Biology of the Rotator Cuff Tendon

Blevins, Field T.; Djurasovic, Mladen; Flatow, Evan L.; Vogel, Kathryn G.

doi:10.1016/s0030-5898(05)70260-1

Cited by 145 publications

(99 citation statements)

References 72 publications

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“…The effect of tissue composition on tendon strain could not be determined from this study since no measure of tissue composition was recorded. Although previous research has reported compositional differences between the rotator cuff and other tendons [6], compositional differences between the joint-side and bursal-side supraspinatus tendon regions have not been shown. Thus, insufficient evidence exists to implicate tissue composition as the most likely parameter for explaining differences in strain between joint-side and bursal-side regions.…”

Section: J Bey Et Al I Joiimnl Of Orthopnedic Riwurch 20 (2002)mentioning

confidence: 74%

Intratendinous strain fields of the intact supraspinatus tendon: the effect of glenohumeral joint position and tendon region

Bey

Song

Wehrli

et al. 2002

Journal Orthopaedic Research

108

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Rotator cuff tears are a common shoulder pathology and are hypothesized to relate to excessive tissue deformation. Few data exist, however, describing deformation of the rotator cuff as an intact, functional unit. Our purpose was to determine regional variations of intratendinous rotator cuff strain over a range of clinically relevant joint positions. A novel, MRI-based technique was utilized to quantify intratendinous strains in cadaveric shoulder specimens at 15", 30°, 45", and 60" of glenohumeral abduction in the scapular plane. The strain data were grouped into superior, middle, and inferior locations across the region where most rotator cuff tears occur clinically. A repeated measures ANOVA assessed the effects of joint position and tendon region on intratendinous strain.Few differences in intratendinous strain existed across tendon regions, but joint position had a pronounced effect. Specifically, intratendinous strain increased with increasing joint angle, and the 60" strain was significantly greater than the 15" strain across all tendon regions. These data suggest that joint position plays a larger role in rotator cuff mechanics than previously believed. Future studies will utilize this technique for quantifying intratendinous strain to assess the effects of partial-thickness rotator cuff tears.

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Section: J Bey Et Al I Joiimnl Of Orthopnedic Riwurch 20 (2002)mentioning

confidence: 74%

Intratendinous strain fields of the intact supraspinatus tendon: the effect of glenohumeral joint position and tendon region

Bey

Song

Wehrli

et al. 2002

Journal Orthopaedic Research

108

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“…These markers were COL-I (main component of extracellular tendon matrix (Blevins et al, 1997;Kannus, 2000)), COL-III (increased in early tendon healing (Takahasih et al, 2002) and experimentally in chronic tears (Yokota et al, 2005)), decorin (most important proteoglycan in tendon (Rahaman and Mao, 2005;Yoon and Halper, 2005)) and biglycan (a proteoglycan present in tendon, cartilage and bone (Yoon and Halper, 2005)), aggrecan (a proteoglycan, present in cartilage as well as in compressed tendon regions (Rees et al, 2000), and tenascin C (a glycoprotein, part of tendon cell adaptation to compression (Martin et al, 2003)). …”

Section: Characterization Of Tendon Cell Cultures Of the Human Rotatomentioning

confidence: 99%

Characterization of tendon cell cultures of the human rotator cuff

Pauly

Klatte²,

Strobel³

et al. 2010

eCM

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Rotator cuff tears are common soft tissue injuries of the musculoskeletal system that heal by formation of repair tissue and may lead to high retear rates and joint dysfunction. In particular, tissue from chronic, large tendon tears is of such degenerative nature that it may be prone to retear after surgical repair. Besides several biomechanical approaches, biologically based strategies such as application of growth factors may be promising for increasing cell activity and production of extracellular tendon matrix at the tendon-to-bone unit. As a precondition for subsequent experimental growth factor application, the aim of the present study was to establish and characterize a human rotator cuff tendon cell culture.Long head biceps (LHB)-and supraspinatus muscle (SSP)-tendon samples from donor patients undergoing shoulder surgery were cultivated and examined at the RNA level for expression of collagen type-I, -II and -III, biglycan, decorin, tenascin-C, aggrecan, osteocalcin, tenomodulin and scleraxis (by Real-time PCR). Finally, results were compared to chondrocytes and osteoblasts as control cells.An expression pattern was found which may reflect a human rotator cuff tenocyte-like cell culture. Both SSP and LHB tenocyte-like cells differed from chondrocyte cell cultures in terms of reduced expression of collagen type-II (p≤0.05) and decorin while higher levels of collagen type-I were seen (p≤0.05). With respect to osteoblasts, tenocytelike cells expressed lower levels of osteocalcin (p≤0.05) as well as tenascin C, biglycan and collagen type-III. Expression of scleraxis, tenomodulin and aggrecan was similar between all cell types.This study represents a characterization of tenocytelike cells from the human rotator cuff as close as possible. It helps analyzing their biological properties and allows further studies to improve production of tendon matrix and osteofibroblastic integration at the tendon-bone unit following tendon repair.

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“…These soft connective tissues consist of collagen fiber bundles embedded in an extracellular matrix composed largely of proteoglycans, water, and glycoproteins. 13 Individual genes or combinations of genes likely regulate whole tendon and ligament properties in a hierarchical fashion, from matrix synthesis through to fibril and fascicle assembly and tissue organization. Various investigators have assessed the contributions of selected matrix components (e.g., cytokines, proteoglycans) to tendon structure, composition, and mechanical properties using transgenic and knockout mice.…”

Section: Introductionmentioning

confidence: 99%

Variability in tendon and knee joint biomechanics among inbred mouse strains

Wang

Banack

Tsai

et al. 2006

Journal Orthopaedic Research

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Hereditary factors are thought to be responsible for impaired tendon function and joint laxity. The present study investigated the genotypic variability of knee laxity and stiffness and tendon mechanical and geometric properties among 16-week-old female A/J, C57BL/6J (B6), and C3H/HeJ (C3H) inbred mice. In one group of mice, knee mechanics were quantified using a custom loading apparatus enabling translation of the tibia against a stationary femur. In a second group, flexor digitorum longus and Achilles tendons from the left hind limb underwent biomechanical testing, while those of the contralateral limb were analyzed histologically for determination of crosssectional area. Our results demonstrate that tendon and joint mechanics varied significantly among the inbred mouse strains, indicating that biomechanical properties are genetically determined. A/J mouse knees exhibited greater laxity (p < 0.001) and lower stiffness (p < 0.001) compared to those of the B6 and C3H mice. The genotypic differences in whole joint properties were similar to those of the tendons' structural biomechanical traits. Although body mass did not differ (p > 0.2) among the three strains, significant genotypic differences were found at the whole tendon, material quality, and morphological levels of the tissue hierarchy. Furthermore, genetic regulation of tendon mechanical properties varied with anatomic site. Patterns of genotypic differences in tendon size were not consistent with those of biomechanical properties, suggesting that unique combinations of structural and compositional factors contribute to tendon growth, adaptation, and development. Therefore, the three inbred strains constitute a useful experimental model to elucidate genetic control of structure-function relationships in normal and healing tendons and ligaments.

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Biology of the Rotator Cuff Tendon

Cited by 145 publications

References 72 publications

Intratendinous strain fields of the intact supraspinatus tendon: the effect of glenohumeral joint position and tendon region

Intratendinous strain fields of the intact supraspinatus tendon: the effect of glenohumeral joint position and tendon region

Characterization of tendon cell cultures of the human rotator cuff

Variability in tendon and knee joint biomechanics among inbred mouse strains

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