Biologically active isoquinoline alkaloids covering 2014–2018

Shang, Xiaofei; Yang, Cheng‐Jie; Morris‐Natschke, Susan L.; Li, Jun‐Cai; Yin, Xiaoyi; Liu, Ying‐Qian; Guo, Xiao; Peng, Jingwen; Goto, Masuo; Zhang, Jiyu; Lee, Kuo‐Hsiung

doi:10.1002/med.21703

Cited by 145 publications

(79 citation statements)

References 350 publications

(979 reference statements)

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“…exhibited cytotoxic effect against three leukemia cells in vitro. In another study, 7epiancistrobrevine and ancistrotectoriline exhibited activity against pancreatic cancer cells (Shang et al, 2020). The present study is the first to report on in vitro selective antiproliferative activity of A. tectorius (Lour.)…”

Section: Discussionsupporting

confidence: 55%

In Vitro Selective Antibacterial and Antiproliferative Effects of Ethanolic Extracts from Cambodian and Philippine Plants Used in Folk Medicine for Diarrhea Treatment

et al. 2021

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Bacterial diarrhea remains a global health problem, especially in developing tropical countries. Moreover, dysbiosis caused by diarrheagenic bacteria and inappropriate antimicrobial treatment has been associated with intestinal carcinogenesis. Despite the rich tradition of the use of herbs for the treatment of gastrointestinal disorders in Cambodian and Philippine folk medicine, many of them have not yet been systematically studied for their in vitro selective inhibitory effects on intestinal bacteria and cells. In the present study, in vitro inhibitory activities of 35 ethanolic extracts derived from 32 Cambodian and Philippine medicinal plants were determined by broth microdilution method against 12 pathogenic bacteria. Furthermore, cytotoxicity against intestinal cancer cells (Caco-2 and HT-29) using thiazolyl blue tetrazolium bromide cytotoxicity assay and safety to six beneficial intestinal bacteria (bifidobacteria and lactobacilli) and intestinal normal cells (FHs 74 Int) were determined for the antimicrobially active extracts. Selectivity indices (SIs) were calculated among the averages of minimum inhibitory concentrations (MICs), half-maximal inhibitory concentrations (IC50), and 80% inhibitory concentrations of proliferation (IC80) for each type of the tested agents. The extracts of Artocarpus blancoi (Elmer) Merr. (Moraceae), Ancistrocladus tectorius (Lour.) Merr. (Ancistrocladaceae), and Pentacme siamensis (Miq.) Kurz (Dipterocarpaceae) produced significant growth-inhibitory effects (MICs = 32–512 μg/ml) against intestinal pathogenic bacteria at the concentrations nontoxic to normal intestinal cells (IC80 values >512 μg/ml; SIs = 0.11–0.2). Moreover, the extract of P. siamensis (Miq.) Kurz was relatively safe to beneficial bacteria (MICs ≥512 μg/ml; SI = 0.1), and together with A. blancoi (Elmer) Merr., they selectively inhibited intestinal cancer cells (IC50 values ≥51.98 ± 19.79 μg/ml; SIs = 0.3 and 0.6). Finally, a strong selective antiproliferative effect on cancer cells (IC50 values 37.89 ± 2.68 to 130.89 ± 13.99 μg/ml; SIs = 0.5) was exerted by Ehretia microphylla Lam. (Boraginaceae), Lagerstroemia cochinchinensis Pierre ex Gagnep. (Lythraceae), and Melastoma saigonense (Kuntze) Merr. (Melastomataceae) (leaves with flower buds). The results suggest that the above-mentioned species are promising materials for the development of new selective antibacterial and antiproliferative agents for the treatment of infectious diarrhea and associated intestinal cancer diseases. However, further research is needed regarding the isolation and identification of their active constituents.

