“…One might reason that there is an evolutionary advantage to having an immune system that recognizes and responds to HSP60 in different ways from birth [44]. Because upregulation of HSP60 is a dependable sign of cell stress or hyperactivity, HSP60 might allow the body to sense disruptions in tissue homeostasis [78,79]. Indeed, increased HSP60 levels in the circulation have been linked to several Review Trends in Immunology February 2011, Vol.…”