Biology and Diseases of Ferrets

Marini, Robert P.; Otto, G; Erdman, Susan E.; Palley, Lori S.; Fox, James G.

doi:10.1016/b978-012263951-7/50016-8

Cited by 16 publications

(29 citation statements)

References 87 publications

(103 reference statements)

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“…The 2 mockvaccinated ferrets that showed high neutralizing titers 3 weeks after infection (41219 and 50409) also had high virus titers at day 14. One mock-vaccinated ferret (41247) cleared the virus Table 2 [19]. ALP, alkaline phosphatase; ALT, alanine aminotransferase; ND, not done.…”

Section: Mild Protection Of Ferrets From Sars-cov Conferred By Inactimentioning

confidence: 99%

Severe Acute Respiratory Syndrome Coronavirus Infection in Vaccinated Ferrets

et al. 2007

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Background. Development of vaccines to prevent severe acute respiratory syndrome (SARS) is limited by the lack of well-characterized animal models. Previous vaccine reports have noted robust neutralizing antibody and inflammatory responses in ferrets, resulting in enhanced hepatitis.Methods. We evaluated the humoral immune response and pathological end points in ferrets challenged with the Urbani strain of SARS-associated coronavirus (SARS-CoV) after having received formalin-inactivated wholevirus vaccine or mock vaccine.Results. Humoral responses were observed in ferrets that received an inactivated virus vaccine. Histopathological findings in lungs showed that infection of ferrets produced residual lung lesions not seen in both mock and vaccinated ferrets. SARS-CoV infection demonstrated bronchial and bronchiolar hyperplasia and perivascular cuffing in ferret lung tissue, as seen previously in infected mice. No evidence of enhanced disease was observed in any of the ferrets. All of the ferrets cleared the virus by day 14, 1 week earlier if vaccinated.Conclusions. The vaccine provided mild immune protection to the ferrets after challenge; however, there was no evidence of enhanced liver or lung disease induced by the inactivated whole-virus vaccine. The ferret may provide another useful model for evaluating SARS vaccine safety and efficacy.

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Section: Mild Protection Of Ferrets From Sars-cov Conferred By Inactimentioning

confidence: 99%

Severe Acute Respiratory Syndrome Coronavirus Infection in Vaccinated Ferrets

et al. 2007

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“…[21][22][23][24][25][26] Most values are similar to values reported for other domestic carnivores; however, the hematocrit, hemoglobin, and total erythrocyte and reticulocyte counts in ferrets are generally higher than in the dog or cat. 27 Additionally, ferrets have no detectable blood groups and therefore no naturally occurring antibodies against unmatched erythrocyte antigens. Therefore, repeated transfusions without the development of antibodies are possible in the ferret.…”

Section: Morphology and Numbers Of Peripheral Blood Cellsmentioning

confidence: 99%

“…19,[27][28][29] The hematocrit of ferrets ranges between 30% and 61%, but usually averages between 40% and 50% for adult ferrets and between 32% and 39% for juvenile ferrets. The mean percentage of reticulocytes is reported to be 4% (range of 1%-12%) in male ferrets and 5.3% (range of 2%-14%) in female ferrets.…”

Section: Morphology and Numbers Of Peripheral Blood Cellsmentioning

confidence: 99%

Hematology of the Domestic Ferret (Mustela putorius furo)

Smith

Zimmerman

Moore

2015

Veterinary Clinics of North America: Exotic Animal Practice

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Pet ferrets are presented to veterinary clinics for routine care and treatment of clinical diseases and female reproductive problems. In addition to obtaining clinical history, additional diagnostic testing may be required, including hematological assessments. This article describes common blood collection methods, including venipuncture sites, volume of blood that can be safely collected, and handling of the blood. Hematological parameters for normal ferrets are provided along with a description of the morphology of ferret leukocytes to assist in performing a differential count.

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“…Ferrets with ringworm therefore present a zoonotic risk, and care should be exercised by personnel who handle infected animals [64]. Ferrets with ringworm therefore present a zoonotic risk, and care should be exercised by personnel who handle infected animals [64].…”

Section: Epizootiology and Controlmentioning

confidence: 99%