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Section: Discussionsupporting

confidence: 55%

In Vitro Selective Antibacterial and Antiproliferative Effects of Ethanolic Extracts from Cambodian and Philippine Plants Used in Folk Medicine for Diarrhea Treatment

et al. 2021

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“…In one study, researchers stated that rutin has a strong binding pattern to the pocket of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), which may result in the strong inhibition of SARS-CoV-2 RdRp [ 32 , 36 ]. Furthermore, fumariline is an isoquinoline alkaloid [ 37 ] that has a good interaction with the targets M pro and RBD. Additionally, two alkaloids (thalimonine and sophaline D) have demonstrated potential inhibitory activity against M pro [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

In Silico Evaluation of Iranian Medicinal Plant Phytoconstituents as Inhibitors against Main Protease and the Receptor-Binding Domain of SARS-CoV-2

et al. 2021

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The novel coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which initially appeared in Wuhan, China, in December 2019. Elderly individuals and those with comorbid conditions may be more vulnerable to this disease. Consequently, several research laboratories continue to focus on developing drugs to treat this infection because this disease has developed into a global pandemic with an extremely limited number of specific treatments available. Natural herbal remedies have long been used to treat illnesses in a variety of cultures. Modern medicine has achieved success due to the effectiveness of traditional medicines, which are derived from medicinal plants. The objective of this study was to determine whether components of natural origin from Iranian medicinal plants have an antiviral effect that can prevent humans from this coronavirus infection using the most reliable molecular docking method; in our case, we focused on the main protease (Mpro) and a receptor-binding domain (RBD). The results of molecular docking showed that among 169 molecules of natural origin from common Iranian medicinal plants, 20 molecules (chelidimerine, rutin, fumariline, catechin gallate, adlumidine, astragalin, somniferine, etc.) can be proposed as inhibitors against this coronavirus based on the binding free energy and type of interactions between these molecules and the studied proteins. Moreover, a molecular dynamics simulation study revealed that the chelidimerine–Mpro and somniferine–RBD complexes were stable for up to 50 ns below 0.5 nm. Our results provide valuable insights into this mechanism, which sheds light on future structure-based designs of high-potency inhibitors for SARS-CoV-2.

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“…Generally, the higher value of zeta potential means a more stable mixed system. [ 23,24 ] As shown in Figure 4, the zeta potential values of SGP‐1, SGP‐2, SGP‐3 and SGP‐4 were –18.36, –18.96, –20.07 mV, and –23.4 mV, respectively. All values were negative, which illustrated that the purified polysaccharides were anionic polysaccharides.…”

Section: Resultsmentioning

confidence: 99%

Extraction, Purification, Characterization, and Bioactive Properties of Polysaccharides from Sphallerocarpus gracilis

Assani

Wang

et al. 2021

Starch Stärke

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Four new polysaccharides, SGP‐1‐4, are isolated and purified from Sphallerocarpus gracilis (S. gracilis) . The monosaccharide analysis revealed that the isolated polysaccharides are composed of different molar ratios of glucose (Glu), galactose (Gal), rhamnose (Rha), mannose (Man), and arabinose (Ara). Congo red test showed that no triple helical structure is detected in SGP‐1‐4. The Zeta potentials of SGP‐1‐4 are negative. The antioxidant activities are evaluated using DPPH and Superoxide radical assays. In vitro antitumor activities are investigated by MTT assay and Calcein‐AM/PI staining confocal imaging. The hypolipidemic activities are measured by the bile‐salt binding capacity in vitro. The results indicated that SGP‐1‐4 possessed significant antioxidant and hypolipidemic abilities. At the concentration of 0.2 mg/mL, the purified polysaccharides possess no significant effects against MGC‐803 (Human gastric cancer cells), A2780 (Human ovarian cancer cells), T24 (Human bladder cancer cells), CNE‐2 (Human nasopharyngeal cancer cells), and 4T1 (Mouse breast cancer cells) tumor cells in vitro. However, the SGP‐2 shows potential as a DOX‐chemotherapy against 4T1 cells, which indicated that SGP‐2 could exert antitumor effects. These findings provide a scientific basis for the further use of S. gracilis polysaccharides as a natural antioxidant, antitumor, and hypolipidemic agent in industry.

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Biologically active isoquinoline alkaloids covering 2014–2018

Cited by 145 publications

References 350 publications

In Vitro Selective Antibacterial and Antiproliferative Effects of Ethanolic Extracts from Cambodian and Philippine Plants Used in Folk Medicine for Diarrhea Treatment

In Vitro Selective Antibacterial and Antiproliferative Effects of Ethanolic Extracts from Cambodian and Philippine Plants Used in Folk Medicine for Diarrhea Treatment

In Silico Evaluation of Iranian Medicinal Plant Phytoconstituents as Inhibitors against Main Protease and the Receptor-Binding Domain of SARS-CoV-2

Extraction, Purification, Characterization, and Bioactive Properties of Polysaccharides from Sphallerocarpus gracilis

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