Biomarkers for early stage of acute respiratory distress syndrome in septic patients: surfactant protein D and Clara cell protein

Surfactant Proteins A and D – New Diagnostic and Prognostic Biomarkers of Acute Respiratory Distress Syndrome in Septic Patients

“…Moreover, plasma SP-D is significantly higher in patients with the 2 nd stage of ARDS than in patients with the 1 st stage of ARDS (day 0 -154,6 ± 125,2 ng/ml vs. 451,8 ± 299,2 ng/ml; day 3 -129,3 ± 74,9 ng/ml vs. 362,9 ± 202,0 ng/ ml; day 5 -167,8 ± 120,4 ng/ml vs. 428,5 ± 372,4 ng/ml; day 7 -186,2 ± 127,1 ng/ml vs. 415,5 ± 337,0 ng/ml). Plasma SP-D on the day of sepsis diagnosis ≤ 253,0 ng/ml yields a sensitivity of 90,0% and specificity of 74,0% (AUC 0,83; 95% CI 0,631-0,951; p=0,0001) for the diagnosis of the 1 st stage of ARDS [6].…”

“…Clinical investigations at the V.A. Negovsky scientific research institute of general reanimatology in 2012-2013 have confirmed that plasma surfactant proteins A (SP-A) and D (SP-D) may be used as biomarkers of ARDS in septic patients with severe intraabdominal surgical infections [6].…”