Biologically inspired stealth – Camouflaged strategies in nanotechnology for the improved therapies in various diseases

Imran, Muhammad; Gowd, Vemana; Saha, Puspita; Rashid, Summya; Chaudhary, Anis Ahmad; Mohamed, Marwa Y. A.; Alawam, Abdullah S.; Khan, Rehan

doi:10.1016/j.ijpharm.2022.122407

Cited by 6 publications

(4 citation statements)

References 114 publications

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“…The concept of the application of nanotechnology in disease treatment was proposed by Siddiqui and associates [46]. The utilization of nano-delivery systems to achieve cancer targeting has been proven to be an effective approach for obtaining better therapeutic outcomes [47][48][49]. As nanoparticles are able to bypass the natural barriers in the body, they can achieve effective release kinetics, and can easily target the desired locations [50,51].…”

Section: Pharmaceutical Application Of Flavonoids Against Various Can...mentioning

confidence: 99%

Exploring the Remarkable Chemotherapeutic Potential of Polyphenolic Antioxidants in Battling Various Forms of Cancer

et al. 2023

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Plant-derived compounds, specifically antioxidants, have played an important role in scavenging the free radicals present under diseased conditions. The persistent generation of free radicals in the body leads to inflammation and can result in even more severe diseases such as cancer. Notably, the antioxidant potential of various plant-derived compounds prevents and deregulates the formation of radicals by initiating their decomposition. There is a vast literature demonstrating antioxidant compounds’ anti-inflammatory, anti-diabetic, and anti-cancer potential. This review describes the molecular mechanism of various flavonoids, such as quercetin, kaempferol, naringenin, epicatechin, and epicatechin gallate, against different cancers. Additionally, the pharmaceutical application of these flavonoids against different cancers using nanotechnologies such as polymeric, lipid-based nanoparticles (solid–lipid and liquid–lipid), liposomes, and metallic nanocarriers is addressed. Finally, combination therapies in which these flavonoids are employed along with other anti-cancer agents are described, indicating the effective therapies for the management of various malignancies.

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Section: Pharmaceutical Application Of Flavonoids Against Various Can...mentioning

confidence: 99%

Exploring the Remarkable Chemotherapeutic Potential of Polyphenolic Antioxidants in Battling Various Forms of Cancer

et al. 2023

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“…Nanotechnology offers new promising approaches to synthesizing novel compounds with antibacterial and antibiofilm properties, and a wide palette of nanomaterials has been studied to date to thoroughly understand their antimicrobial properties. − Besides their stand-alone use, solutions building on the combined effects of nanomaterials and antibiotics have also been the focus of interest in many studies. − Antibiotic nanoparticle formulations can offer several advantages over conventional administration and delivery methods, including the ability for drug delivery to a specific site such as an intracellular infection. Nanomaterials can also be exploited to facilitate the sustained release of an antibiotic, minimizing dosing regimens. , Furthermore, nanomaterials can mask the entrapped drug, reducing systemic toxicity induced by conventional administration of the free drug.…”

Section: Introductionmentioning

confidence: 99%

“…Nanomaterials can also be exploited to facilitate the sustained release of an antibiotic, minimizing dosing regimens. 9,10 Furthermore, nanomaterials can mask the entrapped drug, 11 reducing systemic toxicity induced by conventional administration of the free drug. Among the various nanomaterials endowed with antimicrobial properties, carbon-based nanomaterials, including carbon nanodots, graphene oxide, carbon onions, carbon nanotubes (CNTs), and others have been demonstrated as being highly effective in killing pathogenic bacteria, based on diverse mechanisms of action.…”

Section: ■ Introductionmentioning

confidence: 99%

Antibacterial Interactions of Ethanol-Dispersed Multiwalled Carbon Nanotubes with Staphylococcus aureus and Pseudomonas aeruginosa

Asaftei,

Lucidi,

Anton

et al. 2024

ACS Omega

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Infectious diseases are acknowledged as one of the leading causes of death worldwide. Statistics show that the annual death toll caused by bacterial infections has reached 14 million, most of which are caused by drug-resistant strains. Bacterial antibiotic resistance is currently regarded as a compelling problem with dire consequences, which motivates the urgent identification of alternative ways of fighting bacteria. Various types of nanomaterials have been reported to date as efficient antibacterial solutions. Among these, carbon-based nanomaterials, such as carbon nanodots, carbon graphene oxide, and carbon nanotubes (CNTs), have been shown to be effective in killing a wide panel of pathogenic bacteria. With this study, we aim to provide additional insights into this topic of research by investigating the antibacterial activity of a specific type of multiwalled CNTs, with diameters from 50 to 150 nm, against two representative opportunistic pathogens, i.e., the Gram-positive bacterium Staphylococcus aureus and the Gramnegative bacterium Pseudomonas aeruginosa, both included among the top antibiotic-resistant pathogens. We also test the synergistic effect of CNTs with different antibiotics commonly used in the treatment of infections caused by S. aureus and/or P. aeruginosa. Additionally, a novel approach for quantitatively analyzing bacterial aggregation in brightfield microscopy images was implemented. This method was utilized to assess the effectiveness of CNTs, either alone or in combination with antibiotics, in dispersing bacterial aggregates. Finally, atomic force microscopy coupled with a newly devised image analysis pipeline was used to examine any potential morphological changes in bacterial cells following exposure to CNTs and antibiotics.

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“…31 Fortunately, the use of the biomimetic cell membrane camou-flage strategy can help nanoparticles cloak the encapsulated contents to evade RES elimination. [32][33][34] Among natural biological carriers, erythrocyte membranes are accessible and frequently used to prepare biomimetic nanomaterials. In particular, the self-recognition protein CD47 on the erythrocyte membrane surface can inhibit erythrocyte phagocytosis by immune cells, which gives nanocarriers a superior half-life in systemic circulation.…”

Section: Introductionmentioning

confidence: 99%

Erythrocyte membrane-camouflaged DNA-functionalized upconversion nanoparticles for tumor-targeted chemotherapy and immunotherapy

Kou

Nie

et al. 2023

Nanoscale

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Biologically inspired stealth – Camouflaged strategies in nanotechnology for the improved therapies in various diseases

Cited by 6 publications

References 114 publications

Exploring the Remarkable Chemotherapeutic Potential of Polyphenolic Antioxidants in Battling Various Forms of Cancer

Exploring the Remarkable Chemotherapeutic Potential of Polyphenolic Antioxidants in Battling Various Forms of Cancer

Antibacterial Interactions of Ethanol-Dispersed Multiwalled Carbon Nanotubes with Staphylococcus aureus and Pseudomonas aeruginosa

Erythrocyte membrane-camouflaged DNA-functionalized upconversion nanoparticles for tumor-targeted chemotherapy and immunotherapy

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