Biolubrication synergy: Hyaluronan – Phospholipid interactions at interfaces

Dédinaité, Andra; Wieland, D. C. Florian; Bełdowski, Piotr; Claesson, Per M.

doi:10.1016/j.cis.2019.102050

Cited by 50 publications

(52 citation statements)

References 54 publications

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“…Addition of calcium ions results in increased electrophoretic mobility for both DPPC vesicles alone and for DPPC vesicles decorated by hyaluronan. It appears that binding of hyaluronan to the DPPC vesicles has a rather low effect on the ability of calcium ions to bind to the DPPC headgroup, even though modelling has shown that calcium mediated ion bridges form between the phosphate group of DPPC and the carboxylate group of HA [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

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Influence of the Molecular Weight and the Presence of Calcium Ions on the Molecular Interaction of Hyaluronan and DPPC

et al. 2020

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Hyaluronan is an essential physiological bio macromolecule with different functions. One prominent area is the synovial fluid which exhibits remarkable lubrication properties. However, the synovial fluid is a multi-component system where different macromolecules interact in a synergetic fashion. Within this study we focus on the interaction of hyaluronan and phospholipids, which are thought to play a key role for lubrication. We investigate how the interactions and the association structures formed by hyaluronan (HA) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) are influenced by the molecular weight of the bio polymer and the ionic composition of the solution. We combine techniques allowing us to investigate the phase behavior of lipids (differential scanning calorimetry, zeta potential and electrophoretic mobility) with structural investigation (dynamic light scattering, small angle scattering) and theoretical simulations (molecular dynamics). The interaction of hyaluronan and phospholipids depends on the molecular weight, where hyaluronan with lower molecular weight has the strongest interaction. Furthermore, the interaction is increased by the presence of calcium ions. Our simulations show that calcium ions are located close to the carboxylate groups of HA and, by this, reduce the number of formed hydrogen bonds between HA and DPPC. The observed change in the DPPC phase behavior can be attributed to a local charge inversion by calcium ions binding to the carboxylate groups as the binding distribution of hyaluronan and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine is not changed.

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Section: Resultsmentioning

confidence: 99%

“…Indeed, theoretical calculations confirm that calcium ions promote long-lasting interactions between the carboxylate group of HA and the phosphate group of the phospholipid by creating a bridging connection [ 44 ]. Further, a reinforcement of the HA network by the adsorption of phospholipids has been observed [ 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of the Molecular Weight and the Presence of Calcium Ions on the Molecular Interaction of Hyaluronan and DPPC

et al. 2020

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“…This fact suggests that it is increasing interest in the creation of new materials based on such blends. Apart from experimental study on HA materials there are also studies regarding molecular dynamic simulation of this macromolecule behavior in the presence of water and other molecules [ 103 , 104 ].…”

Section: Possible Application Of New Materials Based On the Blendsmentioning

confidence: 99%

Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

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In this review, we provide a report on recent studies in the field of research on the blends of hyaluronic acid with other natural polymers, namely collagen and chitosan. Hyaluronic acid has attracted significant interest in biomedical and cosmetic applications due to its interesting properties. In recent years, blends of hyaluronic acid with other polymers have been studied for new materials development. New materials may show improved properties that are important in the biomedical applications and in cosmetic preparations. In this review paper, the structure, preparation, and properties of hyaluronic acid blends with collagen and chitosan have been discussed and examples of new materials based on such blends have been presented. A comparison of the currently available information in the field has been shown. Future aspects in the field of hyaluronic acid blends and their applications in the biomedical and cosmetic industry have also been mentioned.

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“…In fact, the presence of hyaluronic acid led to the formation of a densely packed supramolecular structure, thus determining a reduction of the diffusion coefficient of the resulting gel [39]. In addition to this, the release behavior can also be determined in part by the retention of SLNs into the gel since, interestingly, recent modelling and experimental studies have shown that hyaluronic acid and phospholipids interact via hydrogen bonds and hydrophobic forces, thus leading to strong associations [40].…”

Section: Tape Stripping Testmentioning

confidence: 99%

Viscosified Solid Lipidic Nanoparticles Based on Naringenin and Linolenic Acid for the Release of Cyclosporine A on the Skin

et al. 2020

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Psoriasis is one of the most common human skin disorders. Although its pathogenesis is complex and not completely know, the hyperactivation of the immune system seem to have a key role. In this regard, among the most effective systemic therapeutics used in psoriasis, we find cyclosporine, an immunosuppressive medication. However, one of the major problems associated with the use of cyclosporine is the occurrence of systemic side effects such as nephrotoxicity, hypertension, etc. The present work fits in this context and its aim is the design of suitable platforms for cyclosporine topical release in psoriasis treatment. The main objective is to achieve local administration of cyclosporine in order to reduce its systemic absorption and, consequently, its side effects. In order to improve dermal penetration, solid lipid nanoparticles (SLNs) are used as carriers, due to their lipophilicity and occlusive properties, and naringenin and linolenic acid are chosen, due to their properties, as starting materials for SLNs design. In order to have dermatological formulations and further modulate drug release, SLNs are incorporated in several topical vehicles obtaining gels with different degree of lipophilicity. Potential applications for psoriasis treatment were evaluated by considering the encapsulation efficiency, release profiles, in vitro skin permeation, and anti-inflammatory effects.

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Biolubrication synergy: Hyaluronan – Phospholipid interactions at interfaces

Cited by 50 publications

References 54 publications

Influence of the Molecular Weight and the Presence of Calcium Ions on the Molecular Interaction of Hyaluronan and DPPC

Influence of the Molecular Weight and the Presence of Calcium Ions on the Molecular Interaction of Hyaluronan and DPPC

Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

Viscosified Solid Lipidic Nanoparticles Based on Naringenin and Linolenic Acid for the Release of Cyclosporine A on the Skin

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