were taken from freshly opened bottles and after filtration (100 mL), filters were placed on Columbia Agar with 5% Sheep blood to cultivate S. aureus and Slanetz and Bartley Agar to cultivate Ent. faecalis. The respective colony-forming units (CFU) were counted after incubation times ranging from 24 to 120 h. Colony-forming units of S. aureus were not detectable after the 16th and 27th day, whereas Ent. faecalis was not cultivable after the 5th and 13th day when stored inside the bottles. The investigation of the bottles that were stored open for a certain amount of time with CO2 bubbling out showed only single colonies for S. aureus after the 5th day and no CFUs for Ent. faecalis after the 17th day. A reduction in the two investigated bacterial strains during storage in carbonated mineral water bottles means that a proper standardized disinfection and cleaning procedure, according to valid hygiene standards of industrial bottling machines, cannot be replaced by carbonation.

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Section: Discussionmentioning

confidence: 99%

Dissolved Carbon Dioxide: The Lifespan of Staphylococcus aureus and Enterococcus faecalis in Bottled Carbonated Mineral Water

Schalli

Platzer

Schmutz

et al. 2023

Biology

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Synthesis of Isofagomine Derivatives as New Fluorescence pH Indicators/Glycosidase Inhibitors

et al. 2020

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Inhibitor protonation of azasugars of the isofagomine type when bound to enzyme can be investigated using photon induced electron transfer (PET) quenching of an attached fluorophore. For this purpose, Isofagomine, iso‐d‐galacto‐fagomine, and iso‐l‐gulo‐fagomine were converted to N‐(10‐chloroanthracenenyl‐9‐alkyl) derivatives where the alkyl group contained one, two, or three methylene groups. The new derivatives displayed pH dependent fluorescence; as the ammonium forms they were fluorescent, while 90–99 % of the fluorescence was quenched in the amine forms. The 3 isofagomine derivatives were competitive inhibitors of T. Maritima Ι‐glucosidase with Ki values from 0.37–4.6ΤM. Similarly, the iso‐d‐galacto‐fagomines inhibited A. Niger Ι‐galactosidase with Ki values from 63–2000 nm. When bound to the enzymes the inhibitors displayed between 1–15 % fluorescence.

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Biologically active branched-chain aminocyclopentane tetraols from d-galactose

Cited by 2 publications

References 45 publications

Dissolved Carbon Dioxide: The Lifespan of Staphylococcus aureus and Enterococcus faecalis in Bottled Carbonated Mineral Water

Dissolved Carbon Dioxide: The Lifespan of Staphylococcus aureus and Enterococcus faecalis in Bottled Carbonated Mineral Water

Synthesis of Isofagomine Derivatives as New Fluorescence pH Indicators/Glycosidase Inhibitors

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