Biologically active polymers: VII. Synthesis and antimicrobial activity of some crosslinked copolymers with quaternary ammonium and phosphonium groups

Immobilization Reduces the Activity of Surface-Bound Cationic Antimicrobial Peptides with No Influence upon the Activity Spectrum

“…The most important approaches to the development of such biomedical products include investigations of (i) surfaces with covalently bound antimicrobial agents (11,12,15,16,28,32); (ii) surfaces covered with bacterium-repellent or antiadhesive agents that use highly hydrated and close-packed chain-like molecules, such as PEG (polyethylene glycol) (19), or bearing negative charges (27); (iii) polymer matrices with incorporated antibiotics (noncovalent) which are released into the surrounding medium in a controlled manner (31,49); and finally, (iv) antimicrobial polymers which are synthesized by polymerization of constitutive monomers with therapeutic moieties (13,40,52). However, these strategies suffer from several disadvantages, such as a limited affinity of biomaterials for antibiotics, the likelihood of modification of the mechanical properties of the materials, and the limited available spectrum of therapeutics and active monomers with polymerization-compatible chemistry.…”

Synthesis and characterization of polymeric prodrug conjugate systems based on poly (p-hydroxystyrene): In vitro hydrolysis behavior and antibacterial activity

“…The cultures containing the test organisms and different concentrations of the selected polymer were incubated for 24 h at 37 o C, then optical density of growth was measured by spectrophotometer at 620 nm for each incubated mixture, results were represented graphically, and MIC was recorded for the tested material (Kenawy et al, 2006, Mahmoud et al, 2001). …”

“…Amination of chloroacetylated poly(p-hydroxystyrene) (P1; CPHS) to produce polymer P3 was prepared by reacting P1 with 1,3-diamino propane in dry 1,4-dioxane by similar previously reported procedure (Hazziza-Laskar et al, 1993) (Scheme 3). This polymer was prepared to examine the effect of the new functional groups on the antibacterial activity and compare it with polymer P1 (Kenawy et al, 2006). The elemental analysis confirmed that the nitrogen content of polymer P3 was in good value of content compared to calculated value [N%; Calculated 11.9, Found 9.64] indicating good loading reaction yield.…”

Synthesis and Evaluation of the Antimicrobial Activity of Dodecyl trimethyl ammonium and N-(N, N-dimethylamino) Propyl Glucosylamine

“…Therefore, it is the responsibility of scientists to work hard and to find out environment friendly active compounds which can be used in this struggling. Previous reports indicated that amino sugars and ammonium compounds could be one of the good candidates to reach the goal [18][19][20][21][22][23][24] . This study is our contribution in this scientists' task and was enabled to synthesize two molecules with promised results.…”