Biologically Inspired Collagen/Apatite Composite Biomaterials for Potential Use in Bone Tissue Regeneration—A Review

Kołodziejska, Barbara; Kaflak, Agnieszka; Kolmas, Joanna

doi:10.3390/ma13071748

Cited by 68 publications

(68 citation statements)

References 98 publications

(148 reference statements)

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“…The two major constituents of bone are hydroxyapatite and collagen, which both are usually used in bone reconstruction. Collagen-hydroxyapatite (CHA) scaffolds benefit from combining the mechanical strength of ceramics with the biological advantages of collagen [ 88 ]. Usually, collagen-containing scaffolds with a high level of cross-linking show a higher printability and porosity with proper diffusion of the nutrients for cell activity [ 89 , 90 ].…”

Section: Biomedical Application Of Protein-based 3d Printed Materialsmentioning

confidence: 99%

Protein-Based 3D Biofabrication of Biomaterials

et al. 2021

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Protein/peptide-based hydrogel biomaterial inks with the ability to incorporate various cells and mimic the extracellular matrix’s function are promising candidates for 3D printing and biomaterials engineering. This is because proteins contain multiple functional groups as reactive sites for enzymatic, chemical modification or physical gelation or cross-linking, which is essential for the filament formation and printing processes in general. The primary mechanism in the protein gelation process is the unfolding of its native structure and its aggregation into a gel network. This network is then stabilized through both noncovalent and covalent cross-link. Diverse proteins and polypeptides can be obtained from humans, animals, or plants or can be synthetically engineered. In this review, we describe the major proteins that have been used for 3D printing, highlight their physicochemical properties in relation to 3D printing and their various tissue engineering application are discussed.

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Section: Biomedical Application Of Protein-based 3d Printed Materialsmentioning

confidence: 99%

Protein-Based 3D Biofabrication of Biomaterials

et al. 2021

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“…Furthermore, the roughness that HA nano or microparticles provide to a collagen scaffold will positively affect cell proliferation and differentiation [ 116 ]. More detailed information about collagen-apatite composite biomaterials can be found in the review by Kołodziejska et al [ 117 ]. Other bioceramic components that have been extensively explored to form composites with collagen are β-tricalcium phosphate (β-TCP) and bioglasses, which have all shown to improve the mechanical properties of collagen-based scaffolds and to increase osteoblastic cell differentiation [ 17 ].…”

Section: Composite Materials With Collagen Type Imentioning

confidence: 99%

Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering

et al. 2021

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Collagen type I is the main organic constituent of the bone extracellular matrix and has been used for decades as scaffolding material in bone tissue engineering approaches when autografts are not feasible. Polymeric collagen can be easily isolated from various animal sources and can be processed in a great number of ways to manufacture biomaterials in the form of sponges, particles, or hydrogels, among others, for different applications. Despite its great biocompatibility and osteoconductivity, collagen type I also has some drawbacks, such as its high biodegradability, low mechanical strength, and lack of osteoinductive activity. Therefore, many attempts have been made to improve the collagen type I-based implants for bone tissue engineering. This review aims to summarize the current status of collagen type I as a biomaterial for bone tissue engineering, as well as to highlight some of the main efforts that have been made recently towards designing and producing collagen implants to improve bone regeneration.

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“…Due to their superior biocompatibility and minute negative immunological influence, natural polymers such as chitosan, collagen, gelatin, hyaluronic acid, alginate, and fibroin are extensively used in BTE research. However, they have insufficient mechanical strength, rapid degradation rate, unstable biological properties, and limited production capacity, and therefore, these materials are difficult to design, process, and apply for bone defect repair (Venkatesan et al, 2015;Jahan and Tabrizian, 2016;Melke et al, 2016;Saravanan et al, 2018;Kashirina et al, 2019;Ranganathan et al, 2019;Zhai et al, 2019;Kołodziejska et al, 2020). As a representative, silk fibroin (SF) has shown a good prospect in BTE due to its excellent biocompatibility, high porosity, and good mechanical properties (Mottaghitalab et al, 2015;Saleem et al, 2020).…”

Section: Natural Polymersmentioning

confidence: 99%

Recent Trends in the Development of Bone Regenerative Biomaterials

Tang

Liu

et al. 2021

Front. Cell Dev. Biol.

130

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The goal of a biomaterial is to support the bone tissue regeneration process at the defect site and eventually degrade in situ and get replaced with the newly generated bone tissue. Biomaterials that enhance bone regeneration have a wealth of potential clinical applications from the treatment of non-union fractures to spinal fusion. The use of bone regenerative biomaterials from bioceramics and polymeric components to support bone cell and tissue growth is a longstanding area of interest. Recently, various forms of bone repair materials such as hydrogel, nanofiber scaffolds, and 3D printing composite scaffolds are emerging. Current challenges include the engineering of biomaterials that can match both the mechanical and biological context of bone tissue matrix and support the vascularization of large tissue constructs. Biomaterials with new levels of biofunctionality that attempt to recreate nanoscale topographical, biofactor, and gene delivery cues from the extracellular environment are emerging as interesting candidate bone regenerative biomaterials. This review has been sculptured around a case-by-case basis of current research that is being undertaken in the field of bone regeneration engineering. We will highlight the current progress in the development of physicochemical properties and applications of bone defect repair materials and their perspectives in bone regeneration.

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Biologically Inspired Collagen/Apatite Composite Biomaterials for Potential Use in Bone Tissue Regeneration—A Review

Cited by 68 publications

References 98 publications

Protein-Based 3D Biofabrication of Biomaterials

Protein-Based 3D Biofabrication of Biomaterials

Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering

Recent Trends in the Development of Bone Regenerative Biomaterials

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