Biomarkers and the prediction of adverse outcomes in patients with acute decompensated heart failure and kidney injury

Highlights. The article is a review of current literary data on the problem of acute decompensated heart failure. The review highlights the basic principles of the diagnosis and treatment, as well as the problems of their implementation into clinical practice.Abstract Acute decompensated heart failure (ADHF) is a life-threatening condition that requires an emergency hospitalization for intensive treatment. Moreover, it is the event that worsens the patient's further prognosis. Frequent rehospitalizations for decompensation of heart failure reduce life expectancy and quality, and are also a significant economic problem in practical health care. The increasing number of patients with heart failure leads to the growing number of patients seeking medical help for acute decompensated heart failure. More than half of the patients are re-hospitalized within a year for the same reason. The predicted increase in the prevalence of CHF worldwide makes the management of such patients a global medical and social problem. Patients delay, low compliance and insufficient ambulatory monitoring are the factors that need to be influenced in order to improve the prognosis. The article is a review of literary data on the epidemiology of ADHF, diagnosis, treatment and outpatient observation of patients with acute decompensated heart failure. The problems of compliance, the prospects for modern methods of remote monitoring and the possibilities of new drugs are discussed in the article.

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Chronic and acute decompensated heart failure: topical issues

Okunev¹,

Кочергина

Кашталап

2022

Kompleks. probl. serdečno-sosud. zabol.

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FAS system diagnostic and prognostic value in patients with chronic heart failure

Tokmachev,

Budnevsky,

Kravchenko

et al. 2024

Journal of Volgograd State Medical University

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The authors conducted the descriptive literature synthesis to present the structure and mechanism of the FAS family action, the purpose of determining the concentration of biomarkers in blood serum, the relationship of various FAS ligands levels with the patient’s clinical condition - the HF functional class (FC), as well as the sFASL using possibility to predict the HF course. The review analyzed 22 studies on the FAS system biomarkers participation in the HF pathogenesis and the relationship of their serum concentrations with the HF severity. A threshold sFASL value of 0.0999 ng/ml is associated with this pathology unfavorable course, while the increase in sFASL degree directly correlates with an increase in the FC of HF, the progression and death risks.

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Early diagnosis of acute kidney dysfunction in combined mechanical injury (literature review)

Ivanov,

Gaiduk,

Pershko

et al. 2024

Vrach

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The improvement of clinical and laboratory research methods contributes to the timely diagnosis and improvement of the effectiveness of disease therapy, which ensures the preservation of public health, reducing the time of temporary disability and rehabilitation of patients. The evidence base for determining the predictive role of biomarkers of renal dysfunction is small and is available only for a very limited number of substances – some serum proteins, the synthesis of which increases with acute kidney injury, low molecular weight urine proteins, intracellular enzymes of tubular epithelial cells and some other substances. This article provides an overview of modern laboratory methods of early diagnosis of kidney dysfunction in combined mechanical injury.

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Biomarkers and the prediction of adverse outcomes in patients with acute decompensated heart failure and kidney injury

Cited by 3 publications

References 22 publications

Chronic and acute decompensated heart failure: topical issues

Chronic and acute decompensated heart failure: topical issues

FAS system diagnostic and prognostic value in patients with chronic heart failure

Early diagnosis of acute kidney dysfunction in combined mechanical injury (literature review)

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