Biomarkers and optical based biosensors in cardiac disease detection: early and accurate diagnosis

Nejati-Koshki, Kazem; Fathi, Farzaneh; Arabzadeh, AmirAhmad; Mohammadzadeh, Alireza

doi:10.1039/d3ay01414b

Cited by 12 publications

(2 citation statements)

References 144 publications

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“…The energy from the light particle is transferred to the molecules in the material and the remaining power is emitted in what is called inelastic light scattering . Raman spectroscopy works based on the inelastically scattered ray generated from the vibrational modes of molecular bonds upon laser excitation . Raman spectroscopy can deliver high molecular specificity, rapid implementation and low to moderate cost .…”

Section: Biosensorsmentioning

confidence: 99%

“… 168 Raman spectroscopy works based on the inelastically scattered ray generated from the vibrational modes of molecular bonds upon laser excitation. 169 Raman spectroscopy can deliver high molecular specificity, rapid implementation and low to moderate cost. 170 El-Said et al prepared indium tin oxide (Ag NPT/ITO) substrates modified with Ag nanopine tree film using electrochemical deposition of Ag from aqueous silver nitrate solution for the detection of myoglobin.…”

Section: Biosensorsmentioning

confidence: 99%

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Biosensing Platforms for Cardiac Biomarker Detection

Gerdan,

Saylan,

Denizli

2024

ACS Omega

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Myocardial infarction (MI) is a cardiovascular disease that occurs when there is an elevated demand for myocardial oxygen as a result of the rupture or erosion of atherosclerotic plaques. Globally, the mortality rates associated with MI are steadily on the rise. Traditional diagnostic biomarkers employed in clinical settings for MI diagnosis have various drawbacks, prompting researchers to investigate fast, precise, and highly sensitive biosensor platforms and technologies. Biosensors are analytical devices that combine biological elements with physicochemical transducers to detect and quantify specific compounds or analytes. These devices play a crucial role in various fields including healthcare, environmental monitoring, food safety, and biotechnology. Biosensors developed for the detection of cardiac biomarkers are typically electrochemical, mass, and optical biosensors. Nanomaterials have emerged as revolutionary components in the field of biosensing, offering unique properties that significantly enhance the sensitivity and specificity of the detection systems. This review provides a comprehensive overview of the advancements and applications of nanomaterial-based biosensing systems. Beginning with an exploration of the fundamental principles governing nanomaterials, we delve into their diverse properties, including but not limited to electrical, optical, magnetic, and thermal characteristics. The integration of these nanomaterials as transducers in biosensors has paved the way for unprecedented developments in analytical techniques. Moreover, the principles and types of biosensors and their applications in cardiovascular disease diagnosis are explained in detail. The current biosensors for cardiac biomarker detection are also discussed, with an elaboration of the pros and cons of existing platforms and concluding with future perspectives.

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Section: Biosensorsmentioning

confidence: 99%