Biomarkers as proxies for cognitive reserve: The role of high density lipoprotein cholesterol in first episode of psychosis

Herrero, Rebeca Magdaleno; García, Nancy Murillo; Ruiz, A.; Neergaard, Karl David; Crespo‐Facorro, Benedicto; Ayesa-Arriola, Rosa

doi:10.1016/j.rpsm.2023.03.002

Cited by 3 publications

(1 citation statement)

References 48 publications

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“…Previous research consistently shows that siblings tend to perform better than the proband in cognitive domains such as executive functions and memory [ 6 , 32 , 45 – 47 ]. Siblings had higher educational attainment and lower cannabis use rates ( Table 1 ), which may be protective factors that increase cognitive reserve against psychosis [ 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Studying the relationship between intelligence quotient and schizophrenia polygenic scores in a family design with first-episode psychosis population

Murillo-García,

Papiol,

Fernández-Cacho

et al. 2024

Eur. Psychiatr.

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Background. The intelligence quotient (IQ) of patients with first-episode psychosis (FEP) and their unaffected relatives may be related to the genetic burden of schizophrenia (SCZ). The polygenic score approach can be useful for testing this question. Aim. To assess the contribution of the polygenic risk scores for SCZ (PGS-SCZ) and polygenic scores for IQ (PGS-IQ) to the individual IQ and its difference from the mean IQ of the family (named family-IQ) through a family-based design in an FEP sample. Methods. The PAFIP-FAMILIES sample (Spain) consists of 122 FEP patients, 131 parents, 94 siblings, and 176 controls. They all completed the WAIS Vocabulary subtest for IQ estimation and provided a DNA sample. We calculated PGS-SCZ and PGS-IQ using the continuous shrinkage method. To account for relatedness in our sample, we performed linear mixed models. We controlled for covariates potentially related to IQ, including age, years of education, sex, and ancestry principal components. Results. FEP patients significantly deviated from their family-IQ. FEP patients had higher PGS-SCZ than other groups, whereas the relatives had intermediate scores between patients and controls. PGS-IQ did not differ between groups. PGS-SCZ significantly predicted the deviation from family-IQ, whereas PGS-IQ significantly predicted individual IQ. Conclusions. PGS-SCZ discriminated between different levels of genetic risk for the disorder and was specifically related to patients' lower IQ in relation to family-IQ. The genetic background of the disorder may affect neurocognition through complex pathological processes interacting with environmental factors that prevent the individual from reaching their familial cognitive potential.

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Section: Discussionmentioning

confidence: 99%

Studying the relationship between intelligence quotient and schizophrenia polygenic scores in a family design with first-episode psychosis population

Murillo-García,

Papiol,

Fernández-Cacho

et al. 2024

Eur. Psychiatr.

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Cognitive Reserve: “Whoever Had, Retained” …, and Much More

García-Portilla

2024

Spanish Journal of Psychiatry and Mental Health

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Interaction between catechol-O-methyltransferase Val/Met polymorphism and cognitive reserve for negative symptoms in schizophrenia

Hou,

Qin,

Hou

et al. 2024

World J Psychiatry

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BACKGROUND Cognitive reserve (CR) and the catechol-O-methyltransferase (COMT ) Val/Met polymorphism are reportedly linked to negative symptoms in schizophrenia. However, the regulatory effect of the COMT genotype on the relationship between CR and negative symptoms is still unexamined. AIM To investigate whether the relationship between CR and negative symptoms could be regulated by the COMT Val/Met polymorphism. METHODS In a cross-sectional study, 54 clinically stable patients with schizophrenia underwent assessments for the COMT genotype, CR, and negative symptoms. CR was estimated using scores in the information and similarities subtests of a short form of the Chinese version of the Wechsler Adult Intelligence Scale. RESULTS COMT Met-carriers exhibited fewer negative symptoms than Val homozygotes. In the total sample, significant negative correlations were found between negative symptoms and information, similarities. Associations between information, similarities and negative symptoms were observed in Val homozygotes only, with information and similarities showing interaction effects with the COMT genotype in relation to negative symptoms (information, β = -0.282, 95%CI: -0.552 to -0.011, P = 0.042; similarities, β = -0.250, 95%CI: -0.495 to -0.004, P = 0.046). CONCLUSION This study provides initial evidence that the association between negative symptoms and CR is under the regulation of the COMT genotype in schizophrenia.

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Biomarkers as proxies for cognitive reserve: The role of high density lipoprotein cholesterol in first episode of psychosis

Cited by 3 publications

References 48 publications

Studying the relationship between intelligence quotient and schizophrenia polygenic scores in a family design with first-episode psychosis population

Studying the relationship between intelligence quotient and schizophrenia polygenic scores in a family design with first-episode psychosis population

Cognitive Reserve: “Whoever Had, Retained” …, and Much More

Interaction between catechol-O-methyltransferase Val/Met polymorphism and cognitive reserve for negative symptoms in schizophrenia

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