Biologics in Dermatology

Abstract

Skin and subcutaneous diseases affect millions of people worldwide, causing significant morbidity. Biologics are becoming increasingly useful for the treatment of many skin diseases, particularly as alternatives for patients who have failed to tolerate or respond to conventional systemic therapies. Biological therapies provide a targeted approach to treatment through interaction with specific components of the underlying immune and inflammatory disease processes. This review article examines the increasing evidence base for biologics in dermatology, including well-established treatments and novel agents.

Use of ustekinumab for severe refractory atopic dermatitis in a young teenager

“…The TNF antagonist etanercept has reportedly demonstrated a sustained clinical response in severe AD. Infliximab showed a similar positive response, but this was not sustained with further treatment …”

Successful treatment of a patient with severe atopic dermatitis and severe asthma by centrifugal therapeutic plasma exchange

“…It is also in National Institute for Health and Care Excellence (NICE) guidance for the treatment of severe persistent allergic asthma 15. Omalizumab is a humanised recombinant monoclonal antibody that binds free and membrane-bound IgE 16. TPE non-selectively removes IgE from plasma as illustrated by our results.…”

Medicamentos Biológicos na Dermatologia: Uma Revisão das Terapias Inovadoras para Doenças de Pele

“…A dermatologia contemporânea tem testemunhado uma revolução terapêutica nos últimos anos, em grande parte devido ao surgimento dos medicamentos biológicos. Estes agentes inovadores, elaborados a partir de organismos vivos ou seus derivados, oferecem uma abordagem de tratamento mais direcionada para doenças de pele crônicas e refratárias que, até recentemente, eram tratadas apenas com terapias sistêmicas ou tópicas tradicionais, muitas vezes com eficácia limitada e efeitos colaterais significativos (Chandler e Bewley, 2013;Yao et al, 2020). A importância dessa nova classe de medicamentos reside na sua capacidade de intervir em alvos específicos do sistema imunológico, permitindo um controle mais preciso da inflamação e proporcionando alívio sintomático prolongado.…”