2019
DOI: 10.1016/j.jtbi.2019.05.022
|View full text |Cite
|
Sign up to set email alerts
|

Biologically sound formal model of Hsp70 heat induction

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
2
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(2 citation statements)
references
References 69 publications
0
2
0
Order By: Relevance
“…Upon heat stress, the denaturation of specific thermolabile proteins leads to the dissociation of HSP chaperones from inactive HSF1/HSP complexes. Then, hyperphosphorylation, trimerization, and translocation of HSF1 occur sequentially (Rieger et al, 2005;Reinke et al, 2008;Scheff et al, 2015;Mazaira et al, 2018;Dudziuk et al, 2019;Masser et al, 2020;Guihur et al, 2022), inducing transcriptional activity of HSF1. The active HSF1 transactivators stimulate the production of HSPs by binding the heat shock elements (HSEs) on the promotor.…”
Section: Temperature Sensing and Transductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Upon heat stress, the denaturation of specific thermolabile proteins leads to the dissociation of HSP chaperones from inactive HSF1/HSP complexes. Then, hyperphosphorylation, trimerization, and translocation of HSF1 occur sequentially (Rieger et al, 2005;Reinke et al, 2008;Scheff et al, 2015;Mazaira et al, 2018;Dudziuk et al, 2019;Masser et al, 2020;Guihur et al, 2022), inducing transcriptional activity of HSF1. The active HSF1 transactivators stimulate the production of HSPs by binding the heat shock elements (HSEs) on the promotor.…”
Section: Temperature Sensing and Transductionmentioning
confidence: 99%
“…The active HSF1 transactivators stimulate the production of HSPs by binding the heat shock elements (HSEs) on the promotor. The resulting excessive HSPs in turn engage in the termination of HSF1 activation with the same sequestration strategy (Gomez-Pastor et al, 2018;Dudziuk et al, 2019). Independent of this molecular chaperone displacement theory, HSF1 can also be activated through different mechanisms, such as temperature-induced intrinsic structural response and other inter-molecular interactions (Hentze et al, 2016;Gomez-Pastor et al, 2018;Mazaira et al, 2018).…”
Section: Temperature Sensing and Transductionmentioning
confidence: 99%