Biology of Wound Healing

Carrico, T J; Mehrhof, Austin I.; Cohen, I. Kelman

doi:10.1016/s0039-6109(16)43388-8

Cited by 113 publications

(70 citation statements)

References 57 publications

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“…The American Diabetes Association lists the hazards of treating diabetic feet with hot water bottles, heating pads, and hot water soaks but does not alert the readers to the actual severity and consequences of injuries that can ensue (1). There have been numerous anecdotal literature reports about diabetic foot burns from electric heating pads, foot spas, and water baths (2)(3)(4)(5)(6)(7)(8)(9). Diabetic patients are known to experience more inf e c t i o n s i n c l e a n w o u n d s t h a n nondiabetic patients and to heal more slowly, especially in the extremities (10 -11).…”

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confidence: 99%

Infections in Diabetic Burn Patients

2004

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OBJECTIVE -Diabetic burn patients comprise a significant population in burn centers. The purpose of the study was to determine the demographic characteristics of diabetic burn patients and their rate of community-acquired and nosocomial infections.RESEARCH DESIGN AND METHODS -This was a 46-month retrospective chart and patient registry review comparing diabetic with nondiabetic burn patients. Statistical analysis consisted of means Ϯ SD, descriptive statistics, one-way ANOVA, and 2 tests. , P ϭ 0.001). Adult diabetic burns had a significant increase in sepsis (P Ͻ 0.002) and community-acquired burn wound cellulitis (P Ͻ 0.001) compared with adult nondiabetic patients; and senior diabetic patients had a significantly increased frequency of urinary tract infections compared with senior nondiabetic burn patients (P Ͻ 0.04).The most common organisms in diabetic burn infections were Streptococcus, Proteus, Pseudomonas, Candida species, and MRSA (methicillin-resistant Staphylococcus aureus). Forty-two percent of the diabetic patients were admitted during the winter months and 25% in the spring. Only 49 of 130 (38%) diabetic burn patients presented for treatment within 48 h after injury compared with 669 of 1,126 (62%) nondiabetic patients (P ϭ 0.001).CONCLUSIONS -Peripheral neuropathy may have precipitated and delayed medical treatment in lower-extremity burns of diabetic patients. Hospitalized diabetic burn patients were also at an increased risk for nosocomial infections, which prolonged hospitalization. Diabetic patient education must include not only caution about potential burn mishaps but also educate concerning the complications from burns that may ensue. Diabetes Care 27:229 -233, 2004A pproximately 17 million (6.2%) of the U.S. population are diabetic; this disease is the seventh leading cause of death in the U.S. (1). The American Diabetes Association lists the hazards of treating diabetic feet with hot water bottles, heating pads, and hot water soaks but does not alert the readers to the actual severity and consequences of injuries that can ensue (1). There have been numerous anecdotal literature reports about diabetic foot burns from electric heating pads, foot spas, and water baths (2-9). Diabetic patients are known to experience more inf e c t i o n s i n c l e a n w o u n d s t h a n nondiabetic patients and to heal more slowly, especially in the extremities (10 -11). The purpose of this study was to determine the demographic characteristics of diabetic burn patients at a large urban hospital and compare their propensity for nosocomial infections with that of the general burn population. RESEARCH DESIGN AND METHODS Burn careResuscitative fluids were administered dependent on requirements for all injuries using modified Parkland formula guidelines. All patients were treated with closed silver sulfadiazine-embedded gauze dressings or Collagenase Santyl (Advance Biofactures, Lynbrook, NY), an enzymatic debriding product, until either the wound healed or surgical intervention was initiated. Arterial blood ...

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confidence: 99%

Infections in Diabetic Burn Patients

2004

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“…[1,2] Anastomotic leak in colorectal surgery increases the morbidity and mortality rates. [3,4] Tissue blood flow and oxygenation are very significant factors contributing to the healing of colonic anastomosis, whereas ischemia and infection are known to be the most important factors interrupting the healing process.…”

Section: Resultsmentioning

confidence: 99%

İskemik kolon anastomozlarının iyileşmesi üzerine pentoxifylline ve vinpocetinenin etkisi. (Deneysel Çalışma)

Sümer¹

2011

Ulus Travma Acil Cerrahi Derg

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“…So wound needs serious assessment and appropriate management. There are several ways to manage the wounds including the most important is suturing [2][3][4][5] . Wound assessment by doctor arises question "Will this wound needs stitches?"…”

Section: Introductionmentioning

confidence: 99%