Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids

Cadet, Jean; Loft, Steffen; Oliński, Ryszard; Evans, Mark D.; Białkowski, Karol; Wagner, Jeffrey; Dedon, Peter C.; Möller, Peter; Greenberg, Marc M.; Cooke, Marcus S.

doi:10.3109/10715762.2012.659248

Cited by 123 publications

(84 citation statements)

References 157 publications

(206 reference statements)

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“…Furthermore, the highly reactive species peroxynitrite, formed by the near-diffusion limited reaction between nitric oxide and superoxide anion, may also directly oxidize proteins or nitrate tyrosine residues leading to nitrosative stress. Additionally, the formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), 2′ a marker of DNA oxidation, was demonstrated to induce mutagenic changes aside from interfering with gene expression (19)(20)(21)(22).…”

Section: Study Design and Patientsmentioning

confidence: 99%

Redox Imbalance in Lung Cancer of Patients with Underlying Chronic Respiratory Conditions

Mateu-Jiménez

Sánchez-Font

Rodríguez-Fuster

et al. 2016

Mol Med

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Chronic respiratory diseases such as obstructive pulmonary disease (COPD) and oxidative stress may underlie lung cancer (LC). We hypothesized that the profile of oxidative and antioxidant events may differ in lung tumors and blood compartments of patients with non-small cell LC (NSCLC) with and without COPD. Redox markers (immunoblotting, ELISA, chemiluminescence, 2D electrophoresis and proteomics) were analyzed in blood samples of 17 control subjects and 80 LC patients (59 LC-COPD and 21 LC) and lung specimens (tumor and nontumor) from those undergoing thoracotomy (35 patients: 23 LC-COPD and 12 LC). As smoking history was more prevalent in LC-COPD patients, these were further analyzed post hoc as heavy and moderate smokers (cutoff, 60 pack-years). Malondialdehyde (MDA)-protein adducts and SOD1 levels were higher in tumor and nontumor samples of LC-COPD than in LC. In tumors compared with nontumors, SOD2 protein content was greater, whereas catalase levels were decreased in both LC and LC-COPD patients. Blood superoxide anion levels, protein carbonylation and nitration were greater in LC and LC-COPD patients than in the controls, and in the latter patients compared with the former. Systemic superoxide anion, protein carbonyls and nitrotyrosine above specific cutoff values best identified underlying COPD among all patients. Smoking did not influence the study results. A differential expression profile of oxidative stress markers exists in blood and, to a lesser extent, in the tumors of LC-COPD patients. These findings suggest that systemic oxidative stress and lung antioxidants (potential biomarkers) may predispose patients with chronic respiratory diseases to a higher risk for LC.

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Section: Study Design and Patientsmentioning

confidence: 99%

Redox Imbalance in Lung Cancer of Patients with Underlying Chronic Respiratory Conditions

Mateu-Jiménez

Sánchez-Font

Rodríguez-Fuster

et al. 2016

Mol Med

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“…Since 1 O 2 does not react with 2-deoxyribose, it cannot cut the DNA backbone, and previously reported formation of DNA nicks can be explained by secondary oxidation of 8-oxo-7,8-dihydro-2′-deoxyguanosine by 1 O 2 [77]. Details about reactive species, mechanisms of oxidatively generated DNA modifications, reactivity of products and biological consequences can be found elsewhere [85,86,87]. …”

Section: Photodynamic Targets At the Molecular Levelmentioning

confidence: 99%

Photodynamic Therapy: Current Status and Future Directions

Benov¹

2014

Med Princ Pract

351

299

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Photodynamic therapy (PDT) is a minimally invasive therapeutic modality used for the management of a variety of cancers and benign diseases. The destruction of unwanted cells and tissues in PDT is achieved by the use of visible or near-infrared radiation to activate a light-absorbing compound (a photosensitizer, PS), which, in the presence of molecular oxygen, leads to the production of singlet oxygen and other reactive oxygen species. These cytotoxic species damage and kill target cells. The development of new PSs with properties optimized for PDT applications is crucial for the improvement of the therapeutic outcome. This review outlines the principles of PDT and discusses the relationship between the structure and physicochemical properties of a PS, its cellular uptake and subcellular localization, and its effect on PDT outcome and efficacy.

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“…However, UV and NMR spectroscopic measurements (Culp et al 1989;Cho et al 1990;Kouchakdjian et al 1991;Oda et al 1991) together with theoretical calculations (Aida and Nishimura 1987; Venkatatesmarlu and Leszczynski 1998) indicate that the 6,8-diketo (i.e., 8-oxodGuo) is the predominant form in solution. For this reason, we prefer using the name for the nucleobase (8-oxo-7,8-dihydroguanine, 8-oxoGua) or for the nucleoside (8-oxodGuo) for describing this ubiquitous DNA oxidation product (Cooke et al 2010;Cadet et al 2012d). However, Kasai and Nishimura, who discovered the base lesion in 1983 (Kasai and Nishimura 1983) retain the term of 8-hydroxyguanine (Nishimura 2011).…”

Section: Singlet Oxygenmentioning

confidence: 99%

DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation

Cadet

Wagner

2013

Cold Spring Harbor Perspectives in Biology

718

510

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Emphasis has been placed in this article dedicated to DNA damage on recent aspects of the formation and measurement of oxidatively generated damage in cellular DNA in order to provide a comprehensive and updated survey. This includes single pyrimidine and purine base lesions, intrastrand cross-links, purine 5 0 ,8-cyclonucleosides, DNA-protein adducts and interstrand cross-links formed by the reactions of either the nucleobases or the 2-deoxyribose moiety with the hydroxyl radical, one-electron oxidants, singlet oxygen, and hypochlorous acid. In addition, recent information concerning the mechanisms of formation, individual measurement, and repair-rate assessment of bipyrimidine photoproducts in isolated cells and human skin upon exposure to UVB radiation, UVA photons, or solar simulated light is critically reviewed.I n this article, we emphasize recent developments in the formation of damage to cellular DNA mediated by reactive oxygen species (ROS) and oxidizing agents, including singlet oxygen, the hydroxyl radical ( † OH), one-electron oxidants, hypochlorous acid (HOCl), and ten-eleven translocation (TET) oxygenases involved in epigenetic regulation. These advances have been possible because of the development of sensitive and powerful high-performance liquid chromatography-mass spectrometry (HPLC-MS)/ mass spectrometry (MS) methods allowing one to revise previously reported data obtained using methods such as gas chromatographymass spectrometry (GC-MS), immunoassays, and HPLC with single MS detection (Cadet et al. , 2012a. Considerable progress has also been made in the elucidation of oxidative degradation pathways of isolated DNA and related model compounds (for recent comprehensive reviews, see Gimisis and Cismaş 2006;Neeley and Essigmann 2006;Pratviel and Meunier 2006;von Sonntag 2006;Cadet et al. 2008Cadet et al. , 2010Cadet et al. , 2012bDedon 2008;Burrows 2009;Wagner and Cadet 2010). In addition, there is much complementary information on solar-radiation-induced formation of bipyrimidine photoproducts in the DNA of fibroblasts, keratinocytes, and human skin. In particular, the distribution of UVA and UVB photoproducts has been determined, allowing accurate determination of their rates of repair (Cadet et al.

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Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids

Cited by 123 publications

References 157 publications

Redox Imbalance in Lung Cancer of Patients with Underlying Chronic Respiratory Conditions

Redox Imbalance in Lung Cancer of Patients with Underlying Chronic Respiratory Conditions

Photodynamic Therapy: Current Status and Future Directions

DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation

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