Biomarkers for Kidney Injury in Cystic Fibrosis

Downes, Kevin J.; Goldstein, Stuart L.

doi:10.1007/978-94-007-7743-9_12-1

Cited by 1 publication

(3 citation statements)

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“…Other studies have also reported low urinary calcium excretion, with only 12% -20% of the patients having hypercalciuria (30,31). Bohles and Michalk found that urinary creatinine excretion was lower in CF patients than in controls (31). In the present study, despite a significant difference in the mean urinary calcium level between the healthy and patient groups, the difference in calcium excretion levels between the two groups was not significant.…”

Section: Discussioncontrasting

confidence: 70%

“…In the present study, hypocitraturia was observed in nearly 8% of children with CF, which was lower than the rate in other studies (8,19,28,31). In some studies, low citrate secretion has been reported in the urine of CF patients, and this low excretion appeared to be associated with hypokalemia and acidosis (28).…”

Section: Discussioncontrasting

confidence: 67%

“…In this study, hypocalciuria was observed in 77% of the patients. Other studies have also reported low urinary calcium excretion, with only 12% -20% of the patients having hypercalciuria (30,31). Bohles and Michalk found that urinary creatinine excretion was lower in CF patients than in controls (31).…”

Section: Discussionmentioning

confidence: 95%

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Comparative Study of Urinary Minerals and Their Effect on Stone Formation in Two Groups of Cystic Fibrosis (CF) and Healthy Children

et al. 2020

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Background: Cystic Fibrosis (CF) is a systemic autosomal disorder and the most important chronic lung disease in children. Oxalate is the end product of vitamin C metabolism, which increases the risk of kidney stones, urinary bladder stones, and calcium deposits in CF patients. Objectives: Considering the increased mineral excretion and the rate of stone formation in the urinary tract, examining the excretion of minerals will greatly help resolve clinical problems. Methods: This descriptive-analytical study was performed on CF and healthy children in Gorgan in 2018 - 19. In this study, 40 CF children and 40 healthy children were randomly selected. After obtaining informed consent from the parents of the children, a random urine sample was collected to evaluate urine minerals. Children with abnormal urinary mineral excretion underwent ultrasonography. The data were analyzed by SPSS 18 using descriptive indices (mean ± SD, frequency, and percentage) and statistical tests (independent t-test, chi-square test, and nonparametric tests). Results: Out of 80 CF and healthy children, 34 were girls, and the rest was boys. The mean age of the patients was 4.34 ± 3.38. The age difference was not significant between the groups (P > 0.05). The mean urinary levels of phosphorus, uric acid, magnesium, and citrate were 0.87 ± 1.01, 1.16 ± 0.68, 0.23 ± 0.18, 2.37 ± 3.13 mg/mg of creatinine. In the pediatric patient group, respectively (P < 0.001). The mean urinary calcium level in CF patients was 0.28 ± 0.39, which was lower than that in the healthy group. The mean urinary oxalate level was 0.13 ± 0.20 in CF patients, which was higher than that in the healthy group (P > 0.05). Hyperoxaluria, hyperuricosuria, hypomagnesiuria, and hypocitraturia occurred in 35, 30, 62, and 7.5% of the CF patients, respectively. Among the urinary minerals studied, hyperoxaluria was found to be a major determinant of stone formation risk in CF. No correlation was observed between the formation of stones and the rate of excretion of minerals (P > 0.05). Conclusions: In summary, CF patients are at an increased risk of developing citrate and calcium stones compared to the healthy group, which is associated with hyperuricosuria, hypocitraturia, and hyperoxaluria.

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Section: Discussioncontrasting

confidence: 70%