Biologics, theranostics, and personalized medicine in drug delivery systems

Puccetti, Matteo; Pariano, Marilena; Schoubben, Aurélie; Giovagnoli, Stefano; Ricci, Maurizio

doi:10.1016/j.phrs.2024.107086

Cited by 26 publications

(7 citation statements)

References 181 publications

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“…Enhancing thermal stability of inclusion complexes may also ensure slow release of eugenol 28 . Finally, customizing treatment according to patients’ needs and offering precise therapies, mainly in terms of personalized dosage, is paramount to enhance therapeutic effectiveness based on the differences observed between the gingival and tongue squamous carcinoma cell lines 99 .…”

Section: Discussionmentioning

confidence: 99%

Eugenol as a potential adjuvant therapy for gingival squamous cell carcinoma

Issa,

Loubaki,

Al Amri

et al. 2024

Sci Rep

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Adoption of plant-derived compounds for the management of oral cancer is encouraged by the scientific community due to emerging chemoresistance and conventional treatments adverse effects. Considering that very few studies investigated eugenol clinical relevance for gingival carcinoma, we ought to explore its selectivity and performance according to aggressiveness level. For this purpose, non-oncogenic human oral epithelial cells (GMSM-K) were used together with the Tongue (SCC-9) and Gingival (Ca9-22) squamous cell carcinoma lines to assess key tumorigenesis processes. Overall, eugenol inhibited cell proliferation and colony formation while inducing cytotoxicity in cancer cells as compared to normal counterparts. The recorded effect was greater in gingival carcinoma and appears to be mediated through apoptosis induction and promotion of p21/p27/cyclin D1 modulation and subsequent Ca9-22 cell cycle arrest at the G0/G1 phase, in a p53-independent manner. At these levels, distinct genetic profiles were uncovered for both cell lines by QPCR array. Moreover, it seems that our active component limited Ca9-22 and SCC-9 cell migration respectively through MMP1/3 downregulation and stimulation of inactive MMPs complex formation. Finally, Ca9-22 behaviour appears to be mainly modulated by the P38/STAT5/NFkB pathways. In summary, we can disclose that eugenol is cancer selective and that its mediated anti-cancer mechanisms vary according to the cell line with gingival squamous cell carcinoma being more sensitive to this phytotherapy agent.

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Section: Discussionmentioning

confidence: 99%

Eugenol as a potential adjuvant therapy for gingival squamous cell carcinoma

Issa,

Loubaki,

Al Amri

et al. 2024

Sci Rep

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“…115–117 This development of in vitro cancer models capable of emulating drug responses unique to each patient is a major focus in personalized medicine. 118 Despite this, the current technologies used in crafting such models primarily reproduce only the morphological diversity found in human cancer tissues. 119 The creation of patient-specific cancer models is vital for effectively simulating personalized drug reactions.…”

Section: Application Of Printable Biomaterials For Cancer Therapymentioning

confidence: 99%

Application of 3D, 4D, 5D, and 6D bioprinting in cancer research: what does the future look like?

Khorsandi,

Rezayat,

Sezen

et al. 2024

J. Mater. Chem. B

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“…The effect of L. casei postbiotics (LCP) at a sub-minimum inhibitory concentration on the expression of QS genes, including lasR/I, rhlR/I, pqsA, pqsR, and virulence genes including pelF (pellicle/biofilm glycosyltransferase PelF), lasB (elastase LasB), and toxA (exotoxin A) reducing the virulence and biofilm development of P. aeruginosa , suggested a novel safe natural source for the expansion of anti-virulence treatments [ 196 ].…”

Section: The Main Categories Of Commonly Used Nanopharmaceuticalsmentioning

confidence: 99%

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Petrovic,

Bita,

Barbinta-Patrascu

2024

IJMS

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This study provides a brief discussion of the major nanopharmaceuticals formulations as well as the impact of nanotechnology on the future of pharmaceuticals. Effective and eco-friendly strategies of biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) are outlined. This paper discusses the need to use natural resources for the “green” design of new nanoformulations with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, and the preparation of nanomaterials must be carefully considered. Therefore, safety and long-term effects of pharmaceutical nanoformulations must not be overlooked. The testing of nanopharmaceuticals represents an essential point in their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent a valuable, bioinspired model for nanopharmaceutical testing that avoids using animals. Nanoformulations are critical in various fields, especially in pharmacy, medicine, agriculture, and material science, due to their unique properties and advantages over conventional formulations that allows improved solubility, bioavailability, targeted drug delivery, controlled release, and reduced toxicity. Nanopharmaceuticals have transitioned from experimental stages to being a vital component of clinical practice, significantly improving outcomes in medical fields for cancer treatment, infectious diseases, neurological disorders, personalized medicine, and advanced diagnostics. Here are the key points highlighting their importance. The significant challenges, opportunities, and future directions are mentioned in the final section.

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Biologics, theranostics, and personalized medicine in drug delivery systems

Cited by 26 publications

References 181 publications

Eugenol as a potential adjuvant therapy for gingival squamous cell carcinoma

Eugenol as a potential adjuvant therapy for gingival squamous cell carcinoma

Application of 3D, 4D, 5D, and 6D bioprinting in cancer research: what does the future look like?

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

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