Biology of Vanadium-Based Compounds for Treatment of Diabetes

Yang, Xiaoda

doi:10.1016/b978-0-12-409547-2.14295-7

Cited by 3 publications

(1 citation statement)

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“…Many studies have described the ability of the metal vanadium (as ions and in complexes) to treat diabetes [7, 8] and fight cancer [9]. The latter has been attributed to vanadium's potent insulin-like effects in the liver, skeletal muscle, and adipose tissue [7].…”

Section: Introductionmentioning

confidence: 99%

A Novel Oxidovanadium (IV)-Orotate Complex as an Alternative Antidiabetic Agent: Synthesis, Characterization, and Biological Assessments

Naglah

Al-Omar

Almehizia

et al. 2018

BioMed Research International

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Diabetes is an increasingly common metabolic disorder with high comorbidity and societal and personal costs. Insulin replacement therapy is limited by a lack of oral bioavailability. Recent studies suggest vanadium has therapeutic potential. A newly synthesized complex between oxidovanadium (IV) and orotic acid (OAH3), [(OAH1)(VO)(NH3)2].3H2O, was characterized using spectroscopic and thermogravimetric techniques. In vivo potential was assessed in a streptozocin-induced rat model of diabetes. OAH3 acts as a bidentate ligand in the formation of the dark green, crystalline oxidovanadium (IV) complex in a square pyramidal configuration. Treatment with oxidovanadium (IV)-orotate in vivo significantly improved many biochemical parameters with minimal toxicity and restored pancreatic and hepatic histology. The results of the present work describe a safe, new compound for the treatment of diabetes.

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