Biologie und Physiologie der Zelle

Berkaloff, André; Bourguet, Jaques; Favard, Pierre; Guinnebault, M

doi:10.1007/978-3-663-19707-2

Cited by 6 publications

(6 citation statements)

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“…The compounds such as flavonoids, sterols, alkaloids, saponins, triterpens, tanins, polyphenols and anthraquinons were present in MCM As and MCM Nl except alkaloids in this later. These substances act specifically on the cell membrane of eggs and proteins (collagens) of larval cuticule, changing their permeability and reducing the cholesterol level in the egg membrane [14, 15, 18, 19]. This process favours the passage of secondary metabolites inside the cell where they interfere with the mechanism of cellular mitosis by inhibiting the segmentation of blastomers in the case of fresh eggs and paralyzing the larva present in eggs in the case of embryonated eggs [20].…”

Section: Discussionmentioning

confidence: 99%

Anthelminthic properties of Methylene chloride-methanol (1:1) extracts of two Cameroonians medicinal plants on Heligmosomoides bakeri (Nematoda: Heligmosomatidea)

Teufack

Tayo

Alidou

et al. 2017

BMC Complement Altern Med

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BackgroundThe resistance of some medico-veterinary parasite strains as well as the unavailability and toxicity of synthetic anthelminthics on humans, animals and the impacts of their residues in the environment have pushed scientists to turn to plants with anthelminthic properties. Hence, the aim of this work was to contribute to the fight against helminths of medical and veterinary importance in general, and also to clear the environment of their free living stages.MethodsFresh eggs of Heligmosomoides bakeri were obtained from the faeces of experimentally infected mice. L1 and L2 larval stages were obtained after 48 and 72 h of coproculture respectively. Methylene Chloride-Methanol (1:1) extracts of Annona senegalensis and Nauclea latifolia were diluted in DMSO or Tween 80 to prepare the following concentrations: 625, 1250, 2500, 3750 and 5000 μg/ml. The effects of extract solutions were evaluated on the embryonation of eggs, egg hatching and on L1 and L2 survival after 48, 10 and 24 h of incubation. Negative controls were 1.5% DMSO, 4% Tween 80 and a mixture of these solvents. The TLC was carried out and the profiles of secondary metabolites were made.ResultsNegative controls had no effect on the embryonation, eggs hatching and on larval mortality. However, it was found that, the extracts affected the free living stages of H. bakeri in a concentration-dependant manner. At the highest concentration (5000 μg/ml), the rate of inhibition of embryonation obtained were 20.80%, 38.15% and 84.83% for Methylene Chloride-Methanol of Annona senegalensis (MCM As), Nauclea latifolia (MCM Nl) extracts and mixture of Annona senegalensis and Nauclea latifolia (MCM As-Nl) extract respectively. For egg hatch, the inhibition rate was 16.10%, 46.24% and 87.07% for the above three extracts respectively at the same concentration of 5000 μg/ml. On L1 and L2 larval stages after 24 h of exposure to extracts, the mortality rates of 100%, 54.76% and 96.77% against 98%, 51.44% and 100% were obtained for MCM As, MCM Nl and MCM As-Nl respectively at the highest concentration. The Methylene Chloride-Methanol of A.senegalensis, N. latifolia extracts showed the presence of alkaloids except in N. latifolia extract, flavonoids, sterols, triterpens, tanins, polyphenols, anthraquinons, saponins and terpenoids.ConclusionThese findings suggest that, the mixture of the two plant extracts showed an additive (synergetic effect) ovicidal effect and a slight larval mortality on L1 as compared to the effect of MCM As extract alone. These effects were due to the presence ao secondary metabolites identifies in the plant extracts. Thus, they may be used as possible «disinfectants» for soil transmitted nematodes.

