Biomarker predictors of survival in patients with ventilator-associated pneumonia

Afifi, Mohamed; Elhendy, Amera A; Eltaweel, Moataz M; Soliman, Neven; El-Feky, Elham M; Salama, Asmaa E

doi:10.4103/1110-2098.156004

Cited by 2 publications

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“…The role of PCT and CRP biomarkers in predicting the survival and mortality in patients with VAP has been assessed in several studies. [19][20][21] An observational cohort study was conducted in 71 patients with VAP by Seligman et al (2011). The accuracy of CRP, PCT, and SOFA was compared in predicting the VAP mortality.…”

Section: Biomarkers -Their Role In Prediction Of Disease Severity Andmentioning

confidence: 99%

The significance of modified PIRO scoring with nlr biomarker on enhancing mortality prediction of patients with ventilators-associated pneumonia in intensive care unit

Aprilnita

Senapathi

Budiarta

et al. 2018

Bali J Anaesthesiol

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Ventilator-associated pneumonia (VAP) is a pulmonary infection that occurs as a mechanical ventilator-related disease which accounts for almost 80% of hospital-acquired pneumonia with of high mortality rate, lengthens the hospital-stay rate and increases health costs. To provide a description of the likelihood of the patient' s life expectancy, mortality, and prognosis of patients in ICU, a scoring system should be utilized in order to assess the severity of the disease and estimate mortality during hospital treatment. The PIRO scoring system is a comprehensive concept that provides good validity and derivation in predicting mortality risk in a wide range severity of the disease so that it is very useful in the selection or categorization of patients, especially those admitted to the ICU with VAP. A conjunction or integration with a simple biomarker such as Neutrophil-to-lymphocyte ratio (NLR) provides a better performance of the tool in regards to the predictive value in VAP mortality risk estimation. Since the NLR has a strong predictive value, is simple, lowcost, and easily available compared to other biomarkers, therefore it is practical and useful for prognostic indications for VAP with conjunction with the PIRO score where medical facilities are lacking.

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Section: Biomarkers -Their Role In Prediction Of Disease Severity Andmentioning

confidence: 99%

The significance of modified PIRO scoring with nlr biomarker on enhancing mortality prediction of patients with ventilators-associated pneumonia in intensive care unit

Aprilnita

Senapathi

Budiarta

et al. 2018

Bali J Anaesthesiol

View full text Add to dashboard Cite

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Prognostic biomarkers in predicting mortality in respiratory patients with ventilator-associated pneumonia

et al. 2021

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Background Ventilator-associated pneumonia (VAP) is the most common nosocomial infection. Red cell distribution width (RDW) and neutrophil-lymphocyte ratio (NLR) are prognostic factors to mortality in different diseases. The aim of this study is to evaluate prognostic efficiency RDW, NLR, and the Sequential Organ Failure Assessment (SOFA) score for mortality prediction in respiratory patients with VAP. Results One hundred thirty-six patients mechanically ventilated and developed VAP were included. Clinical characteristics and SOFA score on the day of admission and at diagnosis of VAP, RDW, and NLR were assessed and correlated to mortality. The average age of patients was 58.80 ± 10.53. These variables had a good diagnostic performance for mortality prediction AUC 0.811 for SOFA at diagnosis of VAP, 0.777 for RDW, 0.728 for NLR, and 0.840 for combined of NLR and RDW. The combination of the three parameters demonstrated excellent diagnostic performance (AUC 0.889). A positive correlation was found between SOFA at diagnosis of VAP and RDW (r = 0.446, P < 0.000) and with NLR (r = 0.220, P < 0.010). Conclusions NLR and RDW are non-specific inflammatory markers that could be calculated quickly and easily via routine hemogram examination. These markers have comparable prognostic accuracy to severity scores. Consequently, RDW and NLR are simple, yet promising markers for ICU physicians in monitoring the clinical course, assessment of organ dysfunction, and predicting mortality in mechanically ventilated patients. Therefore, this study recommends the use of blood biomarkers with the one of the simplest ICU score (SOFA score) in the rapid diagnosis of critical patients as a daily works in ICU.

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Biomarker predictors of survival in patients with ventilator-associated pneumonia

Cited by 2 publications

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The significance of modified PIRO scoring with nlr biomarker on enhancing mortality prediction of patients with ventilators-associated pneumonia in intensive care unit

The significance of modified PIRO scoring with nlr biomarker on enhancing mortality prediction of patients with ventilators-associated pneumonia in intensive care unit

Prognostic biomarkers in predicting mortality in respiratory patients with ventilator-associated pneumonia

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