2018
DOI: 10.1016/bs.pmbts.2017.10.004
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Biology of GM3 Ganglioside

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Cited by 51 publications
(42 citation statements)
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“…The topic was recently reviewed [34]. Glycosphingolipid-enriched lipid rafts essentially contribute to immunological functions as, for example, activation of T cells [35][36][37][38].…”
Section: Glucosylceramide As Intermediate Of Glycosphingolipidsmentioning
confidence: 99%
“…The topic was recently reviewed [34]. Glycosphingolipid-enriched lipid rafts essentially contribute to immunological functions as, for example, activation of T cells [35][36][37][38].…”
Section: Glucosylceramide As Intermediate Of Glycosphingolipidsmentioning
confidence: 99%
“…The improvement in insulin sensitivity is partly mediated by AMP-DNM inhibition of glycosidases processing food polysaccharides, buffering sugar assimilation (4) and reduced GSL synthesis, which counteracts insulin resistance stemming from excessive gangliosides (1). In particular, excessive GM3 is thought to interfere with insulin signaling (26). Here we show that in addition to its capacity as an enzyme inhibitor of GSL metabolism, AMP-DNM modulates energy metabolism through influencing endocrine factors acting on brain neural circuits controlling energy metabolism.…”
Section: Discussionmentioning
confidence: 74%
“…We previously reported that AMP-DNM treatment improves insulin sensitivity, corrects glycemic control, and reduces food intake in ob/ob mice (4,5,26) and obese diabetic rats (4). In addition, orally administered AMP-DNM has been shown to lower brain GSLs and inhibit the cellular enzyme GBA2, indicating that AMP-DNM may enter the brain and inhibit its target enzymes (27).…”
Section: Discussionmentioning
confidence: 99%
“…A single injection of DANA did not affect insulin resistance 26 . In addition, the ganglioside GM3 induces insulin resistance 27 . Although Neu3 is a key enzyme involved in ganglioside hydrolysis [28][29][30] , GM3 content is hardly altered by treatment with an siRNA targeting Neu3 31,32 .…”
Section: Discussionmentioning
confidence: 99%