Biology and signal transduction pathways of the Lymphotoxin-αβ/LTβR system

Remouchamps, Caroline; Boutaffala, Layla; Ganeff, Corinne; Dejardin, Emmanuel

doi:10.1016/j.cytogfr.2011.11.007

Cited by 61 publications

(56 citation statements)

References 115 publications

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“…The latter is triggered by either binding of LTα1β2 heterotrimers expressed by activated T, B, natural killer (NK) cells and lymphoid tissue inducer cells, or LIGHT (homologous to l ymphotoxin exhibits i nducible expression and competes with HSV g lycoprotein D for binding to h erpes virus entry mediator, a receptor expressed on T lymphocytes), a TNFSF member expressed on T lymphocytes 9–11. Under pathological conditions, LTs and LIGHT can also be expressed by epithelial cells 12 13. LTβR is mainly expressed on epithelial and stromal cells, thereby enabling the communication with lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

Lymphotoxin β receptor signalling executesHelicobacter pylori-driven gastric inflammation in a T4SS-dependent manner

Mejías-Luque

Zöller

Anderl

et al. 2016

Gut

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Section: Introductionmentioning

confidence: 99%

Lymphotoxin β receptor signalling executesHelicobacter pylori-driven gastric inflammation in a T4SS-dependent manner

Mejías-Luque

Zöller

Anderl

et al. 2016

Gut

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“…This triggers the activation of the inhibitor of ĸB (IĸB) kinase (IKK) complex (consisting of IKKα, IKKβ, and NEMO/IKKβ) by ubiquitination of the regulatory subunit NEMO leading to phosphorylation of IKKβ. IKKβ then in turn leads to the phosphorylation and proteasomal degradation of IĸBa, hence allowing nuclear translocation of the p50/RelA (NF-ĸB1) heterodimer mediating proinflammatory and prosurvival signaling [33]. …”

Section: Physiologymentioning

confidence: 99%

Lymphotoxin, NF-ĸB, and Cancer: The Dark Side of Cytokines

Bauer

Namineni²,

Reisinger³

et al. 2012

Dig Dis

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Cytokines have been implicated in a variety of physiological processes involving lymphoid tissue development, lymphocyte activation, and control of regenerative processes such as wound healing. The first characterization of a cytokine implicated in abolishing or killing tumor cells – the tumor necrosis factor (TNF) – fostered and boosted a completely new field of research that in addition to cancer research started to generate an overwhelming amount of knowledge in immunology, various pathological processes, and other fields of research. Due to the complex networks and versatile functions of cytokines, it soon became clear that cytokines can possess diametric functions in various biological processes. As for tumor research it was shown that some cytokines – depending on the type of organ, the time of action, gender, and the cellular environment – can have either pro- or anticarcinogenic action. For those cytokines reported to be procarcinogenic, this could be accomplished by directly acting as oncogenes or generating an inflammatory environment that is procarcinogenic. Here we review a novel role for TNF family members – in particular lymphotoxin (LT) α and β – in physiology and in driving tumorigenesis, with special focus on the liver. We believe that recent findings on this particular cytokine might have strong implications for the therapy of liver cancer or other inflammation-induced cancer types.

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“…Most of these cytokines are involved in the regulation of several steps of the biological processes related to inflammatory and immune responses. 84,85 Extensive preclinical and clinical investigations have shown that TNF has a pivotal role in the pathogenesis and pathophysiology of IMDs, which has been confirmed by the efficacy of anti-TNF biotechnological drugs, such as etanercept, infliximab and adalimumab, in the therapeutic management of these disorders. 2,86 Overexpression of TNF has been shown to promote proinflammatory processes.…”

Section: Th17 Pathwaymentioning

confidence: 96%

The genomic landscape of human immune-mediated diseases

Chen

2015

J Hum Genet

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As the methodology of genetic detection has developed rapidly in recent years, through techniques such as genome-wide association studies (GWAS) and the secondary generation of sequencing, we are able to view the genomic landscape more clearly. It is well known that genes have a vital role in the pathogenesis of immune-mediated diseases (IMDs), which could provide important insight into new clinical therapeutic targets. Here, we review the genomic landscape of IMDs and analyse overlapping loci between diseases. There may be a need for more epigenetics studies to aid in the understanding of the transition from genotype to phenotype.

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Biology and signal transduction pathways of the Lymphotoxin-αβ/LTβR system

Cited by 61 publications

References 115 publications

Lymphotoxin β receptor signalling executesHelicobacter pylori-driven gastric inflammation in a T4SS-dependent manner

Lymphotoxin β receptor signalling executesHelicobacter pylori-driven gastric inflammation in a T4SS-dependent manner

Lymphotoxin, NF-ĸB, and Cancer: The Dark Side of Cytokines

The genomic landscape of human immune-mediated diseases

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