Biology of Pathogenic Actinobacteria

Chawla, Kiran; Prakash, Peralam Yegneswaran

doi:10.1016/b978-0-444-63994-3.00015-1

Cited by 2 publications

(1 citation statement)

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“…The 16S rRNA amplicon sequencing analysis could not identify specific taxa, and these microbes are generally found in the environment. While taxa associated with Actinobacteria and Nocardia have been known to cause infections ( 75 – 78 ), there is no evidence to suggest the organisms identified posed any threat to health care workers. However, their presence does support the need to continue strict sterile techniques and to regularly sanitize testing areas.…”

Section: Discussionmentioning

confidence: 99%

Characterization of SARS-CoV-2 Distribution and Microbial Succession in a Clinical Microbiology Testing Facility during the SARS-CoV-2 Pandemic

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Characterization of SARS-CoV-2 Distribution and Microbial Succession in a Clinical Microbiology Testing Facility during the SARS-CoV-2 Pandemic

et al. 2023

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Connecting genomic islands across prokaryotic and phage genomes via protein families

Aldaihani

Heath

2023

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Prokaryotic genomes evolve via horizontal gene transfer (HGT), mutations, and rearrangements. A noteworthy part of the HGT process is facilitated by genomic islands (GIs). While previous computational biology research has focused on developing tools to detect GIs in prokaryotic genomes, there has been little research investigating GI patterns and biological connections across species. We have pursued the novel idea of connecting GIs across prokaryotic and phage genomes via patterns of protein families. Such patterns are sequences of protein families frequently present in the genomes of multiple species. We combined the large data set from the IslandViewer4 database with protein families from Pfam while implementing a comprehensive strategy to identify patterns making use of HMMER, BLAST, and MUSCLE. we also implemented Python programs that link the analysis into a single pipeline. Research results demonstrated that related GIs often exist in species that are evolutionarily unrelated and in multiple bacterial phyla. Analysis of the discovered patterns led to the identification of biological connections among prokaryotes and phages. These connections suggest broad HGT connections across the bacterial kingdom and its associated phages. The discovered patterns and connections could provide the basis for additional analysis on HGT breadth and the patterns in pathogenic GIs.

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Biology of Pathogenic Actinobacteria

Cited by 2 publications

References 44 publications

Characterization of SARS-CoV-2 Distribution and Microbial Succession in a Clinical Microbiology Testing Facility during the SARS-CoV-2 Pandemic

Characterization of SARS-CoV-2 Distribution and Microbial Succession in a Clinical Microbiology Testing Facility during the SARS-CoV-2 Pandemic

Connecting genomic islands across prokaryotic and phage genomes via protein families

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