Biomarker Changes in Pediatric Patients With COVID-19: A Retrospective Study from a Single Center Database

Sava, Cristian; Bodog, Teodora-Maria; Niulas, Larisa Roxana; Iuhas, Alin Remus; Marinău, Cristian Phillip; Negruț, Nicoleta; Balmoș, Andreea Bianca; Pasca, Bianca; Roman, Nadinne; Nistor-Cseppentö, Delia Carmen

doi:10.21873/invivo.13019

Cited by 7 publications

(10 citation statements)

References 56 publications

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“…Sava et al analyzed a group of 234 COVID-19 pediatric cases, describing leukopenia (20.4%), lymphopenia (35%) and neutropenia (17.5%) as the most common changes in WBC. Their data supports our results ( 38 ).…”

Section: Discussionsupporting

confidence: 93%

Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study

Pavelescu,

Dinulescu,

Păsărică

et al. 2024

Front. Pediatr.

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BackgroundComplete blood count, C-reactive protein and transaminases are routine laboratory parameters investigated in children with infections, including COVID 19. We aimed to evaluate the diagnostic accuracy of these parameters in children diagnosed with COVID 19.MethodsAt the time of admission, children with COVID 19 suggestive symptoms were tested RT-PCR for SARS CoV-2 and were allocated to either the study group (RT-PCR SARS CoV-2 positive) or control group (RT-PCR SARS CoV-2 negative). All children were evaluated by complete blood count, CRP, and transaminases.ResultsWhen comparing the two groups, we identified significantly lower values for leukocytes (p < 0.001), neutrophils (p < 0.001), lymphocytes (p < 0.001) and thrombocytes (p = 0.014), but no significantly different values for CRP (p = 0.916) and monocytes (p = 0.082). A diagnostic score for COVID-19 was compiled using the abovementioned parameters—presence of fever, number of lymphocytes and aspartate-aminotransferase. Performance was tested, showing a positive discrimination value (AUC of 0.703)—81.5% sensitivity, 50.6% specificity.ConclusionsThe leukocytes, neutrophils and lymphocytes have significantly lower values in COVID-19 children. The proposed score based on the presence of fever the values of lymphocytes and AST has a good sensitivity in predicting COVID-19 infection.

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Section: Discussionsupporting

confidence: 93%

Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study

Pavelescu,

Dinulescu,

Păsărică

et al. 2024

Front. Pediatr.

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“…This is corroborated by Cocos et al, Hutanu et al, Todor et al Restea et al [ 26 , 29 , 36 , 48 ]. From this point of view, similar changes could be observed in pediatric cases [ 22 , 23 , 30 , 39 , 112 ].…”

Section: Resultssupporting

confidence: 70%

“…On rare occasions, thrombocytopenia might be observed [ 22 , 35 , 38 , 64 , 80 , 112 ]. Even rarer were the cases of thrombocytosis [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

“…Even rarer were the cases of thrombocytosis [ 39 ]. Another hematological problem, which is mostly linked to iron problems, is that anemia can also be present [ 23 , 36 , 37 , 38 , 39 , 40 , 112 ]. In the study by Uta et al, anemia was observed in pregnant women with SARS-CoV-2 infection, and they were urged toward supplementation therapies [ 88 ].…”

Section: Resultsmentioning

confidence: 99%

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COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review

Musat,

Sorop,

Sorop

et al. 2023

Life

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COVID-19 has significantly impacted the whole world, and Romania was no exception. Biomarkers play a crucial role in understanding and managing the disease. However, research regarding laboratory analyses for patients with COVID-19 is fairly limited. For detection, PCR testing is still considered the golden standard, while antibodies are still useful for monitoring both patients and their vaccination status. In our country, biomarkers such as CRP, LDH, transaminases, cardiac, and iron markers have been used to assess the status of patients and even predict illness outcome. CRP, IL-6, LDH, FER, fibrinogen, creatinine, and vitamin D levels have been associated with increased severity, risk of ICU admission, and death. Cardiac markers and D-dimers are also good predictors, but their role seems more important in patients with complications. HDL cholesterol and BUN levels were also suggested as potential biomarkers. Hematological issues in SARS-CoV-2 infections include neutrophilia, lymphopenia and their ratio, while PCT, which is a marker of bacterial infections, is better to be used in patients with co- or supra-infections. The current research is a narrative review that focuses on the laboratory results of Romanian COVID-19 patients. The goal of this article is to provide an update on the research on biomarkers and other laboratory tests conducted inside the borders of Romania and identify gaps in this regard. Secondly, options for further research are discussed and encouraged.

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“…TB care and prevention were particularly affected by the redirection of human, financial and other resources to the COVID-19 response. Furthermore, public health measures resulted in reducing access to TB diagnosis and treatment services [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

The Use of Xpert MTB/RIF Ultra Testing for Early Diagnosis of Tuberculosis: A Retrospective Study from a Single-Center Database

Sava

Sava²,

Drăgan

et al. 2023

Genes

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Tuberculosis (TB) is a multisystemic contagious disease produced by Mycobacterium tuberculosis complex bacteria (MTBC), with a prevalence of 65:100,000 inhabitants in Romania (six times higher than the European average). The diagnosis usually relies on the detection of MTBC in culture. Although this is a sensitive method of detection and remains the “gold standard”, the results are obtained after several weeks. Nucleic acid amplification tests (NAATs), being a quick and sensitive method, represent progress in the diagnosis of TB. The aim of this study is to assess the assumption that NAAT using Xpert MTB/RIF is an efficient method of TB diagnosis and has the capacity to reduce false-positive results. Pathological samples from 862 patients with TB suspicion were tested using microscopic examination, molecular testing and bacterial culture. The results show that the Xpert MTB/RIF Ultra test has a sensitivity of 95% and a specificity of 96.4% compared with 54.8% sensitivity and 99.5% specificity for Ziehl–Neelsen stain microscopy, and an average of 30 days gained in the diagnosis of TB compared with bacterial culture. The implementation of molecular testing in TB laboratories leads to an important increase in early diagnostics of the disease and the prompter isolation and treatment of infected patients.

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Biomarker Changes in Pediatric Patients With COVID-19: A Retrospective Study from a Single Center Database

Cited by 7 publications

References 56 publications

Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study

Hematological profile, inflammatory markers and serum liver enzymes in COVID 19 positive children vs. COVID 19 negative ones—a comparative study

COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review

The Use of Xpert MTB/RIF Ultra Testing for Early Diagnosis of Tuberculosis: A Retrospective Study from a Single-Center Database

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