Biomarkers and Their Potential Use in Transplantation

Abstract

The article presents an overview of literature related to two topical issues in modern medicine: transplantation and biomarkers. There have been advances made in the use of immunoenzymometric and immunoadsorption assays in organ transplantation clinics for evaluating different situations. However, these methods fail to solve more complex and ambiguous transplantation problems: tolerance, personification of treatment, etc. In this regard, the first results of prospective studies using OMICS methods of genomics and proteinomics, in relation to the notion of transplantomics, are presented

Surfing the Big Data Wave: Omics Data Challenges in Transplantation

“…14 rejection, treatment outcomes, and immunosuppressive therapy adaptation. 19,20 Table 2 is a summary of omics studies published in the transplantation field with >70 reported articles. These studies focused on acute rejection (AR) with very little progress on chronic rejection/loss.…”

“…Monitoring biomarkers in transplantation aims to predict rejection, treatment outcomes, and immunosuppressive therapy adaptation. 19,20…”