Biology and Diseases of Dogs

Nemzek, Jean A.; Lester, Patrick A.; Wolfe, Amber; Dysko, Robert C.; Myers, Daniel D.

doi:10.1016/b978-0-12-409527-4.00012-2

Cited by 11 publications

(10 citation statements)

References 130 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our hematology analysis showed that the ND-IV-M, NDX-IV-M, NDX-IV-F, and NDX-HPV-M did not cause dramatic changes to white blood cells (WBC), platelet count (PLT), neutrophils (NEUT), and lymphocytes (LYM) (Fig. 4), and reference ranges were according to previous studies [43]. Meanwhile, ND or NDX did not cause subacute inflammation.…”

Section: Hematology Analysissupporting

confidence: 67%

Safety evaluation of nanodiamond-doxorubicin complexes in a Naïve Beagle canine model using hematologic, histological, and urine analysis

Wang

Ahmad

et al. 2021

Nano Res.

View full text Add to dashboard Cite

While doxorubicin (DOX) is one of the most common chemotherapeutic drugs for treating cancer, use of DOX must be managed carefully due to dose-related toxicity. Nanodiamond (ND) drug delivery system conjugated with DOX (NDX) has been reported to enhance treatment efficacy and attenuate toxicity in murine cancer models. In addition, extensive biocompatibility studies indicate that NDs seem to be well tolerated in non-human primates. Before the clinical translation of NDX, it is necessary to verify the safety of ND in large mammals. Studies of nanomedicine drug safety for large animal are not commonly reported, and this work represents a key milestone in bridging earlier advances towards clinical assessment. Herein, NDs' safety as a drug-delivery platform was evaluated in Naïve Beagle dogs. The study is performed with DOX, ND, and NDX in a dual-gender animal model using intravenous (IV) injection and hepatic portal vein (HPV) injection methods. The dogs are monitored for their health phenotype changes in continuous 5 days. Blood and urine obtained are for clinical pathology research. The results indicate that ND drug delivery platform significantly relieves DOX toxicity for Naïve Beagle dog model. This study provides guidance for the pre-clinical safety assessment of NDX therapy at large animal level.

show abstract

Section: Hematology Analysissupporting

confidence: 67%

Safety evaluation of nanodiamond-doxorubicin complexes in a Naïve Beagle canine model using hematologic, histological, and urine analysis

Wang

Ahmad

et al. 2021

Nano Res.

View full text Add to dashboard Cite

show abstract

“…Cacing dewasa berpredileksi di usus halus dan dalam jumlah besar akan menyebabkan gangguan. Infeksi berat pada hewan muda umumnya muncul gejala klinis yang tidak spesifik seperti konstipasi dan diare (Nemzek et al, 2015). Manusia juga bisa terinfeksi D. caninum dan menimbulkan gejala klinis berupa sakit perut, mual, dan muntah (Jayalakshmi et al, 2017…”

Section: Hasil Dan Pembahasanunclassified

Laporan Kasus: Penanganan Dipylidiasis pada Kucing Anggora dengan Praziquantel

Cahyani

Suartha

Dharmawan

2020

J. Sains Tek. Peter.

View full text Add to dashboard Cite

Dipylidiasis is a tapeworm disease that attacks cats and dogs and classified as a zoonotic disease because it can be transmitted to humans. A 2 years old female angora cat weighing 3 kg was examined with complaints of bloody diarrhea for 2 weeks. The results of native faecal examination showed the presence of D. caninum worm eggs. Animals diagnosed with dipylidiasis. Cat cases were treated by administering 50 mg praziquantel therapy with the recommendation of 1 tablet for 10 kg/BW orally. In conclusion, the treatment of dipylidiasis by administering praziquantel therapy has proven to be effective.

show abstract

“…However, at 12 weeks, MHC expression increased remarkably, further stimulated by lymphocytes, resulting in tumor regression (Foster, 2016). In previous studies, spontaneous regression due to the immune response (immunoglobulin G formation, lymphocyte-mediated cytotoxicity) has been documented at the tumor age of 2 to 9 months (Das & Das, 2000;Foster, 2017a;Nemzek et al, 2015;Thamm, 2007;Ujvari et al, 2017).…”

Section: Introductionmentioning

confidence: 97%

“…The canine transmissible venereal tumor (CTVT) is also known as sticker 's sarcoma, transvenereal sarcoma, infectious sarcoma, canine condyloma, transmissible lymphosarcoma, venereal granuloma, and contagious venereal tumor (Das & Das, 2000;Nemzek et al, 2015;Thamm, 2007). Despite immense mutation, CTVT adapted, survived, and spread across multiple continents, making it the oldest known continuously passaged somatic cell line (Nemzek et al, 2015). CTVTs are distributed globally, predominantly in tropical and subtropical regions.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Radiographic, Computed Tomographic, and Cellular Phenotypic Features of Primary Nasal Transmissible Venereal Tumors in Four Dogs

Aslam¹,

Lau²,

Rani³

et al. 2022

JTAS

View full text Add to dashboard Cite

The primary nasal canine transmissible venereal tumor (CTVT) is a rare disease that develops by the allografted transmission of neoplastic cells in the nasal cavity. The disease is uncommonly reported in free-roaming dogs, with the social behavior of excessive licking and vigorously sniffing the affected parts of the other dogs in an endemic population. Post-chemotherapeutic computed tomography (CT) scan features and correlation of vincristine sulfate with cellular phenotypes have been scarcely reported in previously available primary nasal CTVT studies. This study describes the radiographic, computed tomographic, and cellular phenotypic features in four dogs affected with stage-4 intranasal CTVTs. The post-chemotherapeutic features of the nasal cavity in fully recovered cases are also highlighted. All data were analyzed retrospectively. All four dogs had stage 4 modified Adam’s staging for nasal tumors due to the complete or partial lysis of the cribriform plate and lymphocytoid plasmacytoid (mixed) phenotype of the neoplastic cells based on the cellularity of cytological samples. All four dogs responded well to five cycles of vincristine sulfate and recovered completely. Two out of four dogs have follow-up scanning after chemotherapy. Based on the present study results, vincristine sulfate is still an effective monotherapy to achieve full recovery, although the number of cycles can vary, possibly depending on the expressed phenotype. Permanent loss of nasal turbinates is the sequelae of therapeutic chemotherapy. Prognosis is not correlated to the staging system but seems good with vincristine sulfate in mixed phenotype cases.

show abstract

Biology and Diseases of Dogs

Cited by 11 publications

References 130 publications

Safety evaluation of nanodiamond-doxorubicin complexes in a Naïve Beagle canine model using hematologic, histological, and urine analysis

Safety evaluation of nanodiamond-doxorubicin complexes in a Naïve Beagle canine model using hematologic, histological, and urine analysis

Laporan Kasus: Penanganan Dipylidiasis pada Kucing Anggora dengan Praziquantel

Radiographic, Computed Tomographic, and Cellular Phenotypic Features of Primary Nasal Transmissible Venereal Tumors in Four Dogs

Contact Info

Product

Resources

About