Biology, evolution, and medical importance of polyomaviruses: An update

Moens, Ugo; Krumbholz, Andi; Ehlers, Bernhard; Zell, Roland; Johne, Reimar; Calvignac‐Spencer, Sébastien; Lauber, Chris

doi:10.1016/j.meegid.2017.06.011

Cited by 123 publications

(158 citation statements)

References 354 publications

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“…The late coding region contains the genes of the structural proteins, like the major (VP1) and two minor capsid proteins. The approximately 500-bp-long non-coding control region contains regulatory elements and transcription promoters, the origin of DNA replication (Moens et al 2017b).…”

Section: Polyomavirusesmentioning

confidence: 99%

Virus–Host Coevolution with a Focus on Animal and Human DNA Viruses

et al. 2019

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Viruses have been infecting their host cells since the dawn of life, and this extremely long-term coevolution gave rise to some surprising consequences for the entire tree of life. It is hypothesised that viruses might have contributed to the formation of the first cellular life form, or that even the eukaryotic cell nucleus originates from an infection by a coated virus. The continuous struggle between viruses and their hosts to maintain at least a constant fitness level led to the development of an unceasing arms race, where weapons are often shuttled between the participants. In this literature review we try to give a short insight into some general consequences or traits of virus-host coevolution, and after this we zoom in to the viral clades of adenoviruses, herpesviruses, nucleo-cytoplasmic large DNA viruses, polyomaviruses and, finally, circoviruses.

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Section: Polyomavirusesmentioning

confidence: 99%

Virus–Host Coevolution with a Focus on Animal and Human DNA Viruses

et al. 2019

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“…Results published are summarized to date in Table 3. As mentioned previously, based on the prevalence data, direct human-to-human, indirect (via food, water, or surfaces), respiratory, and/or faecal-oral transmissions are suggested [42, 43]. Respiratory transmission and portal entry are also strengthened by some prevalence data of studies with tissue samples from the respiratory tract, namely adenoids, tonsils, and lung.…”

Section: Resultsmentioning

confidence: 90%

Survey of KI, WU, MW, and STL Polyomavirus in Cancerous and Non-Cancerous Lung Tissues

et al. 2017

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Background/Aims: The pathogenesis of the human polyomavirus (PyV) KI, WU, MW, and STL has not been elucidated yet. Respiratory transmission is suggested, but the site of the replication, tissue, and cell tropism is not clarified. KIPyV and WUPyV DNA and/or antigen were detected in normal lung tissues previously by others. In fact, a KIPyV DNA sequence was found in lung cancer samples. Up to date, there is no publication about the DNA prevalence of MWPyV and STLPyV neither in normal nor in cancerous lung tissues. The aim of the present study was to examine the DNA prevalence of these polyomaviruses in cancerous and non-cancerous lung tissue samples, in order to study the possible site for viral replication and/or persistence, and the potential association of these viruses with lung carcinogenesis as well. Methods: 100 cancerous and 47 non-cancerous, formalin-fixed paraffin-embedded lung tissue samples were studied for KIPyV, WUPyV, MWPyV, and STLPyV by real-time PCR. Results and Conclusion: Neither of the viruses was found in samples from small-cell, non-small-cell (adenocarcinoma, squamous-cell carcinoma and large-cell neuroendocrine lung cancer), mixed-type and non-differentiated lung carcinoma, and non-cancerous lung tissues (from patients with pneumonia, emphysema and fibrosis).

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“…While mammalian PyVs are highly host specific [12] there are data suggesting cross-species jumps of PyVs between closely related mammalian hosts. Previously, short-range intra-genus host-switching events of PyVs were identified in African horseshoe bats, occurring between Rh.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Polyomaviruses (PyVs) are non-enveloped icosahedral DNA viruses containing a circular and highly stable double-stranded DNA genome [11, 12]. PyVs can induce neoplastic transformation in cell culture [12], and are associated with malignancy in humans [13, 14] and raccoons [15]. Currently, 98 species carried by various mammals, birds and fish are recognized within the family Polyomaviridae by the International Committee on Taxonomy of Viruses (ICTV) and classified into four separate genera ( Alpha-, Beta-, Gamma- and Deltapolyomavirus ) with nine floating species [16].…”

Section: Introductionmentioning

confidence: 99%

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Extensive genetic diversity of bat-borne polyomaviruses reveals inter-family host-switching events

Tan

González²,

Sheng

et al. 2019

Preprint

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30 Polyomaviruses (PyVs) are small, double-stranded DNA tumor viruses carried by diverse 31 vertebrates. PyVs have previously been considered highly host restricted in mammalian hosts, 32 with host-switching events thought rare or nonexistent. Prior investigations have revealed 33 short-range host-switching events of PyVs in two different African bat species within the 34 horseshoe bat genus Rhinolophus. Herein, we have conducted a systematic investigation of PyVs 35 in 1,083 archived bat samples collected from five provinces across China, and identified 192 36 PyVs from 186 bats from 15 host species within 6 families (Rhinolophidae, Vespertilionidae, 37 Hipposideridae, Emballonuridae, Miniopteridae and Pteropodidae) representing 28 38 newly-described PyVs, indicative of extensive genetic diversity of bat PyVs. Surprisingly, two 39 PyVs were identified in multiple bat species from different families, and another PyV clustered 40 phylogenetically with PyVs carried by bats from a different host family, indicative of three 41 inter-family PyV host-switching events. The time to most recent common ancestor (tMRCA) of 42 the three events was estimated at 0.02-11.6 million years ago (MYA), which is inconsistent with 43 the estimated tMRCA of their respective bat hosts (36.3-66.7 MYA), and is most parsimoniously 44 explained by host-switching events. PyVs identified from geographically separated Chinese 45 horseshoe bat species in the present study showed close genetic identities, and clustered with 46 each other and with PyVs from African horseshoe bats, allowing assessment of the effects of 47 positive selection in VP1 within the horseshoe bat family Rhinolophidae. Correlation analysis 48 indicated that co-evolution with their hosts contributed much more to evolutionary divergence of 49 PyV than geographic distance. In conclusion, our findings provide the first evidence of . CC-BY 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/627158 doi: bioRxiv preprint 50 inter-family host-switching events of PyV in mammals and challenge the prevailing evolutionary 51 paradigm for strict host restriction of mammalian PyVs. 52 53 Author summary 54 Since the discovery of murine polyomavirus in the 1950s, polyomaviruses (PyVs) have been 55 considered both genetically stable and highly host-restricted in their mammalian hosts. In this 56 study, we have identified multiple cases of host-switching events of PyVs by large scale 57 surveillance in diverse bat species collected in China. These host-switching events occurred 58 between bat families living in the same colony, indicating that a large population with frequent 59 contacts between different bat species may represent an ecological niche facilitating PyV 60 host-switching. The cases studied involved members of bats from several families, including 61 horseshoe bats, which were previously found to harbor a number of highly virulent viruses to 62 both humans and...

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Biology, evolution, and medical importance of polyomaviruses: An update

Cited by 123 publications

References 354 publications

Virus–Host Coevolution with a Focus on Animal and Human DNA Viruses

Virus–Host Coevolution with a Focus on Animal and Human DNA Viruses

Survey of KI, WU, MW, and STL Polyomavirus in Cancerous and Non-Cancerous Lung Tissues

Extensive genetic diversity of bat-borne polyomaviruses reveals inter-family host-switching events

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