Biomarkers as Independent Predictors of Bone Regeneration around Biomaterials: A Systematic Review of Literature

Albeshri, Sultan; Alblaihess, Abdulaziz; Niazy, Abdurahman A.; Ramalingam, Sundar; Sundar, Chalini; Alghamdi, Hamdan S.

doi:10.5005/jp-journals-10024-2306

Cited by 15 publications

(20 citation statements)

References 69 publications

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“…This is in accordance with our findings where intense staining of Collagen was seen in all the scaffolds 8 weeks post-implantation. Two studies have stated the expression of Collagen Type I was enhanced in bone ECM mineralization which is a valuable biomarker of bone remodeling/ mineralization starting approximately two weeks after implantation, only after the morphology transition of new bone to the native tissue occurred [50,51].…”

Section: Discussionmentioning

confidence: 99%

In vivo bone regeneration assessment of offset and gradient melt electrowritten (MEW) PCL scaffolds

et al. 2020

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Background Biomaterial-based bone tissue engineering represents a promising solution to overcome reduced residual bone volume. It has been previously demonstrated that gradient and offset architectures of three-dimensional melt electrowritten poly-caprolactone (PCL) scaffolds could successfully direct osteoblast cells differentiation toward an osteogenic lineage, resulting in mineralization. The aim of this study was therefore to evaluate the in vivo osteoconductive capacity of PCL scaffolds with these different architectures. Methods Five different calcium phosphate (CaP) coated melt electrowritten PCL pore sized scaffolds: 250 μm and 500 μm, 500 μm with 50% fibre offset (offset.50.50), tri layer gradient 250–500-750 μm (grad.250top) and 750–500-250 μm (grad.750top) were implanted into rodent critical-sized calvarial defects. Empty defects were used as a control. After 4 and 8 weeks of healing, the new bone was assessed by micro-computed tomography and immunohistochemistry. Results Significantly more newly formed bone was shown in the grad.250top scaffold 8 weeks post-implantation. Histological investigation also showed that soft tissue was replaced with newly formed bone and fully covered the grad.250top scaffold. While, the bone healing did not happen completely in the 250 μm, offset.50.50 scaffolds and blank calvaria defects following 8 weeks of implantation. Immunohistochemical analysis showed the expression of osteogenic markers was present in all scaffold groups at both time points. The mineralization marker Osteocalcin was detected with the highest intensity in the grad.250top and 500 μm scaffolds. Moreover, the expression of the endothelial markers showed that robust angiogenesis was involved in the repair process. Conclusions These results suggest that the gradient pore size structure provides superior conditions for bone regeneration.

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Section: Discussionmentioning

confidence: 99%

In vivo bone regeneration assessment of offset and gradient melt electrowritten (MEW) PCL scaffolds

et al. 2020

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“…TAcPh and BAcPH are seen as bone resorption marker whereas both TAlPh and BAlPh are assumed to play a role in osteoid formation and bone mineralization [33]. Therefore, these results indicate that the use of a membrane in osseous regeneration procedures of the jaws signi cantly enhances bone remodeling activity in the early healing phase and accelerates bone regeneration.…”

Section: Discussionmentioning

confidence: 84%

A Collagen Membrane Influences Bone Turnover Marker in Vivo After Bone Augmentation With Xenogenic Bone

Staedt

Dau

Schiegnitz

et al. 2020

Preprint

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Background:The aim was to compare early biochemical and histological osseous healing of chronic mandibular defects regenerated with bovine bone substitute with and without collagen membranein vivo. Methods:Eight weeks after formation of a lateral defect in the mandible of 40 rabbits, bovine bone substitute with (“+”;n=20) and without (“-“;n=20) collagen membrane was applied. Blood and bone was collected 24, 72 hours, 7, 14 and 21 days after surgery. Total acid phosphatase, bone acid phosphatase, total alkaline phosphatase and bone alkaline phosphatase activities were compared between groups. Formation of new bone was quantified histologically for all time points.Results:24 hours after surgery, bone alkaline phosphatase was significantly elevated in “+” group when compared to “-“ (p=0.012). After 72 hours, all bone turnover markers except for total acid phosphatase (p=0.078) where significantly elevated in “+” (all p<0.05). 14 days after surgery, the significant highest values for all bone turnover markers were detected in “-“ (all p<0.05). A significant difference in favor of group “-“ could also be detected after 3 weeks in terms of both acid phosphatases (p<0.05). In histology, no significant differences could be detected.Conclusion: Bone regeneration with bovine bone substitute material and collagen membrane shows a significantly earlier bone remodeling activity but does not seem to influence formation of new bone in histological samples.

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“…However, successful restorative treatment involving implants depends on interdisciplinary treatment planning, especially if pre-prosthetic orthodontic tooth alignment is required ( Richardson and Russell,2001 ). The roots of the teeth adjacent to the edentulous implant region must be parallel or slightly divergent to create sufficient bone ( Albeshri et al, 2018 ) for implant placement, and there must be sufficient space between the crowns to place and restore the implant( Rédua and Rédua,2018 ).…”

Section: Discussionmentioning

confidence: 99%

Successful treatment modalities for missing lateral incisors– A systematic review

Alqahtani

2021

The Saudi Dental Journal

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Background Effective management of Missing lateral incisor has remained a challenge for the clinicians. A multi-disciplinary approach involving orthodontist, restorative dental specialist, pediatric dental specialist, periodontist, oral surgeon and general dentist has proved ideal. Our aim is to review the ultimate esthetic success, and long term survival results between the orthodontic and restorative management of missing lateral incisor. Materials and methods Following the PRISMA guidelines, a systematic review of the published articles pertaining to the topic of interest was done. Searches were carried out in four different databases since February 2021 to April 2021. Results A total of 580 references were found from searches conducted in PubMed, Scopus, Cochrane and Web of Science, and 19 articles were selected and analyzed fully, after screening the title and abstract, 6 articles were included for the study. Conclusion An essential orthodontic space closure in combination with modern aesthetic prosthetic tooth replacement techniques has been reported to achieve greater success.

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Biomarkers as Independent Predictors of Bone Regeneration around Biomaterials: A Systematic Review of Literature

Abstract: Noninvasive and inexpensive methods of isolating and characterization of biomarkers from cellular and extracellular skeletal matrix during bone regeneration have proven value in evaluating success of bone biomaterials.

Cited by 15 publications

References 69 publications

In vivo bone regeneration assessment of offset and gradient melt electrowritten (MEW) PCL scaffolds

In vivo bone regeneration assessment of offset and gradient melt electrowritten (MEW) PCL scaffolds

A Collagen Membrane Influences Bone Turnover Marker in Vivo After Bone Augmentation With Xenogenic Bone

Successful treatment modalities for missing lateral incisors– A systematic review

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