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Section: Discussionmentioning

confidence: 99%

Anthelminthic properties of Methylene chloride-methanol (1:1) extracts of two Cameroonians medicinal plants on Heligmosomoides bakeri (Nematoda: Heligmosomatidea)

Teufack

Tayo

Alidou

et al. 2017

BMC Complement Altern Med

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“…(2) The location of the drugs in the bilayer is not incompatible with an intracellular target. Indeed, the membrane components continuously bear synthesis and degradation pathways 25 working respectively from (to) the intracellular compartiments to (from) the membrane bilayer. Hydrophobic drugs can thus be transferred into the intracellular medium when associated with phospholipids.…”

Section: Resultsmentioning

confidence: 99%

Synthetic Pyridopurines Derived from Food Pyrolysis Products: Intercalation, Interactions with Membranes, Cyclodextrin Complexation, and Biological Mitogenic Properties

Debouzy¹,

Gueiffier

Fauvelle³

et al. 1996

Journal of Pharmaceutical Sciences

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Crucial conditions for the pharmacological use of active compounds are their ability to cross the biological barriers and reach their intracellular target. In the case of two antiviral pyridopurine derivatives, 1 and 2, this included essentially the membranes and the nucleic acids. Thus the interactions of 1 and 2 with model membranes and oligonucleotides were studied using NMR spectroscopy. It was found that these hydrophobic molecules can be incorporated into the model membranes at the terminal methyl group level, inducing dynamic perturbations in the bilayer. In the presence of the synthetic oligonucleotide ACATGT, both molecules can intercalate aspecifically in AT and GC systems. Inclusion complexes of 1 and 2 beta-cyclodextrins with a 1:1 stoichiometry, were also prepared. This led to to propose two galenic forms 1 and 2, i.e. included in phospholipid vesicles in the form of a beta-cyclodextrin complex

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“…If their principle function were photo-protective, then their existence in a particular plant or phytoplankton would be confined to those particular UV wavelengths that cause damage to the photosynthetic apparatus, and not to the whole UV broadband spectrum. It is particularly notable that the total absorption spectrum of red algae, for example, has little correspondence to its photosynthetic activation spectrum (Berkaloff et al, 1971).…”

Section: Evidence For Evolutionary Increases In the Hydrological Cyclementioning

confidence: 99%

HESS Opinions "Biological catalysis of the hydrological cycle: life's thermodynamic function"

Michaelian

2012

Hydrol. Earth Syst. Sci.

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Abstract. Darwinian theory depicts life as being overwhelmingly consumed by a fight for survival in a hostile environment. However, from a thermodynamic perspective, life is a dynamic, out of equilibrium process, stabilizing and coevolving in concert with its abiotic environment. The living components of the biosphere on the Earth's surface of greatest biomass, the plants and cyanobacteria, are involved in the transpiration of a vast amount of water. Transpiration is part of the global water cycle, and it is this cycle that distinguishes Earth from its apparently life-barren neighboring planets, Venus and Mars. The dissipation of sunlight into heat by organic molecules in the biosphere, and its coupling to the water cycle (as well as other abiotic processes), is by far the greatest entropy-producing process occurring on Earth. Life, from this perspective, can be viewed as performing an important thermodynamic function, acting as a dynamic catalyst by aiding irreversible abiotic processes such as the water cycle, hurricanes, and ocean and wind currents to produce entropy. The role of animals in this view is that of unwitting but dedicated servants of the plants and cyanobacteria, helping them to grow, and to spread into initially inhospitable areas.

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Biologie und Physiologie der Zelle

Cited by 6 publications

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Anthelminthic properties of Methylene chloride-methanol (1:1) extracts of two Cameroonians medicinal plants on Heligmosomoides bakeri (Nematoda: Heligmosomatidea)

Anthelminthic properties of Methylene chloride-methanol (1:1) extracts of two Cameroonians medicinal plants on Heligmosomoides bakeri (Nematoda: Heligmosomatidea)

Synthetic Pyridopurines Derived from Food Pyrolysis Products: Intercalation, Interactions with Membranes, Cyclodextrin Complexation, and Biological Mitogenic Properties

HESS Opinions "Biological catalysis of the hydrological cycle: life's thermodynamic function"

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Biologie und Physiologie der Zelle

Cited by 6 publications

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Anthelminthic properties of Methylene chloride-methanol (1:1) extracts of two Cameroonians medicinal plants on Heligmosomoides bakeri (Nematoda: Heligmosomatidea)

Anthelminthic properties of Methylene chloride-methanol (1:1) extracts of two Cameroonians medicinal plants on Heligmosomoides bakeri (Nematoda: Heligmosomatidea)

Synthetic Pyridopurines Derived from Food Pyrolysis Products: Intercalation, Interactions with Membranes, Cyclodextrin Complexation, and Biological Mitogenic Properties

HESS Opinions &quot;Biological catalysis of the hydrological cycle: life's thermodynamic function&quot;

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HESS Opinions "Biological catalysis of the hydrological cycle: life's thermodynamic function"