2022
DOI: 10.1182/bloodadvances.2021005710
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Biomarker signatures in cancer patients with and without venous thromboembolism events: a substudy of CASSINI

Abstract: Cancer is associated with an increased risk of venous thromboembolism (VTE). In the CASSINI study, ambulatory cancer patients with a Khorana risk score ≥2 had a reduced risk of VTE while receiving rivaroxaban. This analysis used blood samples from CASSINI to compare biomarker levels between patients with and without VTE. VTE occurred in 62 patients during the 6 months of CASSINI (cases), and they were matched by age, sex, cancer type, tumor stage, and Khorana score to 62 controls. Baseline blood samples were a… Show more

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Cited by 12 publications
(13 citation statements)
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“…We propose proteins across the biological systems as putative protein biomarkers that can track disease progression and severity over time and aim to provide unique patterns of response for the design of a biomarker signature unique to C. neoformans. Such approaches of protein biomarker signatures are being developed for neurological disorders 71 , aging 72 , and cancer [73][74][75] , as well as recently advanced for COVID-19 76 applications; however, contributions to infectious diseases, particularly for fungal pathogens, have been severely limited 77 . Here, we develop a pipeline for the comprehensive temporal proteomic profiling of C. neoformans infection using a murine model with spatial consideration confined to the spleen; however, our discoveries support new biological insight into mechanisms driving cryptococcosis and propose a strategy to explore tissue-specific biomarkers for effective and efficient diagnosis, monitoring, and treatment of cryptococcosis.…”
Section: Discussionmentioning
confidence: 99%
“…We propose proteins across the biological systems as putative protein biomarkers that can track disease progression and severity over time and aim to provide unique patterns of response for the design of a biomarker signature unique to C. neoformans. Such approaches of protein biomarker signatures are being developed for neurological disorders 71 , aging 72 , and cancer [73][74][75] , as well as recently advanced for COVID-19 76 applications; however, contributions to infectious diseases, particularly for fungal pathogens, have been severely limited 77 . Here, we develop a pipeline for the comprehensive temporal proteomic profiling of C. neoformans infection using a murine model with spatial consideration confined to the spleen; however, our discoveries support new biological insight into mechanisms driving cryptococcosis and propose a strategy to explore tissue-specific biomarkers for effective and efficient diagnosis, monitoring, and treatment of cryptococcosis.…”
Section: Discussionmentioning
confidence: 99%
“…We propose proteins across the biological systems as putative protein biomarkers that can track disease progression and severity over time and aim to provide unique patterns of response for the design of a biomarker signature unique to C. neoformans . Such approaches of protein biomarker signatures are being developed for neurological disorders, aging, and cancer, as well as recently advanced for COVID-19 applications; however, contributions to infectious diseases, particularly for fungal pathogens, have been severely limited . Here, we develop a pipeline for the comprehensive temporal proteomic profiling of C. neoformans infection using a murine model with spatial consideration confined to the spleen; however, our discoveries support new biological insight into mechanisms driving cryptococcosis and propose a strategy to explore tissue-specific biomarkers for effective and efficient diagnosis, monitoring, and treatment of cryptococcosis.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, CFHR5 was associated with VTE independent of D-Dimer or C-reactive proteins; however, it was not significantly associated with recurrent VTE events. It is important to note that multiple studies profiling the proteins present in VTE patients' plasma have identified biomarker candidates (Table 1), but consensus on any single biomarker is lacking [55][56][57][58][59][60][61][62][63]. In subsequent experiments performed by Iglesias et.…”
Section: Diagnostic Developmentmentioning
confidence: 99%
“…Anti-inflammatory negative regulator of NF-kB [82] Platelet derived growth factor b Demonstrates paracrine growth factor activity and chemoattractant for vascular smooth muscle cells and pericytes [83] Von Willebrand factor Stabilization of coagulation Factor VIII and mediating platelet adhesion to subendothelial collagen [84] Growth arrest specific 6 Vitamin K dependent TAM receptor ligand; Implicated in platelet and leukocyte recruitment, platelet aggregation, and endothelial activation [85] Blostein et al [57] and Schnegg-Kaufmann et al [58] Integrins subunits b1, b2, and b3 Extracellular matrix and inter-cellular adhesion receptors [86] Song et al [59] Bleomycin hydrolase Regulates major histocompatibility complex class I ligand generation [87] Memon et al [60] and Khorana et al [62] Soluble Osteopontin Macrophage and T cell chemoattractant mediating chronic inflammation [88] P-Selectin Mediates leukocyte and platelet adhesion to the endothelium [89] Suppression of tumorigenicity 2 protein Activates cardiac fibroblasts and induces collagen synthesis through neuropilin 1 [90] Tissue factor pathway inhibitor Inhibits tissue factor and coagulation factor VIIa complexes as well as prothrombinase [91] Transferrin receptor protein 1 Mediates transferrin binding and cellular iron uptake [92] Glial cell line--derived neurotrophic growth factor…”
Section: Diagnostic Developmentmentioning
confidence: 99%
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