Biologically active Chitosan/ZnO/Acalypha indica leaf extract biocomposite: An investigation of antibacterial, cell proliferation and cell migration aptitude for wound healing application

Sakthiguru, Nagarajan; Manimohan, Murugaiyan; Jaganathan, G.; Manivannan, K.; Sithique, Mohamed Aboobucker

doi:10.1016/j.scp.2020.100357

Cited by 8 publications

(3 citation statements)

References 50 publications

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“…These processes of cell division and migration cause the formation of dense cellular adhesions at the injured site. The whole process starts when the epithelial monolayer is broken down by giving the cells more cytokines and growth factors 125 . Hence, the in vitro wound healing test was applied to investigate the cell migration potential of the scaffolds.…”

Section: Resultsmentioning

confidence: 99%

“…The whole process starts when the epithelial monolayer is broken down by giving the cells more cytokines and growth factors. 125 Hence, the in vitro wound healing test was applied to investigate the cell migration potential of the scaffolds. It was clear that the process of spreading and migrating starts with an increase in time.…”

Section: In Vitro Wound-healing Assaymentioning

confidence: 99%

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Equisetum arvenseand nano zinc oxide‐infused polycaprolactone scaffolds: A multifaceted approach for antibacterial, antioxidant, and hemocompatible wound dressing

Chinijani,

Afza,

Yousefiasl

et al. 2024

Polymer Engineering & Sci

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An appropriate skin tissue‐engineered scaffold can act promptly to combat microbial infection and preserve the wound throughout all phases of healing. To achieve sufficient healing, scaffolds should also promote cell proliferation and regeneration. Therefore, it has become essential to develop skin tissue engineering scaffolds that mimic the extracellular matrices of the skin, provide a high porosity scaffold structure, and act as an antimicrobial protection during wound healing. In this study, the polycaprolactone (PCL) electrospun scaffold was modified with optimal amounts of zinc oxide nanoparticles (ZnO) and Equisetum arvense (EA) herbal extract for potential application as antibacterial and wound healing scaffolds. Full characterization was carried out for fabricated scaffolds before in‐vitro assessments. FTIR spectroscopy and SEM images verified the successful substitution of nanofibers with EA and ZnO. These substitutions increased the hydrophilicity compared to the PCL scaffold. According to the results, the PCL/ZnO/EA fabricated scaffold was hemocompatible and non‐cytotoxic, in addition to allowing proper cell attachment. Effective antibacterial efficiency against Gram‐positive and Gram‐negative bacteria was also observed in this sample. Finally, the in vitro wound healing assay indicated that the addition of ZnO and EA improves the wound healing capacity of the scaffolds. The results indicate the potential of the developed scaffolds to prevent wound contamination and the complications of chronic infection.Highlights Optimal concentrations of zinc oxide nanoparticles (ZnO) and Equisetum arvense (EA) were incorporated into electrospun polycaprolactone (PCL) nanofibers for potential wound dressing applications. The fabricated nanofibrous wound dressings offer a multitude of structural features in biomaterials. PCL fibers enable the controlled release of both ZnO and EA. The fabricated scaffolds exhibit favorable antibacterial, and antioxidant properties while maintaining biocompatibility and hemocompatibility.

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Section: Resultsmentioning

confidence: 99%

Section: In Vitro Wound-healing Assaymentioning

confidence: 99%

Equisetum arvenseand nano zinc oxide‐infused polycaprolactone scaffolds: A multifaceted approach for antibacterial, antioxidant, and hemocompatible wound dressing

Chinijani,

Afza,

Yousefiasl

et al. 2024

Polymer Engineering & Sci

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“…Moreover, plants extracts can be loaded into various polymers, enhancing hemostasis and speeding up tissue regeneration [78,79], or coated on the polymer support, thus being a simple, reproducible and cost-effective approach [80]. For wound healing dressings in the form of hydrogels, natural extracts can modify the morphology of the bio-composite by suppressing the crystallinity behavior [81] an important aspect being represented by the condition for the pores of the support material to have proper dimensions, to achieve the release of the encapsulated drugs and molecules, as well as to prevent the bacterial invasion [82].…”

Section: Coating Materials For Biomedical Applicationsmentioning

confidence: 99%

Natural Ingredients in Functional Coatings—Recent Advances and Future Challenges

Fierăscu

Chican

2021

Coatings

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In recent decades, coating materials have gained researchers’ interest, finding applications in different areas such as antimicrobial coatings for biomedical applications, coatings for increasing the shelf-life of commercial products, or coatings for the conservation of cultural heritage artifacts. The use of new types of coating materials based on natural ingredients can lead to the removal of harmful chemicals and contribute to the development of materials having different and promising properties. New challenges can appear both in the production process, as well as in the case of final application, when coating materials must be applied on various supports. The present review paper aims to be a critical discussion regarding the possibility of using natural ingredients as functional coatings, and to prove that the same material can be used in different fields, from the biomedical to environmental, or from cultural heritage protection to the food and cosmetic industries. The paper is based on the newest published studies, and its main goal is to be an inspiration source for researchers, in order to create more functional and applicable composite coatings in specific fields.

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Chitosan PVA and Acalypha indica-based nanoformulation for antimicrobial activity against Staphylococcus aureus

Priyamvadan,

Thirugnanam,

Majeed

et al. 2023

Polym. Bull.

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Biologically active Chitosan/ZnO/Acalypha indica leaf extract biocomposite: An investigation of antibacterial, cell proliferation and cell migration aptitude for wound healing application

Cited by 8 publications

References 50 publications

Equisetum arvenseand nano zinc oxide‐infused polycaprolactone scaffolds: A multifaceted approach for antibacterial, antioxidant, and hemocompatible wound dressing

Equisetum arvenseand nano zinc oxide‐infused polycaprolactone scaffolds: A multifaceted approach for antibacterial, antioxidant, and hemocompatible wound dressing

Natural Ingredients in Functional Coatings—Recent Advances and Future Challenges

Chitosan PVA and Acalypha indica-based nanoformulation for antimicrobial activity against Staphylococcus aureus

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