Biologically Effective Doses of Postoperative Radiotherapy in the Prevention of Keloids

Abstract

The results of this study indicate that for effectively treating keloids postoperatively, a relatively high dose must be applied in a short overall treatment time. The optimal treatment probably is an irradiation scheme resulting in a BED value of at least 30 Gy. A BED value of 30 Gy can be obtained with, for instance, a single acute dose of 13 Gy, two fractions of 8 Gy or three fractions of 6 Gy, or a single dose of 27 Gy at low dose rate. The radiation treatment should be administered within 2 days after surgery.

Biologically Effective Dose in Total-Body Irradiation and Hematopoietic Stem Cell Transplantation

“…A relatively high BED for leukemic cells can only be applied taking the tolerance BED of normal tissues into account [25,27]. In most of the studies, the lung dose was restricted to a total dose of 8-9 Gy corresponding to a BED value for lung tissue of 12-14 Gy.…”

Estimation of Cancer Risks from Radiotherapy of Benign Diseases

“…The effectiveness of radiotherapy of various nonmalignant diseases has been proven, not only by clinical experience [21,25] but also by the demonstration of a dependence of clinical effect on radiation dose [7,11]. Moreover, the underlying biological mechanisms have carefully been explored recently [17].…”

Dosimetric Results of Postoperative Tomodirect Radiotherapy of Keloid on Ear Cartilage

“…Ogawa et al [11] suggested that postoperative radiation therapy of 10 to 20 Gy delivered as 5 Gy per fraction are safe and efficient means of keloid treatment in adult patients. In a dose-effect analysis, Kal and Veen [10] concluded that recurrence rate was <10% when biologically effective dose values were higher than 30 Gy, and that radiation treatment should be administered within 2 days of surgery. In the present case, radiation therapy was performed with 15 Gy in 3 fractions, 33 hours after excision.…”