Biology and Diseases of Rabbits

Suckow, Mark A.; Brammer, David W.; Rush, Howard G.; Chrisp, Clarence E.

doi:10.1016/b978-012263951-7/50012-0

Cited by 37 publications

(30 citation statements)

References 152 publications

(128 reference statements)

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“…The classification of mature and aged is derived from normative rabbit data meeting accepted criteria for aging [16]. All experiments were approved by the Beth Israel Deaconess Medical Center Animal Care and Use Committee and the Harvard Medical Area Standing Committee on Animals and conformed to the Guidelines Regulating the Care and Use of Laboratory Animals (NIH publication no.…”

Section: Animalsmentioning

confidence: 99%

Age- and Gender-Related Differences in Mitochondrial Oxygen Consumption and Calcium With Cardioplegia and Diazoxide

McCully

Rousou

Parker

et al. 2007

The Annals of Thoracic Surgery

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Background-We have recently shown that the cardioprotection afforded by cardioplegia is affected by age and gender and is less effective in the aged female rabbit heart compared with the aged male rabbit heart. We hypothesized that these differences were due to age and gender-specific modulation of mitochondrial oxygen consumption and mitochondrial free matrix calcium ([Ca 2+ ] Mito ) content occurring during early reperfusion.

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Section: Animalsmentioning

confidence: 99%

Age- and Gender-Related Differences in Mitochondrial Oxygen Consumption and Calcium With Cardioplegia and Diazoxide

McCully

Rousou

Parker

et al. 2007

The Annals of Thoracic Surgery

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“…5 Furthermore, CRPV infection has served as a standard in vivo preclinical model for the development of high-risk-type Human papillomavirus (HPV)-induced malignancy in humans. 3,5,12,25 However, there is difficulty in studying the naturally occurring disease in the laboratory as there are limited commercial supplies available of Sylvilagus spp., and this species does not generally adapt well to captivity. 11 Microscopic examination of affected areas revealed multiple papillary masses lined by stratified squamous epithelial cells with central cores of fibrovascular connective tissue arising from the epidermis as well as parakeratotic hyperkeratosis.…”

Section: <!?Show "Fnote_aff1"$^!"content-markup(/author-grp[1]/aff|/author-grp[1]/dept-list)>mentioning

confidence: 99%

“…experimentally or naturally via arthropods that feed on the lesions. 22,25 Lesions may regress via immune-mediated processes or may develop into carcinomas. 5,21,22 Notably, a high proportion of these tumors in Oryctolagus spp.…”

Section: <!?Show "Fnote_aff1"$^!"content-markup(/author-grp[1]/aff|/author-grp[1]/dept-list)>mentioning

confidence: 99%

Cottontail Rabbit Papillomavirusin Langerhans Cells inSylvilagusspp.

Weiner¹,

Rosenbaum

Fox³

et al. 2010

J VET Diagn Invest

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Abstract. A wildlife sanctuary presented an adult female cottontail rabbit (Sylvilagus spp.), age unknown, to the Colorado State University Pathology service for postmortem examination. Gross examination revealed numerous pigmented wartlike lesions arising from the skin of the head surrounding the ears, eyes, nares, mouth, and dorsum. Masses were firm, friable, and easily detached from the underlying skin. Differential diagnoses included Cottontail rabbit papillomavirus, Rabbit fibroma virus, and Myxoma virus. Histological examination revealed multiple papillary masses lined by stratified squamous epithelial cells with central cores of fibrovascular connective tissue and parakeratotic hyperkeratosis. Cells of the Stratum spinosum were frequently swollen with abundant perinuclear, cytoplasmic, clearing, and occasional intranuclear basophilic, glassy, spherical inclusions up to 3 mm in diameter. The lesions were consistent with Cottontail rabbit papillomavirus infection. Papilloma virus antigens were identified by immunohistochemistry. In addition, papillomavirus particles were identified by transmission electron microscopy within Langerhans cells of the epidermis, suggesting a unique mechanism for systemic dissemination of the virus. The present case report highlights the finding of viral particles within the Langerhans cells and suggests a novel mechanism of pathogenesis.

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“…These two outbreaks may have had a common origin. The mode of transmission and natural host of this virus (and the Alaskan virus mentioned below) are unknown, and Suckow et al (2002) write that the 'virus has not been well documented'. The properties of this virus differ from the two herpesviruses previously described in lagomorphs (Onderka et al 1992;Hudson 1994).…”

Section: Viruses Herpesvirusesmentioning

confidence: 99%

“…The main pathogens known to affect captive European rabbits are summarised in Weisbroth et al (1974), Baker (1998), Wilber (1999), Fenner and Fantini (1999), Suckow et al (2002) and Percy and Barthold (2007). The suitability for introduction of these agents is difficult to assess accurately on the basis of published information, and further work will be required for more reliable assessments.…”

Section: Agents Present Overseas In European Rabbitsmentioning

confidence: 99%

The future biological control of pest populations of European rabbits, Oryctolagus cuniculus

2008

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Abstract. European rabbits are exotic pests in Australia, New Zealand, parts of South America and Europe, and on many islands. Their abundance, and the damage they cause, might be reduced by the release of naturally occurring or genetically modified organisms (GMOs) that act as biological control agents (BCAs). Some promising pathogens and parasites of European rabbits and other lagomorphs are discussed, with special reference to those absent from Australia as an example of the range of necessary considerations in any given case. The possibility of introducing these already-known BCAs into areas where rabbits are pests warrants further investigation. The most cost-effective method for finding potentially useful but as-yet undiscovered BCAs would be to maintain a global watch on new diseases and pathologies in domestic rabbits. The absence of wild European rabbits from climatically suitable parts of North and South America and southern Africa may indicate the presence there of useful BCAs, although other explanations for their absence are possible. Until the non-target risks of deploying disseminating GMOs to control rabbits have been satisfactorily minimised, efforts to introduce BCAs into exotic rabbit populations should focus on naturally occurring organisms. The development of safe disseminating GMOs remains an important long-term goal, with the possible use of homing endonuclease genes warranting further investigation.

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Biology and Diseases of Rabbits

Cited by 37 publications

References 152 publications

Age- and Gender-Related Differences in Mitochondrial Oxygen Consumption and Calcium With Cardioplegia and Diazoxide

Age- and Gender-Related Differences in Mitochondrial Oxygen Consumption and Calcium With Cardioplegia and Diazoxide

Cottontail Rabbit Papillomavirusin Langerhans Cells inSylvilagusspp.

The future biological control of pest populations of European rabbits, Oryctolagus cuniculus

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